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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-MAR-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS08000 [old locus tag: SPH_1650 ]
  • pan locus tag?: PNEUPAN002866000
  • symbol: SPH_RS08000
  • pan gene symbol?: yfiC
  • synonym:
  • product: tRNA1(Val) (adenine(37)-N6)-methyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS08000 [old locus tag: SPH_1650 ]
  • symbol: SPH_RS08000
  • product: tRNA1(Val) (adenine(37)-N6)-methyltransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 1522686..1523435
  • length: 750
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (1522686..1523435) NCBI
  • BioCyc: SPH_RS08000 BioCyc
  • MicrobesOnline: see SPH_1650
  • PneumoBrowse for strain D39V: SPV_1365 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGGAAGAAGAACAATTATTAAAATCAGGAGAGCGCATTAACCAGCTCTTTTCGACAGAT
    ATCAAAATCATTCAAAATAGAGAGGTTTTTAGCTATTCGGTGGATAGTGTTCTCTTATCA
    CGATTTCCACGTTTTCCTAAGAAGGGGTTGATTGTGGATTTCTGTGCTGGGAATGGAGCA
    GTGGGGCTTTTTGCTAGCACTCGTACTCAAGCACAGATATTGTCTGTTGAGATTCAGGAG
    CGTTTGGCGGATATGGCTGAACGCTCTGTCCGTTTGAATGGATTAGAGGAGCAAATGCAG
    GTCATCTGCGATGATTTGAAAAATATGCCTGCTCACATTCAGGGGAGTAAGGTGGATATG
    ATTTTGTGTAATCCACCCTATTTCAAGGTGGATCCTTATTCTAATCTGAACGAGAGTGAA
    CATTATCTCTTGGCTCGACACGAAATCACGACTAATTTGGAAGAAATCTGTCGTAGTGCC
    CAGAGTATTCTCAAGTCTAATGGGCGTTTGGCCATGGTTCATCGTCCTGATCGACTTCTG
    GATATTTTGGATACGTTAAAACGACATAATCTAGCCCCTAAGCGCCTGCAGTTTGTTTAT
    CCAAAAAGAGAAAAGGAAGCCAATATGCTTTTGATTGAGGCGATCAAGGATGGCTCAACA
    AGTGGCTTTAAGGTCTTACCTCCTTTGATTGTCCACAATGATGATGGCTCTTATACGCCC
    GAAATCGAAGAGATTTATTATGGATCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    750

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS08000 [old locus tag: SPH_1650 ]
  • symbol: SPH_RS08000
  • description: tRNA1(Val) (adenine(37)-N6)-methyltransferase
  • length: 249
  • theoretical pI: 5.97582
  • theoretical MW: 28367.4
  • GRAVY: -0.325703

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein modification and repair protein-(glutamine-N5) methyltransferase, release factor-specific (TIGR03534; EC 2.1.1.-; HMM-score: 51.2)
    Genetic information processing Protein fate Protein modification and repair methyltransferase, HemK family (TIGR00536; HMM-score: 42.9)
    and 6 more
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific (TIGR03533; EC 2.1.1.-; HMM-score: 40.6)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD (TIGR00095; EC 2.1.1.171; HMM-score: 28.3)
    Unknown function Enzymes of unknown specificity putative methylase (TIGR00537; HMM-score: 26)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific (TIGR03704; EC 2.1.1.-; HMM-score: 23.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone/menaquinone biosynthesis methyltransferase (TIGR01934; EC 2.1.1.-; HMM-score: 17.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit (TIGR02469; EC 2.1.1.132; HMM-score: 12.8)
  • TheSEED: see SPH_1650
  • PFAM:
    NADP_Rossmann (CL0063) MTS; Methyltransferase small domain (PF05175; HMM-score: 52)
    and 16 more
    Cons_hypoth95; Conserved hypothetical protein 95 (PF03602; HMM-score: 37.5)
    Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 30.3)
    Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 28.3)
    UPF0020; Putative RNA methylase family UPF0020 (PF01170; HMM-score: 24.4)
    Methyltransf_15; RNA cap guanine-N2 methyltransferase (PF09445; HMM-score: 20.3)
    N6_Mtase; N-6 DNA Methylase (PF02384; HMM-score: 18.6)
    Methyltransf_11; Methyltransferase domain (PF08241; HMM-score: 18.6)
    Methyltr_RsmB-F; 16S rRNA methyltransferase RsmB/F (PF01189; HMM-score: 18.4)
    Met_10; Met-10+ like-protein (PF02475; HMM-score: 17)
    PrmA; Ribosomal protein L11 methyltransferase (PrmA) (PF06325; HMM-score: 15.7)
    no clan defined Plasmo_rep; Plasmodium repeat family (PF12135; HMM-score: 15.7)
    NADP_Rossmann (CL0063) Methyltransf_16; Lysine methyltransferase (PF10294; HMM-score: 14.5)
    Methyltransf_32; Methyltransferase domain (PF13679; HMM-score: 14)
    Methyltransf_24; Methyltransferase domain (PF13578; HMM-score: 13.5)
    BpsA_C; Branched-chain polyamine synthase A C-terminal domain (PF01861; HMM-score: 12.3)
    N6_N4_Mtase; DNA methylase (PF01555; HMM-score: 11.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.019423
    • TAT(Tat/SPI): 0.002429
    • LIPO(Sec/SPII): 0.000427
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MEEEQLLKSGERINQLFSTDIKIIQNREVFSYSVDSVLLSRFPRFPKKGLIVDFCAGNGAVGLFASTRTQAQILSVEIQERLADMAERSVRLNGLEEQMQVICDDLKNMPAHIQGSKVDMILCNPPYFKVDPYSNLNESEHYLLARHEITTNLEEICRSAQSILKSNGRLAMVHRPDRLLDILDTLKRHNLAPKRLQFVYPKREKEANMLLIEAIKDGSTSGFKVLPPLIVHNDDGSYTPEIEEIYYGS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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