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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS09300 [old locus tag: SPH_1907 ]
  • pan locus tag?: PNEUPAN003276000
  • symbol: SPH_RS09300
  • pan gene symbol?: cshA_2
  • synonym:
  • product: replication-associated recombination protein A

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS09300 [old locus tag: SPH_1907 ]
  • symbol: SPH_RS09300
  • product: replication-associated recombination protein A
  • replicon: chromosome
  • strand: +
  • coordinates: 1772697..1773968
  • length: 1272
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (1772697..1773968) NCBI
  • BioCyc: SPH_RS09300 BioCyc
  • MicrobesOnline: see SPH_1907
  • PneumoBrowse for strain D39V: SPV_1580 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGCCAGACAATCTCGCGCTTCGCATGCGCCCTAAAACCATCGACCAGGTCATCGGTCAG
    GAGCATCTGGTCGGACCTGGAAAAATCATCCGCCGCATGGTGGAAGCCAACCGCCTGTCC
    TCCATGATTCTATATGGCCCTCCGGGAATCGGCAAAACCAGTATTGCCTCTGCCATCGCT
    GGAACGACCAAATATGCCTTTCGAACTTTCAATGCGACAGTTGATAGTAAAAAGCGACTG
    CAAGAAATCTCGGAAGAAGCTAAATTTTCTGGTGGTCTCGTCCTATTGCTAGACGAAATT
    CATCGACTAGATAAGACCAAGCAAGACTTCCTCTTGCCTCTCTTGGAAAGTGGACTGGTC
    ATCATGATTGGAGCAACGACTGAAAATCCTTTCTTTTCCGTCACTCCTGCCATTCGTAGC
    CGTGTTCAAATTTTTGAGTTGGAACCTCTGTCTAACCAAGACGTCAAAGAGGCCCTGCAG
    ATAGCTCTAAGTAACCCTGAACGTGGTTTTAATTTTCCAATAGAACTAGATGAGGATGCG
    CTGGATTTCATCGCAACCTCTACAAACGGAGACCTTCGCTCTGCCTTTAACTCACTGGAC
    TTGGCTGTTCTCTCTACCCCTGAGAATGACGAGGGCATTCGCCACATCACCTTAGACATC
    ATGGAAAATAGTCTTCAGAGAAGCTACATCACTATGGACAAGGATGGAGACGGTCACTAT
    GATGTTCTATCTGCCCTGCAAAAGTCTATCCGTGGCTCAGATGTGGATGCCAGTCTCCAC
    TATGCTGCCCGCTTGATTGAGGCTGGGGATCTGCCTAGTCTCGCTCGTCGCTTGACTGTT
    ATCGCCTATGAAGATATCGGCTTAGCCAATCCTGAGGCCCAGATTCATACCGTGACTGCT
    CTGGATGCTGCCCAGAAGATTGGGTTCCCAGAAGCCCGCATTCTCATTGCCAATGTCGTG
    ATTGATTTGGCCCTTTCTCCAAAATCCAACTCAGCCTATGTAGCTATGGATAAGGCACTT
    GCTGACCTCAAAACATCAGGGCACTTGCCTATTCCGCGACACCTACGTGATGGGCACTAC
    AGTGGAAGCAAGGAACTGGGGAATGCCCAAGACTATCTCTATCCACACAACTATCCTGGA
    AATTGGGTCAAGCAAGACTATCTGCCAGAAAAAATTCGTAATCATCACTATTTCCAAGCA
    GAAGATACTGGTAAATATGAACGGGCTTTGGCTCAAAGAAAGGAAGCTATCGACCGTTTG
    CGAAAAATCTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1272

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS09300 [old locus tag: SPH_1907 ]
  • symbol: SPH_RS09300
  • description: replication-associated recombination protein A
  • length: 423
  • theoretical pI: 6.1049
  • theoretical MW: 46968.1
  • GRAVY: -0.279196

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 73.3)
    and 20 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair Holliday junction DNA helicase RuvB (TIGR00635; EC 3.6.4.12; HMM-score: 47.5)
    Cellular processes Cellular processes Sporulation and germination ATP-dependent protease LonB (TIGR02902; EC 3.4.21.-; HMM-score: 41.2)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent protease LonB (TIGR02902; EC 3.4.21.-; HMM-score: 41.2)
    Cellular processes Cellular processes Sporulation and germination ATP-dependent protease, Lon family (TIGR02903; EC 3.4.21.-; HMM-score: 37.4)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent protease, Lon family (TIGR02903; EC 3.4.21.-; HMM-score: 37.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DnaA regulatory inactivator Hda (TIGR03420; HMM-score: 31.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta' subunit (TIGR00678; EC 2.7.7.7; HMM-score: 26.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair orc1/cdc6 family replication initiation protein (TIGR02928; HMM-score: 21.9)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides putative ATP-dependent protease (TIGR00764; HMM-score: 21.8)
    AAA family ATPase, CDC48 subfamily (TIGR01243; HMM-score: 21.4)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides endopeptidase La (TIGR00763; EC 3.4.21.53; HMM-score: 21.2)
    Cellular processes Cellular processes Other gas vesicle protein GvpN (TIGR02640; HMM-score: 20)
    Cellular processes Cellular processes Cell division ATP-dependent metallopeptidase HflB (TIGR01241; EC 3.4.24.-; HMM-score: 19.4)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent metallopeptidase HflB (TIGR01241; EC 3.4.24.-; HMM-score: 19.4)
    26S proteasome subunit P45 family (TIGR01242; HMM-score: 19.4)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides ATP-dependent Clp protease ATP-binding subunit ClpA (TIGR02639; HMM-score: 18.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion AAA-ATPase EccA (TIGR03922; HMM-score: 16.3)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides proteasome ATPase (TIGR03689; EC 3.6.4.8; HMM-score: 16.2)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair chromosomal replication initiator protein DnaA (TIGR00362; HMM-score: 10.8)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent chaperone protein ClpB (TIGR03346; HMM-score: 10.8)
  • TheSEED: see SPH_1907
  • PFAM:
    post-AAA (CL0604) MgsA_C; MgsA AAA+ ATPase C terminal (PF12002; HMM-score: 204.3)
    and 23 more
    AAA_lid (CL0671) AAA_assoc_2; AAA C-terminal domain (PF16193; HMM-score: 86.3)
    P-loop_NTPase (CL0023) AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 53.5)
    RuvB_N; Holliday junction DNA helicase RuvB P-loop domain (PF05496; HMM-score: 49.2)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 29.2)
    AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 27)
    Sigma54_activat; Sigma-54 interaction domain (PF00158; HMM-score: 26.5)
    AAA_14; AAA domain (PF13173; HMM-score: 23.4)
    TIP49; TIP49 P-loop domain (PF06068; HMM-score: 20.7)
    Sigma54_activ_2; Sigma-54 interaction domain (PF14532; HMM-score: 20.6)
    AAA_22; AAA domain (PF13401; HMM-score: 17.4)
    Mg_chelatase; Magnesium chelatase, subunit ChlI (PF01078; HMM-score: 16.3)
    DNA_pol3_delta2; DNA polymerase III, delta subunit (PF13177; HMM-score: 16.1)
    IstB_IS21; IstB-like ATP binding protein (PF01695; HMM-score: 15.9)
    AAA_24; AAA domain (PF13479; HMM-score: 15)
    AAA_19; AAA domain (PF13245; HMM-score: 14.6)
    NB-ARC; NB-ARC domain (PF00931; HMM-score: 14.5)
    AAA_3; ATPase family associated with various cellular activities (AAA) (PF07726; HMM-score: 14)
    AAA_18; AAA domain (PF13238; HMM-score: 13.3)
    AAA_2; AAA domain (Cdc48 subfamily) (PF07724; HMM-score: 13.2)
    AAA_lid (CL0671) TIP49_C; TIP49 AAA-lid domain (PF17856; HMM-score: 12.4)
    P-loop_NTPase (CL0023) TniB; Bacterial TniB protein (PF05621; HMM-score: 12.2)
    ATPase_2; ATPase domain predominantly from Archaea (PF01637; HMM-score: 12)
    Parvo_NS1; Parvovirus non-structural protein NS1 (PF01057; HMM-score: 11.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9856
    • Cytoplasmic Membrane Score: 0.0015
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0129
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011946
    • TAT(Tat/SPI): 0.01839
    • LIPO(Sec/SPII): 0.001076
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MPDNLALRMRPKTIDQVIGQEHLVGPGKIIRRMVEANRLSSMILYGPPGIGKTSIASAIAGTTKYAFRTFNATVDSKKRLQEISEEAKFSGGLVLLLDEIHRLDKTKQDFLLPLLESGLVIMIGATTENPFFSVTPAIRSRVQIFELEPLSNQDVKEALQIALSNPERGFNFPIELDEDALDFIATSTNGDLRSAFNSLDLAVLSTPENDEGIRHITLDIMENSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVDASLHYAARLIEAGDLPSLARRLTVIAYEDIGLANPEAQIHTVTALDAAQKIGFPEARILIANVVIDLALSPKSNSAYVAMDKALADLKTSGHLPIPRHLRDGHYSGSKELGNAQDYLYPHNYPGNWVKQDYLPEKIRNHHYFQAEDTGKYERALAQRKEAIDRLRKI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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