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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS11410 [old locus tag: SPH_2328 ]
  • pan locus tag?: PNEUPAN003823000
  • symbol: pcpA
  • pan gene symbol?: cbpN
  • synonym:
  • product: choline-binding protein PcpA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS11410 [old locus tag: SPH_2328 ]
  • symbol: pcpA
  • product: choline-binding protein PcpA
  • replicon: chromosome
  • strand: -
  • coordinates: 2131738..2133663
  • length: 1926
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (2131738..2133663) NCBI
  • BioCyc: SPH_RS11410 BioCyc
  • MicrobesOnline: see SPH_2328
  • PneumoBrowse for strain D39V: SPV_1965 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    ATGAAAAAAACTACAATATTATCATTAACTACAGCTGCGGTTATTTTAGCAGCATATGTC
    CCTAATGAACCAATCCTAGCAGATACTCCTAGTTCGGAAGTAATCAAAGAGACTAAAGTT
    GGAAGTATTATTCAACAAAATAATATCAAATATAAGGTTCTAACTGTAGAAGGTAACATA
    GGAACTGTTCAAGTGGGTAATGGAGTTACTCCTGTAGAGTTTGAAGCTGGTCAAGATGGA
    AAACCATTCACGATTCCTACAAAAATCACAGTAGGTGATAAAGTATTTACCGTTACTGAA
    GTAGCTAGTCAAGCTTTTAGTTATTATCCAGATGAAACAGGTAGAATTGTCTACTATCCT
    AGCTCTATTACTATCCCATCAAGCATAAAAAAAATACAAAAAAAAGGCTTCCATGGAAGT
    AAAGCTAAAACTATTATTTTTGACAAAGGCAGTCAGCTGGAGAAAATTGAAGATAGAGCT
    TTTGATTTTTCTGAATTAGAAGAGATTGAATTGCCTGCATCTCTAGAATATATTGGAACA
    AGTGCATTTTCTTTTAGTCAAAAATTGAAAAAGCTAACCTTTTCCTCAAGTTCAAAATTA
    GAATTAATATCACATGAGGCTTTTGCTAATTTATCAAATTTAGAGAAACTAACATTACCA
    AAATCGGTTAAAACATTAGGAAGTAATCTATTTAGACTCACTACTAGCTTAAAACATGTT
    GATGTTGAAGAAGGAAATGAATCGTTTGCCTCAGTTGATGGTGTTTTGTTTTCAAAAGAT
    AAAACTCAATTAATTTATTATCCAAGTCAAAAAAATGACGAAAGTTATAAAACGCCTAAG
    GAGACAAAAGAACTTGCATCATATTCGTTTAATAAAAATTCTTACTTGAAAAAACTCGAA
    TTGAATGAAGGTTTAGAAAAAATCGGTACTTTTGCATTTGCGGATGCGATTAAACTTGAA
    GAAATTAGCTTACCAAATAGTTTAGAAACTATTGAACGTTTAGCCTTTTACGGTAATTTA
    GAATTAAAAGAACTTATATTACCAGATAATGTTAAAAATTTTGGTAAACACGTTATGAAC
    GGTTTACCAAAATTAAAAAGTTTAACAATTGGTAATAATATCAACTCATTGCCGTCCTTC
    TTCCTAAGTGGCGTCTTAGATTCATTAAAGGAAATTCATATTAAGAATAAAAGTACAGAG
    TTTTCTGTGAAAAAAGATACATTTGCAATTCCTGAAACTGTTAAGTTCTATGTAACATCA
    GAACATATAAAAGATGTTCTTAAATCAAATTTATCTACTAGTAATGATATCATTGTTGAA
    AAAGTAGATAATATAAAACAAGAAACTGATGTAGCTAAACCTAAAAAGAATTCTAATCAG
    GGAGTAGTTGGTTGGGTTAAAGACAAAGGTTTATGGTATTACTTAAACGAATCAGGTTCT
    ATGGCTACTGGTTGGGTTAAAGACAAAGGTTTATGGTATTACTTAAACGAATCAGGTTCC
    ATGGCTACTGGTTGGGTTAAAGACAAAGGCTTATGGTATTACTTAAATGAATCAGGTTCA
    ATGGCTACTGGTTGGGTTAAAGACAAAGGCTTATGGTATTACTTAAACGAATCAGGTTCA
    ATGGCTACTGGTTGGGTTAAAGACAAAGGCTTATGGTATTACTTAAATGAATCAGGTTCA
    ATGGCTACTGGTTGGGTTAAAGACAAAGGCTTATGGTATTACTTAAACGAATCAGGTTCA
    ATGGCTACTGGTTGGGTTAAAGACAAAGGCTTATGGTATTACTTAAATGAATCAGGTTCA
    ATGGCTACTGGTTGGTTTACAGTTTCTGGTAAATGGTACTATACCTATAATTCAGGAGAT
    TTATTAGTAAACACGACTACACCCGATGGCTATCGAGTCAATGCTAACGGTGAGTGGGTA
    GGATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1926

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS11410 [old locus tag: SPH_2328 ]
  • symbol: PcpA
  • description: choline-binding protein PcpA
  • length: 641
  • theoretical pI: 7.17969
  • theoretical MW: 71572.7
  • GRAVY: -0.348518

⊟Function[edit | edit source]

  • TIGRFAM:
    glucan-binding repeat (TIGR04035; HMM-score: 37.3)
  • TheSEED: see SPH_2328
  • PFAM:
    LRR (CL0022) LRR_5; BspA type Leucine rich repeat region (6 copies) (PF13306; HMM-score: 191.2)
    Choline_binding (CL0694) Choline_bind_1; Putative cell wall binding repeat (PF01473; HMM-score: 166.7)
    and 4 more
    Choline_bind_3; Choline-binding repeat (PF19127; HMM-score: 144.9)
    Choline_bind_2; Choline-binding repeat (PF19085; HMM-score: 53.4)
    LRR (CL0022) LRR_8; Leucine Rich Repeat (PF13855; HMM-score: 36.6)
    LRR_4; Leucine Rich repeats (2 copies) (PF12799; HMM-score: 14.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.18
    • Extracellular Score: 9.72
    • Internal Helices: 0
  • DeepLocPro: Extracellular
    • Cytoplasmic Score: 0.0002
    • Cytoplasmic Membrane Score: 0.0064
    • Cell wall & surface Score: 0.051
    • Extracellular Score: 0.9425
  • SignalP: Signal peptide SP(Sec/SPI) length 27 aa
    • SP(Sec/SPI): 0.97212
    • TAT(Tat/SPI): 0.003655
    • LIPO(Sec/SPII): 0.015784
    • Cleavage Site: CS pos: 27-28. ILA-DT. Pr: 0.9403
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKKTTILSLTTAAVILAAYVPNEPILADTPSSEVIKETKVGSIIQQNNIKYKVLTVEGNIGTVQVGNGVTPVEFEAGQDGKPFTIPTKITVGDKVFTVTEVASQAFSYYPDETGRIVYYPSSITIPSSIKKIQKKGFHGSKAKTIIFDKGSQLEKIEDRAFDFSELEEIELPASLEYIGTSAFSFSQKLKKLTFSSSSKLELISHEAFANLSNLEKLTLPKSVKTLGSNLFRLTTSLKHVDVEEGNESFASVDGVLFSKDKTQLIYYPSQKNDESYKTPKETKELASYSFNKNSYLKKLELNEGLEKIGTFAFADAIKLEEISLPNSLETIERLAFYGNLELKELILPDNVKNFGKHVMNGLPKLKSLTIGNNINSLPSFFLSGVLDSLKEIHIKNKSTEFSVKKDTFAIPETVKFYVTSEHIKDVLKSNLSTSNDIIVEKVDNIKQETDVAKPKKNSNQGVVGWVKDKGLWYYLNESGSMATGWVKDKGLWYYLNESGSMATGWVKDKGLWYYLNESGSMATGWVKDKGLWYYLNESGSMATGWVKDKGLWYYLNESGSMATGWVKDKGLWYYLNESGSMATGWVKDKGLWYYLNESGSMATGWFTVSGKWYYTYNSGDLLVNTTTPDGYRVNANGEWVG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Laura Selva, Pilar Ciruela, Krystle Blanchette, Eva del Amo, Roman Pallares, Carlos J Orihuela, Carmen Muñoz-Almagro
Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae.
PLoS One: 2012, 7(7);e41587
[PubMed:22848535] [WorldCat.org] [DOI] (I p)

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