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70585
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Hu15
serotype 19A
Hu17
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INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
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SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
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SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
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TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_0776 [new locus tag: SPJ_RS03865 ]
  • pan locus tag?: PNEUPAN001810000
  • symbol: coaA
  • pan gene symbol?: coaA
  • synonym:
  • product: pantothenate kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_0776 [new locus tag: SPJ_RS03865 ]
  • symbol: coaA
  • product: pantothenate kinase
  • replicon: chromosome
  • strand: -
  • coordinates: 743398..744318
  • length: 921
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGACCAACGAATTTTTACATTTTGAAAAAATCAGCCGCCAGACTTGGCAATCTTTACAT
    CGAAAGACAACACCTCCTTTGACAGAAGAAGAATTGGAATCTATCAAGAGTTTTAATGAC
    CAAATCAGTCTCCAAGACGTTACAGATATCTATCTCCCCTTGGCTCATCTGATTCAGATT
    TACAAGCGAACTAAGGAAGATTTAGCCTTTTCAAAAGGAATTTTCCTCCAACGTGAAAGT
    AAATCTCAACCTTTTATTATTGGGGTTTCTGGGAGTGTTGCCGTTGGAAAATCCACAACC
    AGTCGCCTACTTCAAATCCTACTGTCCCGTACGTTTACAGATGCTACGGTTGAGTTGGTT
    ACAACTGATGGTTTTCTCTATCCCAATCAAACCTTGATTGAGCAGGGGATTTTAAATCGT
    AAAGGATTTCCTGAAAGCTATGATATGGAAGCTCTTCTCAACTTCTTGGACCGCATCAAA
    AATGGACAAGATGTAGATATTCCTGTCTATTCTCATGAAGTTTACGACATCGTACCCGAA
    AAGAAACAAAGTGTCAAAGCTGCTGATTTTGTAATTGTTGAGGGAATTAATGTCTTTCAA
    AATCCACAAAACGATCGTCTCTATATCACTGACTTCTTTGACTTTTCCATCTATGTAGAT
    GCTGGAGTAGATGATATTGAAAGTTGGTATCTGGACCGTTTCTTGAAGATGCTGAGCCTA
    GCCCAAAACGACCCTGATAGCTACTATTATCGTTTTACTCAGATGCCGATTGGGGAAGTG
    GAGTCCTTTGCCCATCAGGTCTGGATCAGTATCAATCTCACAAATCTGCAAAATTATATT
    GAACCAACCAGAAATCGTGCAGAAGTGATTCTTCATAAAAGCAAGAACCATGAAATCGAT
    GAAATTTACTTAAAAAAGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    921

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_0776 [new locus tag: SPJ_RS03865 ]
  • symbol: CoaA
  • description: pantothenate kinase
  • length: 306
  • theoretical pI: 4.80329
  • theoretical MW: 35555
  • GRAVY: -0.338889

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.1.33?  ExPASy
    Pantothenate kinase ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A pantothenate kinase (TIGR00554; EC 2.7.1.33; HMM-score: 330.4)
    and 1 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 62.8)
  • TheSEED  :
    • Pantothenate kinase (EC 2.7.1.33)
    Cofactors, Vitamins, Prosthetic Groups, Pigments Coenzyme A Coenzyme A Biosynthesis  Pantothenate kinase (EC 2.7.1.33)
  • PFAM:
    P-loop_NTPase (CL0023) PRK; Phosphoribulokinase / Uridine kinase family (PF00485; HMM-score: 56.1)
    and 3 more
    no clan defined DnaB; DnaB-like helicase N terminal domain (PF00772; HMM-score: 13.3)
    ER; Enhancer of rudimentary (PF01133; HMM-score: 13.3)
    P-loop_NTPase (CL0023) CoaE; Dephospho-CoA kinase (PF01121; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001666
    • TAT(Tat/SPI): 0.000238
    • LIPO(Sec/SPII): 0.000398
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISLQDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSRLLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIKNGQDVDIPVYSHEVYDIVPEKKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIYVDAGVDDIESWYLDRFLKMLSLAQNDPDSYYYRFTQMPIGEVESFAHQVWISINLTNLQNYIEPTRNRAEVILHKSKNHEIDEIYLKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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