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serotype 4
D39
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D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
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ATCC 49619
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ATCC 700669
serotype 23F
BM6001
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BVJ1JL
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CGSP14
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G54
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HU-OH
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Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_2105 [new locus tag: SPJ_RS10445 ]
  • pan locus tag?: PNEUPAN003749000
  • symbol: SPJ_2105
  • pan gene symbol?: pstS1
  • synonym:
  • product: ABC transporter substrate-binding protein - phosphate transport

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_2105 [new locus tag: SPJ_RS10445 ]
  • symbol: SPJ_2105
  • product: ABC transporter substrate-binding protein - phosphate transport
  • replicon: chromosome
  • strand: +
  • coordinates: 1954973..1955848
  • length: 876
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGAAATTCAAAAAAATGCTTACTCTTGCAGCCATTGGCTTATCAGGATTTGGGCTTGTT
    GCCTGTGGCAATCAGTCAGCTGCTTCCAAACAGTCAGCTTCAGGAACGATTGAGGTGATT
    TCACGAGAAAATGGCTCTGGGACACGGGGTGCCTTCACAGAAATCACAGGGATTCTCAAA
    AAAGACGGTGATAAAAAAATTGACAACACTGCCAAAACAGCTGTGATTCAAAATAGTACA
    GAAGGTGTTCTCTCAGCAGTTCAAGGGAATGCTAATGCTATCGGCTACATCTCCTTGGGA
    TCTTTAACGAAATCTGTCAAGGCTTTAGAGATTGATGGTGTCAAGGCTAGTCGAGACACA
    GTTTTAGATGGTGAATACCCTCTTCAACGTCCCTTCAACATTGTTTGGTCTTCTAATCTT
    TCCAAGCTAGGTCAAGATTTTATCAGCTTTATCCACTCCAAACAAGGTCAACAAGTGGTC
    ACAGATAATAAATTTATTGAAGCTAAAACCGAAACCACGGAATATACAAGCCAACACTTA
    TCAGGCAAGTTGTCTGTTGTAGGTTCCACTTCAGTATCTTCTTTAATGGAAAAATTAGCA
    GAAGCTTATAAAAAAGAAAATCCAGAAGTTACGATTGATATTACCTCTAATGGGTCTTCA
    GCAGGTATTACCGCTGTTAAGGAGAAAACCGCTGATATTGGTATGGTTTCTAGGGAATTA
    ACTCCTGAAGAAGGTAAGAGTCTCACCCATGATGCTATTGCTTTAGACGGTATTGCTGTT
    GTGGTCAATAATGACAATAAGGCAAGCCAAGTCAGTATGGCTGAACTTGCAGACGTTTTT
    AGTGGCAAATTAACCACCTGGGACAAGATTAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    876

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_2105 [new locus tag: SPJ_RS10445 ]
  • symbol: SPJ_2105
  • description: ABC transporter substrate-binding protein - phosphate transport
  • length: 291
  • theoretical pI: 6.80974
  • theoretical MW: 30756.5
  • GRAVY: -0.191409

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Anions phosphate binding protein (TIGR02136; HMM-score: 181.2)
    and 4 more
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, phosphate-binding protein PstS (TIGR00975; HMM-score: 61.9)
    phosphate ABC transporter substrate-binding protein (TIGR04505; HMM-score: 60.8)
    Signal transduction Regulatory functions DNA interactions aminoethylphosphonate catabolism associated LysR family transcriptional regulator (TIGR03339; HMM-score: 23.5)
    tungstate ABC transporter binding protein WtpA (TIGR03730; HMM-score: 14)
  • TheSEED  :
    • Phosphate ABC transporter, substrate-binding protein PstS
    Phosphorus Metabolism Phosphorus Metabolism - no subcategory High affinity phosphate transporter and control of PHO regulon  Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1)
    and 1 more
    Phosphorus Metabolism Phosphorus Metabolism - no subcategory Phosphate metabolism  Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1)
  • PFAM:
    PBP (CL0177) PBP_like_2; PBP superfamily domain (PF12849; HMM-score: 115.1)
    and 5 more
    PBP_like; PBP superfamily domain (PF12727; HMM-score: 52.9)
    SBP_bac_11; Bacterial extracellular solute-binding protein (PF13531; HMM-score: 31.1)
    LysR_substrate; LysR substrate binding domain (PF03466; HMM-score: 29.6)
    SBP_bac_1; Bacterial extracellular solute-binding protein (PF01547; HMM-score: 19.9)
    no clan defined DUF2877; Protein of unknown function (DUF2877) (PF11392; HMM-score: 13.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0006
    • Cytoplasmic Membrane Score: 0.8245
    • Cell wall & surface Score: 0.0232
    • Extracellular Score: 0.1517
  • SignalP: Signal peptide LIPO(Sec/SPII) length 21 aa
    • SP(Sec/SPI): 0.010338
    • TAT(Tat/SPI): 0.000228
    • LIPO(Sec/SPII): 0.989107
    • Cleavage Site: CS pos: 21-22. LVA-CG. Pr: 0.9895
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKFKKMLTLAAIGLSGFGLVACGNQSAASKQSASGTIEVISRENGSGTRGAFTEITGILKKDGDKKIDNTAKTAVIQNSTEGVLSAVQGNANAIGYISLGSLTKSVKALEIDGVKASRDTVLDGEYPLQRPFNIVWSSNLSKLGQDFISFIHSKQGQQVVTDNKFIEAKTETTEYTSQHLSGKLSVVGSTSVSSLMEKLAEAYKKENPEVTIDITSNGSSAGITAVKEKTADIGMVSRELTPEEGKSLTHDAIALDGIAVVVNNDNKASQVSMAELADVFSGKLTTWDKIK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

C J Orihuela, J Mills, C W Robb, C J Wilson, D A Watson, D W Niesel
Streptococcus pneumoniae PstS production is phosphate responsive and enhanced during growth in the murine peritoneal cavity.
Infect Immun: 2001, 69(12);7565-71
[PubMed:11705934] [WorldCat.org] [DOI] (P p)

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