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serotype 4
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D39V
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EF3030
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670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
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A66
serotype 3
AP200
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ASP0581
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ATCC 49619
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ATCC 700669
serotype 23F
BM6001
serotype 19F
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serotype 14
G54
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HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_2204 [new locus tag: SPJ_RS10915 ]
  • pan locus tag?: PNEUPAN003872000
  • symbol: dltA
  • pan gene symbol?: dltA
  • synonym:
  • product: D-alanine-activating enzyme

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_2204 [new locus tag: SPJ_RS10915 ]
  • symbol: dltA
  • product: D-alanine-activating enzyme
  • replicon: chromosome
  • strand: -
  • coordinates: 2054653..2056203
  • length: 1551
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    GTGTCAAATAAACCAATAGCAGATATGATTGAAACCATTGAGCATTTTGCTCAGACACAG
    CCTAGCTATCCTGTCTATAATGTTTTGGGGCAGGAACACACTTATGGCGATTTAAAGGCT
    GATTCGGATAGTTTGGCTGCAGTCATTGACCAACTAGGCTTGCCTGAGAAGTCTCCTGTG
    GTTGTTTTTGGTGGCCAAGAATATGAAATGTTGGCAACCTTTGTAGCGCTGACTAAGTCA
    GGTCATGCCTACATTCCAATTGATAGCCATTCGGCCTTGGAGCGAGTTTCAGCTATTTTA
    GAAGTAGCAGAGCCAAGCTTGATTATTGCCATTTCAGCCTTTCCCTTGGAGCAGGTTTCT
    ACACCAATGATAAATCTAGCTCAGGTTCAAGAAGCCTTTGCCCAAGGGAATAACTATGAA
    ATCACGCATCCAGTCAAGGGAGATGATAATTACTACATTATCTTTACTTCTGGTACGACT
    GGTAAGCCTAAGGGAGTGCAGATTTCACATGATAATCTCCTCAGCTTTACAAACTGGATG
    ATTACGGATAAGGAATTTGCGACACCGAGTCGTCCGCAAATGCTGGCACAGCCACCTTAT
    TCTTTTGACTTGTCTGTCATGTATTGGGCACCGACCTTGGCACTTGGTGGTACGCTTTTC
    ACTCTTCCTTCAGTCATCACTCAGGACTTTAAGCAACTCTTTGCGGCTATCTTTTCATTG
    CCAATCGCTATCTGGACATCAACACCATCCTTTGCAGATATGGCCATGTTGTCTGAATAC
    TTCAACAGTGAGAAAATGCCTGGAATCACTCATTTCTACTTTGATGGTGAAGAATTGACG
    GTCAAAACAGCTCAAAAACTGCGCGAGCGTTTCCCAAATGCCCATATCATCAATGCTTAC
    GGCCCAACAGAAGCGACAGTAGCTCTGTCAGCAGTTGCCGTGACAGACGAGATGTTAGCG
    ACTCTCAAACGCCTACCAATCGGCTATACCAAGGCTGATTCTCCAACCTTTATCATTGAC
    GAGGAAGGAAATAAACTGCCAAATGGTGAGCAGGGAGAAATCATTGTTTCTGGGCCAGCT
    GTTTCAAAAGGTTATATGAACAATCCTGAAAAAACAGCAGAAGCCTTCTTTGAGTTTGAA
    AATCTGCCAGCCTATCACACAGGCGATGTGGGAACCATGACAGATGAGGGCTTGCTTCTC
    TACGGCGGACGCATGGACTTCCAGATTAAGTTCAACGGTTACCGCATTGAGTTAGAAGAT
    GTCTCTCAAAACCTCAACAAGTCTCGCTTTATCGAATCTGCTGTCGCAGTACCGCGCTAT
    AACAAGGACCACAAGGTACAAAATCTATTGGCTTATGTCATCTTAAAAGACGGTGTTCGT
    GAGCAGTTTGAGCGAGATATCGATATTACCAAGGCCATCAAGGAAGACCTGACAGACATC
    ATGATGTCCTACATGATGCCATCTAAATTCCTTTACCGAGACAGTTTGCCACTAACTCCA
    AATGGAAAGATTGACATCAAAGGATTGATTAACGAGGTGAATAAGAGATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1551

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_2204 [new locus tag: SPJ_RS10915 ]
  • symbol: DltA
  • description: D-alanine-activating enzyme
  • length: 516
  • theoretical pI: 4.57775
  • theoretical MW: 57407
  • GRAVY: -0.150969

⊟Function[edit | edit source]

  • reaction:
    EC 6.1.1.13?  ExPASy
    D-alanine--poly(phosphoribitol) ligase ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan D-alanine--poly(phosphoribitol) ligase, subunit 1 (TIGR01734; EC 6.1.1.13; HMM-score: 812.7)
    and 12 more
    amino acid adenylation domain (TIGR01733; HMM-score: 350.1)
    acyl-CoA ligase (AMP-forming), exosortase A-associated (TIGR03098; HMM-score: 163.1)
    L-aminoadipate-semialdehyde dehydrogenase (TIGR03443; EC 1.2.1.31; HMM-score: 98.1)
    Metabolism Transport and binding proteins Cations and iron carrying compounds (2,3-dihydroxybenzoyl)adenylate synthase (TIGR02275; EC 2.7.7.58; HMM-score: 90.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone O-succinylbenzoate-CoA ligase (TIGR01923; EC 6.2.1.26; HMM-score: 87.5)
    benzoate-CoA ligase family (TIGR02262; HMM-score: 86)
    acetate--CoA ligase (TIGR02188; EC 6.2.1.1; HMM-score: 80.9)
    dicarboxylate--CoA ligase PimA (TIGR03205; EC 6.2.1.23; HMM-score: 65.9)
    cyclohexanecarboxylate-CoA ligase (TIGR03208; EC 6.2.1.-; HMM-score: 62)
    propionate--CoA ligase (TIGR02316; EC 6.2.1.17; HMM-score: 47.5)
    Metabolism Central intermediary metabolism Other acetoacetate-CoA ligase (TIGR01217; EC 6.2.1.16; HMM-score: 40.6)
    4-coumarate--CoA ligase (TIGR02372; EC 6.2.1.12; HMM-score: 10.5)
  • TheSEED  :
    • D-alanine--poly(phosphoribitol) ligase subunit 1 (EC 6.1.1.13)
    Cell Wall and Capsule Gram-Positive cell wall components D-Alanyl Lipoteichoic Acid Biosynthesis  D-alanine--poly(phosphoribitol) ligase subunit 1 (EC 6.1.1.13)
    and 2 more
    Cell Wall and Capsule Gram-Positive cell wall components Teichoic and lipoteichoic acids biosynthesis  D-alanine--poly(phosphoribitol) ligase subunit 1 (EC 6.1.1.13)
    Virulence, Disease and Defense Virulence, Disease and Defense - no subcategory Streptococcus pyogenes Virulome  D-alanine--poly(phosphoribitol) ligase subunit 1 (EC 6.1.1.13)
  • PFAM:
    ANL (CL0378) AMP-binding; AMP-binding enzyme (PF00501; HMM-score: 264.3)
    and 2 more
    AMP-binding_C (CL0531) AMP-binding_C; AMP-binding enzyme C-terminal domain (PF13193; HMM-score: 31.8)
    Phage_tail_2 (CL0691) DUF5072; Domain of unknown function (DUF5072) (PF16807; HMM-score: 12.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008823
    • TAT(Tat/SPI): 0.000546
    • LIPO(Sec/SPII): 0.000818
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTTGKPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSLPIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNAHIINAYGPTEATVALSAVAVTDEMLATLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMNNPEKTAEAFFEFENLPAYHTGDVGTMTDEGLLLYGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDIMMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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