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serotype 1

NCBI: 05-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_RS01505 [old locus tag: SPJ_0299 ]
  • pan locus tag?: PNEUPAN001029000
  • symbol: SPJ_RS01505
  • pan gene symbol?: sulB
  • synonym: folC
  • product: bifunctional folylpolyglutamate synthase/dihydrofolate synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_RS01505 [old locus tag: SPJ_0299 ]
  • symbol: SPJ_RS01505
  • product: bifunctional folylpolyglutamate synthase/dihydrofolate synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 274477..275799
  • length: 1323
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAAAGAAATTGAAAATAATCAGTGGATTGCTAACTACCGGACGGACCAACCGCATTTT
    GGCTTGGAACGCATGGTGGAACTGTTAGCTTTGCGTGGCAATCCCCATCTCAAACTCAAG
    GTTATCCATATCGGAGGAACCAATGGCAAGGGTTCGACCATTGCTTTTTTGAAAAAGATG
    CTAGAAAAGCTAGGGCTGAGAGTTGGCGTGTTTAGCTCGCCCTATCTCATTCATTACACA
    GACCAGATTAGCATCAATGGGGAATCGATCTCAGAAGTGAGGCTAGAAGCTCTCATGGCA
    GACTATCAGTCTTTGCTGGAGGGAGAAGCGGTCGCCAATTTACAGGGCACAACCGAGTTT
    GAGATTATCACAGCCCTAGCCTATGACTACTTTGCCTCAGAGCAAGTAGATGTGGCTATC
    ATGGAAGTTGGCATGGGTGGACTTTTGGATAGTACCAATGTCTGTCAGCCCATTTTGACA
    GGAATTACAACTATTGGCTTGGATCATGTGGCCCTACTTGGTGACACCTTGGAGGCCATA
    GCAGAGCAGAAGGCAGGTATTATCAAACAAGGGATGCCCTTGGTAACAGGGCGTATTGCT
    CCAGAAGCCTTGGCTGTGATTGACCGCATTGCGGAAGGGAAAGATGCGCCGAGACTTGCC
    TACGGGACAGATTATCAGGTTCGTCATCAAGAAAGTGTGGTGACAGGGGAAGTCTTTGAC
    TATACAAGTGCTGTCAGACAAGGTCGCTTCCAGACTAGCCTGCTTGGTTTGTACCAAATA
    GAGAATGCTGGGATGGCCATAGCTTTACTTGATACTTTTTGTCAAGAAGATGGTCGAGAG
    CTAGCAAGCAATGATTTTCTTGGTCAAGCCTTGGAAGAAACAAGTTGGCCAGGGCGTTTG
    GAAATCGTGTCAAGAGATCCCTTGATGATTTTGGATGGAGCCCACAATCCCCATGCTATC
    AAGGCCTTGTTGGTAACCTTGCAAGAACGTTTTGCGGATTATCATAAGGAAATCCTCTTC
    ACTTGTATCAAAACCAAGGCCTTGGGGGATATGTTGGACTTGCTGGGAGCCATGCCAGAT
    ACCGAGCTTACTCTAACACATTTTGCGGATAGTCGGGCGACGGATGAAAACGTGCTGAAA
    GAGGCAGCTAAGTCTAGAAATCTCAGCTACCAAGATTGGCATGATTTTCTAGAGCAGAAT
    TTGACAGATAAAAAAGAAGAGAAACAAACAGTTAGGATTGTCACAGGTTCCTTGTATTTC
    TTGAGCCAAGTGAGGGCCTATCTGATGGAGAGGAAGAACGAGAATGGATACACAAAAGAT
    TGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1323

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_RS01505 [old locus tag: SPJ_0299 ]
  • symbol: SPJ_RS01505
  • description: bifunctional folylpolyglutamate synthase/dihydrofolate synthase
  • length: 440
  • theoretical pI: 4.69166
  • theoretical MW: 48932.4
  • GRAVY: -0.1575

⊟Function[edit | edit source]

  • reaction:
    EC 6.3.2.-?  ExPASy
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Folic acid bifunctional protein FolC (TIGR01499; EC 6.3.2.-; HMM-score: 385.7)
    and 7 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramyl-tripeptide synthetase (TIGR01085; HMM-score: 64.7)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (TIGR01143; EC 6.3.2.10; HMM-score: 36.1)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramate--L-alanine ligase (TIGR01082; EC 6.3.2.8; HMM-score: 31.9)
    Cellular processes Cellular processes Biosynthesis of natural products cyanophycin synthetase (TIGR02068; EC 6.3.2.29,6.3.2.30; HMM-score: 24.1)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramoylalanine--D-glutamate ligase (TIGR01087; EC 6.3.2.9; HMM-score: 21.1)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (TIGR01081; HMM-score: 15.7)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides tetraacyldisaccharide 4'-kinase (TIGR00682; EC 2.7.1.130; HMM-score: 12.7)
  • TheSEED: see SPJ_0299
  • PFAM:
    P-loop_NTPase (CL0023) Mur_ligase_M; Mur ligase middle domain (PF08245; HMM-score: 49.6)
    no clan defined Mur_ligase_C; Mur ligase family, glutamate ligase domain (PF02875; HMM-score: 42.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9998
    • Cytoplasmic Membrane Score: 0.0001
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0001
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00989
    • TAT(Tat/SPI): 0.000207
    • LIPO(Sec/SPII): 0.000367
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKEIENNQWIANYRTDQPHFGLERMVELLALRGNPHLKLKVIHIGGTNGKGSTIAFLKKMLEKLGLRVGVFSSPYLIHYTDQISINGESISEVRLEALMADYQSLLEGEAVANLQGTTEFEIITALAYDYFASEQVDVAIMEVGMGGLLDSTNVCQPILTGITTIGLDHVALLGDTLEAIAEQKAGIIKQGMPLVTGRIAPEALAVIDRIAEGKDAPRLAYGTDYQVRHQESVVTGEVFDYTSAVRQGRFQTSLLGLYQIENAGMAIALLDTFCQEDGRELASNDFLGQALEETSWPGRLEIVSRDPLMILDGAHNPHAIKALLVTLQERFADYHKEILFTCIKTKALGDMLDLLGAMPDTELTLTHFADSRATDENVLKEAAKSRNLSYQDWHDFLEQNLTDKKEEKQTVRIVTGSLYFLSQVRAYLMERKNENGYTKD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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