PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 20-APR-2021

⊟Summary

• organism: Streptococcus pneumoniae JJA
• locus tag: SPJ_RS01865 [old locus tag: SPJ_0369 ]
• pan locus tag^?: PNEUPAN001247000
• symbol: mvaD
• pan gene symbol^?: mvaD
• synonym:
• product: diphosphomevalonate decarboxylase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPJ_RS01865 [old locus tag: SPJ_0369 ]
• symbol: mvaD
• product: diphosphomevalonate decarboxylase
• replicon: chromosome
• strand: +
• coordinates: 355934..356887
• length: 954
• essential: unknown other strains

⊟Accession numbers

• Location: NC_012466 (355934..356887) NCBI
• BioCyc: SPJ_RS01865 BioCyc
• MicrobesOnline: see SPJ_0369
• PneumoBrowse for strain D39V: SPV_0347 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
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  481
  541
  601
  661
  721
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  841
  901
  
  ATGGATAGAGAGCCTGTAACAGTACGTTCCTACGCAAATATTGCTATTATCAAATATTGG
  GGAAAGAAAAAAGAAAAAGAGATGGTGCCTGCTACTAGCAGTATTTCTCTAACTTTGGAA
  AATATGTATACAGAGACGACCTTGTCGCCTTTACCAGCCAATGTAACAGCTGACGAATTT
  TACATCAATGGTCAGCTACAAAATGAGGTCGAGCATGCCAAGATGAGTAAGATTATTGAC
  CGTTATCGTCCAGCTGGTGAGGGCTTTGTCCGTATCGATACTCAAAACAATATGCCTACG
  GCAGCGGGCCTGTCCTCAAGTTCTAGTGGTTTGTCCGCCCTGGTCAAGGCTTGTAATGCT
  TATTTCAAGCTTGGATTGGATAGAAGTCAGTTGGCACAGGAAGCCAAATTTGCCTCAGGC
  TCTTCTTCTCGGAGTTTTTATGGACCACTAGGAGCCTGGGATAAGGATAGTGGAGAAATT
  TACCCTGTAGAGACAGACTTGAAACTAGCTATGATTATGTTGGTGCTAGAGGACAAGAAA
  AAACCAATCTCTAGCCGTGACGGGATGAAACTTTGTGTGGAAACCTCGACGACTTTCGAC
  GACTGGGTTCGTCAGTCTGAGAAGGACTATCAGGATATGCTGATTTATCTCAAGGAAAAT
  GATTTTGCCAAGATTGGAGAATTAACGGAGAAAAATGCCCTGGCTATGCATGCTACGACA
  AAGACTGCTAGTCCAGCCTTTTCTTATCTGACGGATGCCTCTTATGAGGCTATGGACTTT
  GTTCGCCAGCTTCGTGAGAAAGGAGAGGCCTGCTACTTTACCATGGATGCTGGTCCCAAT
  GTTAAGGTCTTCTGTCAGGAGAAAGACTTGGAGTATTTGTCAGAAATTTTCGGTCAGCGT
  TATCGCTTGATTGTGTCAAAAACAAAGGATTTGAGTCAAGATGATTGCTGTTAA
  60
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  954
  

⊟Protein

⊟General

• locus tag: SPJ_RS01865 [old locus tag: SPJ_0369 ]
• symbol: MvaD
• description: diphosphomevalonate decarboxylase
• length: 317
• theoretical pI: 4.92617
• theoretical MW: 35603.2
• GRAVY: -0.424606

⊟Function

• reaction:
  EC 4.1.1.33?  ExPASy
  Diphosphomevalonate decarboxylase ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO₂
• TIGRFAM:
  Metabolism Central intermediary metabolism Other diphosphomevalonate decarboxylase (TIGR01240; EC 4.1.1.33; HMM-score: 418.7)
  and 6 more
  Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate kinase (TIGR01920; EC 2.7.1.71; HMM-score: 21.6)
  Metabolism Central intermediary metabolism Other mevalonate kinase (TIGR00549; EC 2.7.1.36; HMM-score: 20.3)
  Metabolism Amino acid biosynthesis Aspartate family homoserine kinase (TIGR00191; EC 2.7.1.39; HMM-score: 18.1)
  Metabolism Energy metabolism Sugars galactokinase (TIGR00131; EC 2.7.1.6; HMM-score: 17.1)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (TIGR00154; EC 2.7.1.148; HMM-score: 14.6)
  Unknown function Enzymes of unknown specificity secondary thiamine-phosphate synthase enzyme (TIGR00149; HMM-score: 12.2)
• TheSEED: see SPJ_0369
• PFAM:
  GHMP_C (CL0677) MDD_C; Mevalonate 5-diphosphate decarboxylase C-terminal domain (PF18376; HMM-score: 76.9)
  and 2 more
  S5 (CL0329) GHMP_kinases_N; GHMP kinases N terminal domain (PF00288; HMM-score: 35)
  RRM (CL0221) RRM_5; RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (PF13893; HMM-score: 13.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.015776
  • TAT(Tat/SPI): 0.001448
  • LIPO(Sec/SPII): 0.001588
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000373459 NCBI
• UniProt: see SPJ_0369

⊟Protein sequence

• MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEYLSEIFGQRYRLIVSKTKDLSQDDCC

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: mvk > mvaD > SPJ_RS01870 > fni > SPJ_RS01880 > SPJ_RS01885 > SPJ_RS01890

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0347 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications