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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_RS02345 [old locus tag: SPJ_0464 ]
  • pan locus tag?: PNEUPAN001359000
  • symbol: SPJ_RS02345
  • pan gene symbol?: pyrG
  • synonym:
  • product: CTP synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_RS02345 [old locus tag: SPJ_0464 ]
  • symbol: SPJ_RS02345
  • product: CTP synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 441580..443187
  • length: 1608
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    ATGTCTACGAAATATATTTTTGTAACTGGTGGTGTGGTATCGTCTATTGGGAAAGGGATT
    GTGGCAGCGAGTCTAGGCCGTCTCTTGAAAAATCGTGGTCTCAAAGTAACCATTCAAAAG
    TTTGACCCTTATATCAATATTGATCCGGGAACCATGAGTCCTTACCAGCACGGGGAAGTT
    TTTGTGACAGATGACGGAGCTGAGACAGATTTGGACTTGGGTCACTATGAACGTTTTATC
    GATATCAATCTCAACAAATATTCCAACGTGACAACTGGGAAAATTTACAGTGAAGTTCTT
    CGTAAAGAACGCCGTGGAGAATACCTTGGGGCAACTGTTCAAGTCATTCCTCATATCACA
    GATGCTTTGAAAGAAAAAATCAAGCGTGCCGCTCTAACGACCGACTCTGATGTCATTATC
    ACAGAGGTTGGTGGAACAGTAGGAGATATCGAGTCCTTGCCATTCCTAGAGGCTCTTCGT
    CAGATGAAGGCAGATGTGGGTGCGGATAATGTCATGTATATCCATACAACCTTGCTTCCT
    TACCTCAAGGCTGCTGGTGAAATGAAAACCAAACCAACCCAACACTCTGTCAAAGAATTG
    CGTGGCTTGGGAATCCAACCAAATATGTTGGTTATTCGTACAGAAGAGCCAGCTGGTCAA
    GGAATTAAAAATAAACTGGCCCAGTTCTGTGATGTGGCACCAGAAGCCGTTATCGAATCG
    TTGGATGTTGAACACCTTTACCAAATTCCACTGAACTTGCAGGCACAAGGGATGGACCAA
    ATTGTTTGTGATCATTTGAAATTAGACGCACCAGCAGCGGCTATGACAGAATGGTCAGCC
    ATGGTGGACAAGGTCATGAACCTCAAGAAACAAGTTAAGATTTCCCTTGTTGGTAAGTAT
    GTGGAGTTGCAAGATGCCTATATCTCAGTGGTCGAAGCCTTGAAACACTCTGGCTATGTC
    AATGATACAGAAGTTAAAATCAATTGGGTCAATGCCAATGATGTGACAGCAGAGAATGTA
    GCAGAACTCTTGTCTGATGCGGACGGGATCATCGTACCAGGTGGTTTTGGTCAACGTGGT
    ACAGAAGGGAAAATCCAAGCCATCCGCTATGCGCGTGAAAATGATGTTCCAATGTTGGGA
    GTCTGCTTGGGAATGCAGTTGACATGTATCGAGTTTGCTCGTCACGTTTTAGGTCTTGAA
    GGTGCCAATTCTGCAGAGCTTGCACCAGAAACAAAATACCCTATCATTGATATCATGCGT
    GATCAGATTGATATTGAGGATATGGGTGGAACCCTTCGTTTGGGACTTTATCCGTCTAAG
    TTGAAACGTGGCTCTAAGGCTGCTGCTGCTTATCACAATCAAGAAGTGGTGCAACGCCGT
    CACCGTCACCGTTATGAGTTTAATAATGCCTTCCGTGAGCAGTTTGAGGCAGCAGGTTTT
    GTCTTTTCAGGAGTTTCTCCAGACAATCGTTTGGTAGAAATCGTGGAAATTCCTGAAAAT
    AAATTCTTTGTAGCTTGTCAGTATCACCCTGAACTGTCAAGCCGTCCAAACCGACCAGAA
    GAACTCTACACTGCCTTTGTTACTGCAGCGGTTGAGAACAGCAATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1608

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_RS02345 [old locus tag: SPJ_0464 ]
  • symbol: SPJ_RS02345
  • description: CTP synthase
  • length: 535
  • theoretical pI: 5.51695
  • theoretical MW: 59214.3
  • GRAVY: -0.199065

⊟Function[edit | edit source]

  • reaction:
    EC 6.3.4.2?  ExPASy
    CTP synthase (glutamine hydrolyzing) ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis CTP synthase (TIGR00337; EC 6.3.4.2; HMM-score: 833.3)
    and 8 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis GMP synthase (glutamine-hydrolyzing), N-terminal domain (TIGR00888; EC 6.3.5.2; HMM-score: 33.2)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis carbamoyl-phosphate synthase, small subunit (TIGR01368; EC 6.3.5.5; HMM-score: 32.6)
    Metabolism Amino acid biosynthesis Histidine family imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (TIGR01855; EC 2.4.2.-; HMM-score: 23.3)
    glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase (TIGR00566; HMM-score: 18)
    aminodeoxychorismate synthase (TIGR01823; EC 2.6.1.85; HMM-score: 15.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin cobyric acid synthase CobQ (TIGR00313; EC 6.3.5.10; HMM-score: 13.3)
    Metabolism Amino acid biosynthesis Aromatic amino acid family anthranilate synthase (TIGR01815; EC 4.1.3.27; HMM-score: 12.3)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylformylglycinamidine synthase I (TIGR01737; EC 6.3.5.3; HMM-score: 11.7)
  • TheSEED: see SPJ_0464
  • PFAM:
    P-loop_NTPase (CL0023) CTP_synth_N; CTP synthase N-terminus (PF06418; HMM-score: 423.4)
    and 6 more
    Glutaminase_I (CL0014) GATase; Glutamine amidotransferase class-I (PF00117; HMM-score: 193.3)
    Peptidase_C26; Peptidase C26 (PF07722; HMM-score: 34)
    P-loop_NTPase (CL0023) CbiA; CobQ/CobB/MinD/ParA nucleotide binding domain (PF01656; HMM-score: 18.6)
    Glutaminase_I (CL0014) GATase_3; CobB/CobQ-like glutamine amidotransferase domain (PF07685; HMM-score: 15.5)
    no clan defined GerPC; Spore germination protein GerPC (PF10737; HMM-score: 15.3)
    MA-Mit; Mycoplasma arthritidis-derived mitogen (PF09245; HMM-score: 12.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.924
    • Cytoplasmic Membrane Score: 0.0076
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0682
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.043531
    • TAT(Tat/SPI): 0.005839
    • LIPO(Sec/SPII): 0.032235
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKERRGEYLGATVQVIPHITDALKEKIKRAALTTDSDVIITEVGGTVGDIESLPFLEALRQMKADVGADNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPAGQGIKNKLAQFCDVAPEAVIESLDVEHLYQIPLNLQAQGMDQIVCDHLKLDAPAAAMTEWSAMVDKVMNLKKQVKISLVGKYVELQDAYISVVEALKHSGYVNDTEVKINWVNANDVTAENVAELLSDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGVCLGMQLTCIEFARHVLGLEGANSAELAPETKYPIIDIMRDQIDIEDMGGTLRLGLYPSKLKRGSKAAAAYHNQEVVQRRHRHRYEFNNAFREQFEAAGFVFSGVSPDNRLVEIVEIPENKFFVACQYHPELSSRPNRPEELYTAFVTAAVENSN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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