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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_RS03120 [old locus tag: SPJ_0623 ]
  • pan locus tag?: PNEUPAN001588000
  • symbol: hflX
  • pan gene symbol?: hflX
  • synonym:
  • product: GTPase HflX

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_RS03120 [old locus tag: SPJ_0623 ]
  • symbol: hflX
  • product: GTPase HflX
  • replicon: chromosome
  • strand: +
  • coordinates: 608828..610066
  • length: 1239
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGATTGAAACGGAGAAAAAAGAGGAGCGAGTCCTGCTGATTGGTGTGGAATTGCAGGGT
    ATGGACAGTTTTGACCTCTCCATGGAAGAATTGGCTAGTTTAGCGAAAACGGCAGGGGCA
    GTCGTTGTAGATAGCTACAGACAAAAACGTGAAAAATATGATTCCAAGACCTTCGTCGGC
    TCTGGTAAGTTGGAAGAGATTGCGCTTATGGTGGATGCAGAAGAAATCACTACTGTCATC
    GTCAACAATCGTCTGACCCCAAGGCAGAATGTCAATCTAGAGGAAGTTCTCGGTGTTAAG
    GTCATTGACCGTATGCAGTTGATTTTGGATATCTTTGCCATGCGGGCTCGAAGCCATGAA
    GGGAAGCTCCAAGTCCACCTAGCCCAACTCAAATACCTCTTGCCTCGCTTGGTTGGTCAG
    GGGATTATGCTCAGCCGTCAGGCAGGGGGAATTGGTTCCCGTGGTCCTGGTGAAAGCCAA
    CTGGAGCTGAACCGTCGTAGCGTTCGCAATCAAATCACGGATATCGAGCGCCAGCTTAAG
    GTGGTTGAGAAAAATCGTGCGACTGTCAGAGAAAAACGTTTGGAGTCTAGCACTTTTAAG
    ATTGGTTTGATTGGTTATACTAATGCTGGGAAATCAACTATCATGAACATCTTGACCAGT
    AAGACCCAGTATGAAGCAGATGAGCTCTTTGCGACTCTGGATGCGACAACCAAGAGTATT
    CATCTGGGAGGCAATCTCCAAGTAACTTTGACAGATACCGTTGGCTTTATCCAAGATTTG
    CCGACAGAGTTGGTGTCCAGTTTCAAGTCAACCTTGGAAGAAAGCAAGCATGTGGACCTT
    CTGGTTCATGTTATCGATGCTAGCAATCCTTACCACGAGGAGCATGAAAAAACGGTTCTC
    TCCATCATGAAAGACCTGGACATGGAAGATATTCCTCACTTGACGCTTTATAATAAAGCG
    GATTTGGTGGAGGATTTCACGCCTACCCAAACGCCATATACCCTCATTTCTGCCAAGTCT
    GAGGACAGTCGTGAAAACTTGCAAGCATTATTGCTAGATAAGATTAAGGAAATTTTTGAA
    GCATTTACCCTGCGAGTGCCTTTTTCAAAGTCCTACAAGATTCATGATTTAGAGAGTGTT
    GCAATTCTGGAAGAACGTGATTATCAGGAAGACGGCGAAGTGATTACAGGCTACATTTCC
    GAGAAAAATAAATGGAGGTTAGAAGAATTTTATGACTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1239

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_RS03120 [old locus tag: SPJ_0623 ]
  • symbol: HflX
  • description: GTPase HflX
  • length: 412
  • theoretical pI: 4.89895
  • theoretical MW: 46711.9
  • GRAVY: -0.335437

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function General GTP-binding protein HflX (TIGR03156; HMM-score: 437.7)
    and 11 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA modification GTPase TrmE (TIGR00450; EC 3.6.-.-; HMM-score: 57.8)
    Genetic information processing Protein fate Protein modification and repair [FeFe] hydrogenase H-cluster maturation GTPase HydF (TIGR03918; HMM-score: 49.4)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 47)
    Genetic information processing Protein synthesis Other ribosome-associated GTPase EngA (TIGR03594; HMM-score: 45.4)
    Genetic information processing Protein synthesis Other Obg family GTPase CgtA (TIGR02729; HMM-score: 37.5)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YlqF (TIGR03596; HMM-score: 35.1)
    Genetic information processing Protein synthesis Other GTP-binding protein Era (TIGR00436; HMM-score: 34.2)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YsxC (TIGR03598; HMM-score: 26.4)
    Metabolism Transport and binding proteins Cations and iron carrying compounds ferrous iron transport protein B (TIGR00437; HMM-score: 17.5)
    Unknown function General GTP-binding protein YchF (TIGR00092; HMM-score: 15.7)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTPase YqeH (TIGR03597; HMM-score: 15.1)
  • TheSEED: see SPJ_0623
  • PFAM:
    no clan defined GTP-bdg_N; GTP-binding GTPase N-terminal (PF13167; HMM-score: 110.6)
    GTP-bdg_M; GTP-binding GTPase Middle Region (PF16360; HMM-score: 100.4)
    and 12 more
    P-loop_NTPase (CL0023) MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 68.5)
    Arf; ADP-ribosylation factor family (PF00025; HMM-score: 28.7)
    Gtr1_RagA; Gtr1/RagA G protein conserved region (PF04670; HMM-score: 28.5)
    FeoB_N; Ferrous iron transport protein B (PF02421; HMM-score: 23.2)
    GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 20.5)
    ABC_tran; ABC transporter (PF00005; HMM-score: 19.7)
    Ras; Ras family (PF00071; HMM-score: 17.5)
    cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 16)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 14.8)
    G-alpha; G-protein alpha subunit (PF00503; HMM-score: 13.1)
    HTH (CL0123) ANAPC2; Anaphase promoting complex (APC) subunit 2 (PF08672; HMM-score: 13)
    P-loop_NTPase (CL0023) Dynamin_N; Dynamin family (PF00350; HMM-score: 12.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9584
    • Cytoplasmic Membrane Score: 0.0383
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0032
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005684
    • TAT(Tat/SPI): 0.002282
    • LIPO(Sec/SPII): 0.000691
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MIETEKKEERVLLIGVELQGMDSFDLSMEELASLAKTAGAVVVDSYRQKREKYDSKTFVGSGKLEEIALMVDAEEITTVIVNNRLTPRQNVNLEEVLGVKVIDRMQLILDIFAMRARSHEGKLQVHLAQLKYLLPRLVGQGIMLSRQAGGIGSRGPGESQLELNRRSVRNQITDIERQLKVVEKNRATVREKRLESSTFKIGLIGYTNAGKSTIMNILTSKTQYEADELFATLDATTKSIHLGGNLQVTLTDTVGFIQDLPTELVSSFKSTLEESKHVDLLVHVIDASNPYHEEHEKTVLSIMKDLDMEDIPHLTLYNKADLVEDFTPTQTPYTLISAKSEDSRENLQALLLDKIKEIFEAFTLRVPFSKSYKIHDLESVAILEERDYQEDGEVITGYISEKNKWRLEEFYD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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