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JJA
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serotype 1

NCBI: 20-APR-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae JJA
  • locus tag: SPJ_RS04775 [old locus tag: SPJ_0954 ]
  • pan locus tag?: PNEUPAN002099000
  • symbol: SPJ_RS04775
  • pan gene symbol?: asd
  • synonym:
  • product: aspartate-semialdehyde dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPJ_RS04775 [old locus tag: SPJ_0954 ]
  • symbol: SPJ_RS04775
  • product: aspartate-semialdehyde dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 911918..912994
  • length: 1077
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGGGATATACAGTTGCTGTAGTCGGCGCGACAGGTGCTGTCGGTGCTCAGATGATAAAA
    ATGTTGGAAGAATCAACACTTCCAATCGATAAAATCCGTTACCTTGCTTCTGCACGTTCA
    GCAGGTAAGTCATTGAAATTTAAAGATCAAGATATTACGATTGAAGAAACGACTGAAACA
    GCTTTTGAAGGAGTTGATATTGCTCTCTTTTCAGCAGGTGGTTCGACATCAGCTAAGTAT
    GCACCATACGCAGTAAAAGCTGGCGTGGTAGTAGTGGATAATACATCTTATTTCCGTCAA
    AATCCAGATGTTCCTTTGGTTGTTCCAGAGGTCAATGCTCATGCACTTGATGCCCACAAC
    GGAATCATTGCCTGCCCTAACTGTTCAACAATCCAAATGATGGTGGCTCTTGAGCCGGTT
    CGCCAAAAATGGGGCTTGGACCGTATCATTGTTTCAACTTATCAAGCCGTTTCAGGTGCT
    GGTATGGGAGCAATTCTTGAGACACAACGTGAACTTCGTGAGGTCTTGAATGATGGAGTG
    AAACCACGTGATTTGCATGCGGAAATCTTGCCTTCAGGTGGTGACAAGAAACATTATCCT
    ATCGCCTTTAACGCTCTTCCACAAATTGATGTCTTCACTGATAATGATTACACGTACGAA
    GAGATGAAGATGACCAAGGAAACTAAGAAAATTATGGAAGATGATAGCATTGCAGTATCT
    GCGACATGTGTGCGTATTCCAGTCTTGTCAGCTCACTCTGAGTCAGTTTATATTGAAACA
    AAGGAAGTGGCTCCAATTGAAGAAGTCAAAGCAGCTATCGCATCCTTCCCAGGTGCTGTT
    CTTGAAGATGATGTAGTTCATCAAATCTATCCTCAAGCCATCAATGCAGTTGGTTCACGT
    GATACCTTTGTTGGTCGTATCCGTAAAGACTTGGATGCAGAAAAAGGAATTCACATGTGG
    GTTGTTTCAGATAACCTTCTCAAAGGTGCTGCTTGGAACTCAGTTCAGATTGCTGAAACT
    CTTCATGAACGTGGATTGGTTCGTCCAACAGCTGAATTGAAATTTGAATTAAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1077

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPJ_RS04775 [old locus tag: SPJ_0954 ]
  • symbol: SPJ_RS04775
  • description: aspartate-semialdehyde dehydrogenase
  • length: 358
  • theoretical pI: 4.9468
  • theoretical MW: 38991.3
  • GRAVY: -0.0645251

⊟Function[edit | edit source]

  • reaction:
    EC 1.2.1.11?  ExPASy
    Aspartate-semialdehyde dehydrogenase L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aspartate family aspartate-semialdehyde dehydrogenase (TIGR01296; EC 1.2.1.11; HMM-score: 446.1)
    and 5 more
    Metabolism Amino acid biosynthesis Aspartate family aspartate-semialdehyde dehydrogenase (TIGR00978; EC 1.2.1.11; HMM-score: 146.7)
    Metabolism Amino acid biosynthesis Aspartate family aspartate-semialdehyde dehydrogenase (TIGR01745; EC 1.2.1.11; HMM-score: 83.3)
    Metabolism Amino acid biosynthesis Glutamate family N-acetyl-gamma-glutamyl-phosphate reductase (TIGR01850; EC 1.2.1.38; HMM-score: 59.5)
    Metabolism Energy metabolism Glycolysis/gluconeogenesis glyceraldehyde-3-phosphate dehydrogenase, type I (TIGR01534; EC 1.2.1.-; HMM-score: 14.8)
    Metabolism Central intermediary metabolism Other long-chain fatty acyl-ACP reductase (aldehyde-forming) (TIGR04058; EC 1.1.1.-; HMM-score: 14.1)
  • TheSEED: see SPJ_0954
  • PFAM:
    GADPH_aa-bio_dh (CL0139) Semialdhyde_dhC; Semialdehyde dehydrogenase, dimerisation domain (PF02774; HMM-score: 180.8)
    and 5 more
    NADP_Rossmann (CL0063) Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain (PF01118; HMM-score: 109.8)
    DapB_N; Dihydrodipicolinate reductase, N-terminus (PF01113; HMM-score: 20.8)
    GADPH_aa-bio_dh (CL0139) Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain (PF02800; HMM-score: 17.2)
    NADP_Rossmann (CL0063) NAD_binding_10; NAD(P)H-binding (PF13460; HMM-score: 16.8)
    Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 13.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.030212
    • TAT(Tat/SPI): 0.001671
    • LIPO(Sec/SPII): 0.013621
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MGYTVAVVGATGAVGAQMIKMLEESTLPIDKIRYLASARSAGKSLKFKDQDITIEETTETAFEGVDIALFSAGGSTSAKYAPYAVKAGVVVVDNTSYFRQNPDVPLVVPEVNAHALDAHNGIIACPNCSTIQMMVALEPVRQKWGLDRIIVSTYQAVSGAGMGAILETQRELREVLNDGVKPRDLHAEILPSGGDKKHYPIAFNALPQIDVFTDNDYTYEEMKMTKETKKIMEDDSIAVSATCVRIPVLSAHSESVYIETKEVAPIEEVKAAIASFPGAVLEDDVVHQIYPQAINAVGSRDTFVGRIRKDLDAEKGIHMWVVSDNLLKGAAWNSVQIAETLHERGLVRPTAELKFELK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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