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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 20-APR-2021
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae JJA
- locus tag: SPJ_RS08835 [old locus tag: SPJ_1777 ]
- pan locus tag?: PNEUPAN003365000
- symbol: SPJ_RS08835
- pan gene symbol?: piuA
- synonym:
- product: siderophore ABC transporter substrate-binding protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPJ_RS08835 [old locus tag: SPJ_1777 ]
- symbol: SPJ_RS08835
- product: siderophore ABC transporter substrate-binding protein
- replicon: chromosome
- strand: +
- coordinates: 1696635..1697600
- length: 966
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_012466 (1696635..1697600) NCBI
- BioCyc: SPJ_RS08835 BioCyc
- MicrobesOnline: see SPJ_1777
- PneumoBrowse for strain D39V: SPV_1652 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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961ATGAAAACATCCCTTAAACTTTATTTCACTGCCCTAGTGGCCAGCTTCTTGCTCCTACTT
GGTGCATGTAGTACAAACTCAAGCACTAGTCAGACAGAGACCAGTAGCTCTGCTCCAACA
GAGGTAACCATTAAAAGTTCACTGGACGAGGTCAAACTTTCCAAAGTTCCTGAAAAGATT
GTGACCTTTGACCTCGGCGCTGCGGATACTATTCGCGCTTTAGGATTTGAAAAAAATATC
GTCGGAATGCCTACAAAAACTGTTCCGACTTATCTAAAAGACCTAGTGGGAACTGTCAAA
AATGTTGGTTCTATGAAAGAACCTGATTTAGAAGCTATCGCCGCCCTTGAGCCTGATTTG
ATTATCGCTTCACCACGTACACAAAAATTCGTAGACAAATTCAAAGAAATCGCCCCAACC
GTTCTCTTCCAAGCAAGCAAGGACGACTACTGGACTTCTACCAAGGCTAATATCGAATCC
TTAGCAAGTGCCTTCGGCGAAACTGGTACACAGAAAGCCAAGGAAGAATTGGCCAAGCTA
GACAAGAGCATCCAAAAAGTCGCTACTAAAAATGAAAGCTCTGACAAAAAGGCCCTTGCG
ATCCTCCTTAATGAAGGAAAAATGGCAGCCTTTGGTGCCAAATCTCGTTTCTCTTTCTTG
TACCAAACCTTGAAATTCAAACCAACTGATACAACATTTGAAGACTCACGCCACGGACAA
GAAGTCAGCTTTGAAAGTGTCAAAGAAATCAACCCTGACATCCTCTTTGTCATCAACCGT
ACCCTTGCCATCGGTGGGGACAACTCTAGCAACGACGGTGTCCTAGAAAATGCCCTTATC
GCTGAAACACCTGCTGCTAAAAATGGTAAGATTATCCAACTAACACCAGACCTCTGGTAT
CTAAGCGGAGGCGGACTTGAATCAACAAAACTCATGATTGAAGACATACAAAAAGCTTTG
AAATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPJ_RS08835 [old locus tag: SPJ_1777 ]
- symbol: SPJ_RS08835
- description: siderophore ABC transporter substrate-binding protein
- length: 321
- theoretical pI: 5.58221
- theoretical MW: 34790.6
- GRAVY: -0.161682
⊟Function[edit | edit source]
- TIGRFAM: heme ABC transporter, heme-binding protein isdE (TIGR03659; HMM-score: 55.7)putative ABC transporter PGF-CTERM-modified substrate-binding protein (TIGR04281; HMM-score: 50.5)and 2 moreproposed F420-0 ABC transporter, periplasmic F420-0 binding protein (TIGR03868; HMM-score: 23.8)Protein fate Protein and peptide secretion and trafficking Arg-Lys translocation region protein phosphatase (TIGR04400; EC 3.1.3.-; HMM-score: 12.1)
- TheSEED: see SPJ_1777
- PFAM: Chelatase (CL0043) Peripla_BP_2; Periplasmic binding protein (PF01497; HMM-score: 120.3)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic Membrane
- Cytoplasmic Score: 0.17
- Cytoplasmic Membrane Score: 9.51
- Cellwall Score: 0.16
- Extracellular Score: 0.15
- Internal Helix: 1
- SignalP: Signal peptide LIPO(Sec/SPII) length 22 aa
- SP(Sec/SPI): 0.000583
- TAT(Tat/SPI): 0.00007
- LIPO(Sec/SPII): 0.999223
- Cleavage Site: CS pos: 22-23. LGA-CS. Pr: 0.9994
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MKTSLKLYFTALVASFLLLLGACSTNSSTSQTETSSSAPTEVTIKSSLDEVKLSKVPEKIVTFDLGAADTIRALGFEKNIVGMPTKTVPTYLKDLVGTVKNVGSMKEPDLEAIAALEPDLIIASPRTQKFVDKFKEIAPTVLFQASKDDYWTSTKANIESLASAFGETGTQKAKEELAKLDKSIQKVATKNESSDKKALAILLNEGKMAAFGAKSRFSFLYQTLKFKPTDTTFEDSRHGQEVSFESVKEINPDILFVINRTLAIGGDNSSNDGVLENALIAETPAAKNGKIIQLTPDLWYLSGGGLESTKLMIEDIQKALK
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator: CodY see SPJ_1777
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1652 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Maha Jomaa, Jose Yuste, James C Paton, Christopher Jones, Gordon Dougan, Jeremy S Brown
Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae.
Infect Immun: 2005, 73(10);6852-9
[PubMed:16177364] [WorldCat.org] [DOI] (P p)