From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN032672
  • locus tag: SPN032672_RS08090
  • pan locus tag?: PNEUPAN001151000
  • symbol: SPN032672_RS08090
  • pan gene symbol?: cps2K
  • synonym:
  • product: nucleotide sugar dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN032672_RS08090
  • symbol: SPN032672_RS08090
  • product: nucleotide sugar dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 1504994..1506226
  • length: 1233
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021003 (1504994..1506226) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0326 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGAAAATAGCAGTAGCAGGTACAGGATATGTTGGATTATCTATTGCAATCTTACTGGCT
    CAACATCATCAAGTTGTTGCCGTAGATATCATTCCTGAGAAAGTTGAGTTAATCAATAAA
    AAGAAGTCCCCTATCCAAGACGATTATATAGAAAAATATCTCGCGGAAAAAGAATTGAAT
    CTCGTAGCTACATTGAATGCAGAGGAAGCATATGAGAATGCGGATTTTATAGTTATTGCG
    GCTCCAACTAATTATGATCCGAAAAAAAATTTTTTCGATACATCTTCAGTCGAGGCTGTC
    ATTGAAGCAGTTATGAAATATAATCCTGATGCAATTATAATAATTAAAAGTACTGTTCCT
    GTTGGATATACAAAGTCAGTACGGAGGAAATTTCTTACAGACAATATTATGTTTAGTCCT
    GAGTTTTTACGGGAGTCAAAAGCGTTATATGATAACCTATATCCGAGTCGAATTATTATA
    GGTACAGATAAAGATGATAAAGATTTGGTAAAGTCTGCTGAAATTTTTGTAAAAATGCTT
    CAGGAAGGTGCAGTGAAAGAAAATATTGAAACATTGTATATGGATTTTACAGAAGCTGAA
    GCAGTAAAACTTTTTGCTAATACCTATCTTGCCCTCCGGGTTTCCTATTTTAACGAGTTA
    GATACTTATTCTGAGATGAAAGGACTAGATACTCAAGCGATTATTGATGGAGTTTGTTTA
    GATCCGAGAATAGGTTCTCACTACAATAATCCTTCTTTTGGTTATGGGGGTTACTGTCTT
    CCTAAAGATACCAAGCAACTTCTTGCAAATTATTCTGACGTTCCACAAGAAATGATAACA
    GCTATAGTACAAAGTAATCGGACAAGAAAAGATTATATTGCAGATCGTATTTTAGATCTT
    GCTGGATCTTATGTAGGCAATGATTTCTATAAACCAGATAAAGAAAAAGAGATTGTTGTA
    GGAATTTATCGTTTAACAATGAAAAGTAATTCAGATAATTTTAGACAATCTTCTATTCAA
    GGTATTATGAAGCGTTTGAAAGCAAAAGGTGTTACTATTATTATTTACGAACCAACTCTT
    GAAAGTGGTACTACTTTCTATGGTAGTCAAGTAGTTAATGATTTTGAAATATTTAAGAAA
    TCTAGTCAAGTGATTGTTGCAAATCGTTTTGATGAGACTTTAGAAGATGTGAGGGGTAAA
    GTTTATACTAGGGATATTTTTAAGAGAGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1233

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN032672_RS08090
  • symbol: SPN032672_RS08090
  • description: nucleotide sugar dehydrogenase
  • length: 410
  • theoretical pI: 5.03175
  • theoretical MW: 46414.7
  • GRAVY: -0.228537

⊟Function[edit | edit source]

  • TIGRFAM:
    nucleotide sugar dehydrogenase (TIGR03026; HMM-score: 323.8)
    and 6 more
    Metabolism Energy metabolism TCA cycle malate dehydrogenase, NAD-dependent (TIGR01763; EC 1.1.1.37; HMM-score: 21)
    Metabolism Amino acid biosynthesis Glutamate family N-acetyl-gamma-glutamyl-phosphate reductase (TIGR01850; EC 1.2.1.38; HMM-score: 13.8)
    glycerol-3-phosphate dehydrogenase (NAD(+)) (TIGR03376; EC 1.1.1.8; HMM-score: 13.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A 2-dehydropantoate 2-reductase (TIGR00745; EC 1.1.1.-; HMM-score: 13.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family (TIGR01988; EC 1.14.13.-; HMM-score: 10.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides L-aspartate oxidase (TIGR00551; EC 1.4.3.16; HMM-score: 8.9)
  • TheSEED: data available for D39
  • PFAM:
    NADP_Rossmann (CL0063) UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 117.9)
    and 16 more
    6PGD_C (CL0106) UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain (PF00984; HMM-score: 91.2)
    HUP (CL0039) UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain (PF03720; HMM-score: 43.8)
    NADP_Rossmann (CL0063) NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus (PF01210; HMM-score: 28.1)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 28)
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 23.9)
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase (PF03446; HMM-score: 20.6)
    Ldh_1_N; lactate/malate dehydrogenase, NAD binding domain (PF00056; HMM-score: 20.3)
    TrkA_N; TrkA-N domain (PF02254; HMM-score: 20.3)
    no clan defined DUF1433; Protein of unknown function (DUF1433) (PF07252; HMM-score: 17.3)
    NADP_Rossmann (CL0063) Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 16.9)
    Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain (PF01118; HMM-score: 16.3)
    ApbA; Ketopantoate reductase PanE/ApbA (PF02558; HMM-score: 16.1)
    Methyltransf_16; Lysine methyltransferase (PF10294; HMM-score: 14.2)
    P-loop_NTPase (CL0023) Thymidylate_kin; Thymidylate kinase (PF02223; HMM-score: 13.6)
    NADP_Rossmann (CL0063) Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 12.6)
    DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 11.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9428
    • Cytoplasmic Membrane Score: 0.0196
    • Cell wall & surface Score: 0.0023
    • Extracellular Score: 0.0354
  • SignalP: Signal peptide SP(Sec/SPI) length 27 aa
    • SP(Sec/SPI): 0.885502
    • TAT(Tat/SPI): 0.001053
    • LIPO(Sec/SPII): 0.007408
    • Cleavage Site: CS pos: 27-28. VVA-VD. Pr: 0.8420
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000685088 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKIAVAGTGYVGLSIAILLAQHHQVVAVDIIPEKVELINKKKSPIQDDYIEKYLAEKELNLVATLNAEEAYENADFIVIAAPTNYDPKKNFFDTSSVEAVIEAVMKYNPDAIIIIKSTVPVGYTKSVRRKFLTDNIMFSPEFLRESKALYDNLYPSRIIIGTDKDDKDLVKSAEIFVKMLQEGAVKENIETLYMDFTEAEAVKLFANTYLALRVSYFNELDTYSEMKGLDTQAIIDGVCLDPRIGSHYNNPSFGYGGYCLPKDTKQLLANYSDVPQEMITAIVQSNRTRKDYIADRILDLAGSYVGNDFYKPDKEKEIVVGIYRLTMKSNSDNFRQSSIQGIMKRLKAKGVTIIIYEPTLESGTTFYGSQVVNDFEIFKKSSQVIVANRFDETLEDVRGKVYTRDIFKRD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SPN032672_RS08090&oldid=136891"