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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN032672
  • locus tag: SPN032672_RS10945
  • pan locus tag?: PNEUPAN001939000
  • symbol: proC
  • pan gene symbol?: proC
  • synonym:
  • product: pyrroline-5-carboxylate reductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN032672_RS10945
  • symbol: proC
  • product: pyrroline-5-carboxylate reductase
  • replicon: chromosome
  • strand: +
  • coordinates: 2053723..2054520
  • length: 798
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021003 (2053723..2054520) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0824 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGAAGATTGGATTTATCGGTTTGGGGAATATGGGTGCTAGTTTAACCAAGTCTGTCTTG
    CAGGCTAGACCGTCAGATGAGATTCTCCTTGCCAATCGTAGTCAAGTCAAGGTGGATGCT
    TTCATCGCTAACTTCGGTGGTCAGACTTCTAACAATGAAGAAATATTCGAAGAAGCAGAT
    GTGATTTTTCTAGGTGTTAAGCCTGCTCAGTTTTCTGAACTGCTTTCTCAATACCAGACC
    ATCCTTGAAAAAAGAGAAAGTCTTCTTTTGATTTCGATGGCAGCTGGATTGACCTTAGAA
    AAACTAGCAAGTCTTATCCCAAGCCAACACCGAATTATTCGTATGATGCCTAATACCCCT
    GCTTCTATCGGGCAAGGAGTGATTAGTTATGCCTTGTCTCCTAATTGCAGGGCTGAGGAC
    AGTGAGATCTTTTGTCAGCTTTTAGCCAAGGCTGGTCTCTTGGTTGAATTAGGAGAAAGC
    TTAATCAATGCAGCGACAGGTCTTGCAGGTTGTGGACCAGCCTTTGTCTATCTCTTTATT
    GAGGCCTTGGCAGATGCAGGTGTTCAGACGGGATTACCACGAGAAACAGCCTTGAAAATG
    GCAGCCCAAACTGTGGTAGGAGCTGGGCAATTGGTCCTAGAAAGCCAGCAACATCCTGGA
    GTTTTGAAAGATCAAGTTTGTAGTCCAGGCGGTTCGACTATTGCTGGCGTAGCAAGCCTA
    GAAGCGCATGCTTTTCGAGGCACAGTCATGGAGGCAGTTCATCAAGCCTATAAACGAACA
    CAAGAACTAGGTAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    798

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN032672_RS10945
  • symbol: ProC
  • description: pyrroline-5-carboxylate reductase
  • length: 265
  • theoretical pI: 5.33986
  • theoretical MW: 28042.2
  • GRAVY: 0.209057

⊟Function[edit | edit source]

  • reaction:
    EC 1.5.1.2?  ExPASy
    Pyrroline-5-carboxylate reductase L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Glutamate family pyrroline-5-carboxylate reductase (TIGR00112; EC 1.5.1.2; HMM-score: 298.4)
    and 4 more
    2-hydroxy-3-oxopropionate reductase (TIGR01505; EC 1.1.1.60; HMM-score: 27.6)
    Metabolism Energy metabolism Pentose phosphate pathway 6-phosphogluconate dehydrogenase (decarboxylating) (TIGR00872; EC 1.1.1.44; HMM-score: 16.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin glutamyl-tRNA reductase (TIGR01035; EC 1.2.1.70; HMM-score: 14.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A 2-dehydropantoate 2-reductase (TIGR00745; EC 1.1.1.-; HMM-score: 14.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    6PGD_C (CL0106) P5CR_dimer; Pyrroline-5-carboxylate reductase dimerisation (PF14748; HMM-score: 140.9)
    and 8 more
    NADP_Rossmann (CL0063) F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 61.3)
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase (PF03446; HMM-score: 37.6)
    Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 26)
    ApbA; Ketopantoate reductase PanE/ApbA (PF02558; HMM-score: 18.6)
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 18.2)
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain (PF03435; HMM-score: 13.8)
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus (PF01210; HMM-score: 13.3)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 11.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.95
    • Cytoplasmic Membrane Score: 0.05
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.082509
    • TAT(Tat/SPI): 0.004994
    • LIPO(Sec/SPII): 0.006898
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000689717 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKIGFIGLGNMGASLTKSVLQARPSDEILLANRSQVKVDAFIANFGGQTSNNEEIFEEADVIFLGVKPAQFSELLSQYQTILEKRESLLLISMAAGLTLEKLASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRAEDSEIFCQLLAKAGLLVELGESLINAATGLAGCGPAFVYLFIEALADAGVQTGLPRETALKMAAQTVVGAGQLVLESQQHPGVLKDQVCSPGGSTIAGVASLEAHAFRGTVMEAVHQAYKRTQELGK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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