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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN032672
  • locus tag: SPN032672_RS11125
  • pan locus tag?: PNEUPAN001996000
  • symbol: era
  • pan gene symbol?: era
  • synonym:
  • product: GTPase Era

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN032672_RS11125
  • symbol: era
  • product: GTPase Era
  • replicon: chromosome
  • strand: +
  • coordinates: 2082050..2082922
  • length: 873
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021003 (2082050..2082922) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0857 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATTTTAGGACGTCCCAATGTTGGGAAGTCAACCTTTTTAAATCACGTTATGGGGCAAAAG
    ATTGCCATCATGAGTGACAAGGCGCAGACAACGCGCAATAAAATCATGGGAATTTACACG
    ACTGATAAGGAGCAAATTGTCTTTATCGACACACCAGGGATTCACAAACCTAAAACAGCT
    CTCGGAGATTTCATGGTTGAGTCTGCCTACAGTACCCTTCGCGAAGTGGACACTGTTCTT
    TTCATGGTGCCTGCTGATGAAGCGCGTGGTAAGGGGGACGATATGATTATCGAGCGTCTC
    AAGGCTGCCAAGGTTCCTGTGATTTTGGTGGTGAATAAAATCGATAAGGTCCATCCAGAC
    CAGCTCTTGTCTCAGATTGATGACTTCCGTAATCAAATGGACTTTAAGGAAATTGTTCCA
    ATCTCAGCCCTTCAGGGAAATAACGTGTCTCGTCTAGTGGATATTTTGAGTGAAAATCTG
    GATGAAGGTTTCCAATATTTCCCGTCTGATCAAATCACAGACCATCCAGACCGTTTCTTA
    GTTTCAGAAATGGTTCGCGAGAAAGTCTTGCACCTAACTCGTGAAGAGATTCCGCATTCT
    GTAGCAGTAGTTGTTGACTCTATGAAACGAGACGAAGAGACAGACAAGGTTCACATCCGT
    GCAACCATCATGGTCGAGCGCGATAGCCAAAAAGGGATTATCATCGGTAAAGGTGGCGCT
    ATGCTTAAGAAAATCGGTAGCATGGCCCGTCGTGATATCGAACTCATGCTAGGAGACAAG
    GTCTTCCTAGAAACCTGGGTCAAGGTCAAGAAAAACTGGCGCGATAAAAAGCTAGATTTG
    GCTGACTTTGGCTATAATGAAAGAGAATACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    873

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN032672_RS11125
  • symbol: Era
  • description: GTPase Era
  • length: 290
  • theoretical pI: 6.64733
  • theoretical MW: 33045
  • GRAVY: -0.330345

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis Other GTP-binding protein Era (TIGR00436; HMM-score: 343.9)
    and 20 more
    Genetic information processing Protein synthesis Other ribosome-associated GTPase EngA (TIGR03594; HMM-score: 121.1)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 108.2)
    Genetic information processing Protein fate Protein modification and repair [FeFe] hydrogenase H-cluster maturation GTPase HydF (TIGR03918; HMM-score: 86)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA modification GTPase TrmE (TIGR00450; EC 3.6.-.-; HMM-score: 66.7)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YsxC (TIGR03598; HMM-score: 56.3)
    Metabolism Transport and binding proteins Cations and iron carrying compounds ferrous iron transport protein B (TIGR00437; HMM-score: 51.7)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YlqF (TIGR03596; HMM-score: 51)
    Genetic information processing Protein synthesis Translation factors translation initiation factor IF-2 (TIGR00487; HMM-score: 47.9)
    Unknown function General GTP-binding protein HflX (TIGR03156; HMM-score: 44.5)
    Genetic information processing Protein synthesis Other Obg family GTPase CgtA (TIGR02729; HMM-score: 42)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTPase YqeH (TIGR03597; HMM-score: 29.3)
    Genetic information processing Protein synthesis Translation factors ribosome small subunit-dependent GTPase A (TIGR00157; EC 3.6.-.-; HMM-score: 22.2)
    translation initiation factor 2, gamma subunit (TIGR03680; HMM-score: 20.2)
    Cellular processes Cellular processes Adaptations to atypical conditions GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 17.7)
    Genetic information processing Protein synthesis Translation factors GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 17.7)
    Signal transduction Regulatory functions Other GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 17.7)
    Metabolism Central intermediary metabolism Sulfur metabolism sulfate adenylyltransferase, large subunit (TIGR02034; EC 2.7.7.4; HMM-score: 14.9)
    Metabolism Energy metabolism Amino acids and amines ethanolamine utilization protein, EutP (TIGR02528; HMM-score: 14.3)
    Metabolism Transport and binding proteins Nucleosides, purines and pyrimidines GTP-binding protein (TIGR00991; HMM-score: 13.5)
    Metabolism Transport and binding proteins Amino acids, peptides and amines chloroplast protein import component Toc86/159, G and M domains (TIGR00993; HMM-score: 12.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    KH (CL0007) KH_2; KH domain (PF07650; HMM-score: 81.7)
    P-loop_NTPase (CL0023) MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 79.5)
    and 13 more
    FeoB_N; Ferrous iron transport protein B (PF02421; HMM-score: 53)
    GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 42)
    Dynamin_N; Dynamin family (PF00350; HMM-score: 38.6)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 32.3)
    AIG1; AIG1 family (PF04548; HMM-score: 23.8)
    cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 21.2)
    no clan defined MMR_HSR1_Xtn; C-terminal region of MMR_HSR1 domain (PF16897; HMM-score: 20)
    P-loop_NTPase (CL0023) PduV-EutP; Ethanolamine utilisation - propanediol utilisation (PF10662; HMM-score: 19.1)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 14.6)
    RHD3_GTPase; Root hair defective 3 GTP-binding protein (RHD3) GTPase domain (PF05879; HMM-score: 14.5)
    Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 14.4)
    KH (CL0007) KH_1; KH domain (PF00013; HMM-score: 14.1)
    KH_4; KH domain (PF13083; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007857
    • TAT(Tat/SPI): 0.001509
    • LIPO(Sec/SPII): 0.001794
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_078464962 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTDKEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVDTVLFMVPADEARGKGDDMIIERLKAAKVPVILVVNKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVSRLVDILSENLDEGFQYFPSDQITDHPDRFLVSEMVREKVLHLTREEIPHSVAVVVDSMKRDEETDKVHIRATIMVERDSQKGIIIGKGGAMLKKIGSMARRDIELMLGDKVFLETWVKVKKNWRDKKLDLADFGYNEREY

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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