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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 26-AUG-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN034156
  • locus tag: SPN034156_13470 [new locus tag: SPN034156_RS07530 ]
  • pan locus tag?: PNEUPAN001008000
  • symbol: fus
  • pan gene symbol?: fusA
  • synonym:
  • product: elongation factor G (EF-G)

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN034156_13470 [new locus tag: SPN034156_RS07530 ]
  • symbol: fus
  • product: elongation factor G (EF-G)
  • replicon: chromosome
  • strand: +
  • coordinates: 1380953..1383034
  • length: 2082
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: FQ312045 (1380953..1383034) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0253 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    ATGGCACGCGAATTTTCACTTGAAAAAACTCGTAATATCGGTATCATGGCTCACGTCGAT
    GCCGGTAAAACAACAACTACTGAGCGTATTCTTTACTACACTGGTAAAATCCACAAAATC
    GGTGAAACTCACGAAGGTGCGTCACAAATGGACTGGATGGAGCAAGAGCAAGAACGTGGT
    ATCACGATCACATCTGCTGCGACAACAGCTCAATGGAACAACCACCGCGTAAACATCATC
    GACACACCAGGACACGTGGACTTCACAATCGAAGTACAACGTTCTCTTCGTGTATTGGAT
    GGTGCGGTTACCGTTCTTGACTCACAATCAGGTGTTGAGCCTCAAACTGAAACAGTTTGG
    CGTCAAGCAACTGAGTACGGAGTTCCACGTATCGTATTTGCCAACAAAATGGACAAAATC
    GGTGCTGACTTCCTTTACTCTGTAAGCACACTTCACGATCGTCTTCAAGCAAATGCACAC
    CCAATCCAATTGCCAATCGGTTCTGAAGATGACTTCCGTGGTATCATTGACTTGATCAAG
    ATGAAAGCTGAAATCTATACTAACGACCTTGGTACGGATATCCTTGAAGAAGACATCCCA
    GCTGAATACCTTGACCAAGCTCAAGAATACCGTGAAAAATTGATTGAAGCAGTTGCTGAA
    ACTGACGAAGAATTGATGATGAAATACCTCGAAGGTGAAGAAATCACTAACGAAGAATTG
    AAAGCTGGTATCCGTAAAGCGACTATCAACGTTGAATTCTTCCCAGTATTGTGTGGTTCA
    GCCTTCAAAAACAAAGGTGTTCAATTGATGCTTGATGCGGTTATCGACTACCTTCCAAGC
    CCACTTGACATCCCAGCAATCAAAGGTATTAACCCAGATACAGACGCTGAAGAAATTCGT
    CCAGCATCTGACGAAGAGCCATTTGCAGCTCTTGCCTTCAAGATCATGACTGACCCATTC
    GTAGGTCGTTTGACATTCTTCCGTGTTTACTCAGGTGTTCTTCAATCAGGTTCATACGTA
    TTGAATACTTCTAAAGGTAAACGTGAACGTATCGGACGTATCCTTCAAATGCACGCTAAC
    AGCCGTCAAGAAATCGACACTGTTTACTCAGGTGATATCGCTGCTGCCGTTGGTTTGAAA
    GATACTACAACTGGTGACTCATTGACAGATGAAAAAGCTAAAATCATCCTTGAGTCAATC
    AACGTTCCAGAACCAGTTATCCAATTGATGGTTGAGCCAAAATCTAAAGCTGACCAAGAC
    AAGATGGGTATCGCCCTTCAAAAATTGGCTGAAGAAGATCCAACATTCCGCGTTGAAACA
    AACGTTGAAACTGGTGAAACAGTTATCTCAGGTATGGGTGAACTTCACCTTGACGTCCTT
    GTTGATCGTATGCGTCGTGAGTTCAAAGTTGAAGCGAACGTAGGTGCTCCTCAAGTATCT
    TACCGTGAAACATTCCGCGCTTCTACTCAAGCACGTGGATTCTTCAAACGTCAGTCTGGT
    GGTAAAGGTCAATTCGGTGATGTATGGATTGAATTTACTCCAAACGAAGAAGGTAAAGGA
    TTCGAATTCGAAAACGCAATCGTCGGTGGTGTGGTTCCTCGTGAATTTATCCCAGCGGTT
    GAAAAAGGTTTGGTAGAATCTATGGCTAACGGTGTTCTTGCAGGTTACCCAATGGTTGAC
    GTTAAAGCTAAGCTTTATGATGGTTCATATCACGATGTCGACTCATCTGAAACTGCCTTC
    AAGATTGCGGCTTCACTTTCCCTTAAAGAAGCTGCTAAATCAGCACAACCAGCTATCCTT
    GAACCAATGATGCTTGTAACAATCACTGTTCCAGAAGAAAACCTTGGTGATGTTATGGGT
    CACGTAACTGCTCGTCGTGGACGTGTAGATGGTATGGAAGCACACGGTAACAGCCAAATC
    GTTCGTGCTTACGTTCCACTTGCTGAAATGTTCGGTTACGCAACAGTTCTTCGTTCTGCA
    TCTCAAGGACGTGGTACATTCATGATGGTATTTGACCACTACGAAGATGTACCTAAGTCA
    GTACAAGAAGAAATTATTAAGAAAAATAAAGGTGAAGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2082

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN034156_13470 [new locus tag: SPN034156_RS07530 ]
  • symbol: Fus
  • description: elongation factor G (EF-G)
  • length: 693
  • theoretical pI: 4.58479
  • theoretical MW: 76830.5
  • GRAVY: -0.305628

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis Translation factors translation elongation factor G (TIGR00484; HMM-score: 1194)
    and 15 more
    Genetic information processing Protein synthesis Translation factors translation elongation factor aEF-2 (TIGR00490; HMM-score: 340.1)
    Cellular processes Cellular processes Adaptations to atypical conditions GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 253.7)
    Genetic information processing Protein synthesis Translation factors GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 253.7)
    Signal transduction Regulatory functions Other GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 253.7)
    Genetic information processing Protein synthesis Translation factors peptide chain release factor 3 (TIGR00503; HMM-score: 211.2)
    Unknown function General elongation factor 4 (TIGR01393; EC 3.6.5.-; HMM-score: 181.7)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 141)
    Genetic information processing Protein synthesis Translation factors translation elongation factor Tu (TIGR00485; HMM-score: 63.4)
    Genetic information processing Protein synthesis Translation factors translation elongation factor EF-1, subunit alpha (TIGR00483; HMM-score: 62)
    Genetic information processing Protein synthesis Translation factors translation initiation factor IF-2 (TIGR00487; HMM-score: 50.4)
    Genetic information processing Protein synthesis Translation factors selenocysteine-specific translation elongation factor (TIGR00475; HMM-score: 39.7)
    Metabolism Central intermediary metabolism Sulfur metabolism sulfate adenylyltransferase, large subunit (TIGR02034; EC 2.7.7.4; HMM-score: 36.2)
    Genetic information processing Protein synthesis Translation factors translation initiation factor aIF-2 (TIGR00491; HMM-score: 33.7)
    Genetic information processing Protein synthesis Other ribosome-associated GTPase EngA (TIGR03594; HMM-score: 26.3)
    translation initiation factor 2, gamma subunit (TIGR03680; HMM-score: 24.7)
  • TheSEED  :
    • Translation elongation factor G
    Protein Metabolism Protein biosynthesis Translation elongation factor G family  Translation elongation factor G
    and 3 more
    Protein Metabolism Protein biosynthesis Translation elongation factors bacterial  Translation elongation factor G
    Protein Metabolism Protein biosynthesis Universal GTPases  Translation elongation factor G
    Virulence Virulence - no subcategory Mycobacterium virulence operon involved in protein synthesis (SSU ribosomal proteins)  Translation elongation factor G
  • PFAM:
    P-loop_NTPase (CL0023) GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 237.3)
    and 7 more
    S5 (CL0329) EFG_IV; Elongation factor G, domain IV (PF03764; HMM-score: 156.1)
    EF-G_C (CL0437) EFG_III; Elongation Factor G, domain III (PF14492; HMM-score: 115.8)
    EFG_C; Elongation factor G C-terminus (PF00679; HMM-score: 104.5)
    EFTPs (CL0575) GTP_EFTU_D2; Elongation factor Tu domain 2 (PF03144; HMM-score: 53.9)
    EF-G_C (CL0437) RF3_C; Class II release factor RF3, C-terminal domain (PF16658; HMM-score: 26.8)
    P-loop_NTPase (CL0023) MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 24.9)
    AIG1; AIG1 family (PF04548; HMM-score: 15.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 10
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9952
    • Cytoplasmic Membrane Score: 0.0001
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0046
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011025
    • TAT(Tat/SPI): 0.001751
    • LIPO(Sec/SPII): 0.001546
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CCP37016 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWNNHRVNIIDTPGHVDFTIEVQRSLRVLDGAVTVLDSQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVSTLHDRLQANAHPIQLPIGSEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPAEYLDQAQEYREKLIEAVAETDEELMMKYLEGEEITNEELKAGIRKATINVEFFPVLCGSAFKNKGVQLMLDAVIDYLPSPLDIPAIKGINPDTDAEEIRPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVLQSGSYVLNTSKGKRERIGRILQMHANSRQEIDTVYSGDIAAAVGLKDTTTGDSLTDEKAKIILESINVPEPVIQLMVEPKSKADQDKMGIALQKLAEEDPTFRVETNVETGETVISGMGELHLDVLVDRMRREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDVWIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLVESMANGVLAGYPMVDVKAKLYDGSYHDVDSSETAFKIAASLSLKEAAKSAQPAILEPMMLVTITVPEENLGDVMGHVTARRGRVDGMEAHGNSQIVRAYVPLAEMFGYATVLRSASQGRGTFMMVFDHYEDVPKSVQEEIIKKNKGED

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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