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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN034156
  • locus tag: SPN034156_RS01300 [old locus tag: SPN034156_02460 ]
  • pan locus tag?: PNEUPAN002589000
  • symbol: crcB
  • pan gene symbol?: crcB1
  • synonym:
  • product: fluoride efflux transporter CrcB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN034156_RS01300 [old locus tag: SPN034156_02460 ]
  • symbol: crcB
  • product: fluoride efflux transporter CrcB
  • replicon: chromosome
  • strand: -
  • coordinates: 265412..265741
  • length: 330
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021006 (265412..265741) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1149 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    ATGGTAATCGTCTATCTTGCAATCGCCTGTGGCTTGGGAGCACTCGTACGGTATTTCTTT
    TCCCGCTACAATCAAGCTTCTAAATTGCCACTTGGAACGCTCATAGCTAATCTTTTAGGT
    TGTTTTTTAATTGGAGTATTCTACAATCATGTAGAGTCTAAGGAAGTATATGCTATTCTA
    GCAACAGGATTTTGTGGCGGTTTAACAACTTTTTCGACCTTGAATGACGAACTTCAAAGA
    CTGCTAAGTTATAAGAAGGTCTTTTATTCTTACCTGACTTTGACTTACATAGGTGGTTTG
    GTTGCGATTTTTTTAGGAATTTTGCTATAA
    60
    120
    180
    240
    300
    330

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN034156_RS01300 [old locus tag: SPN034156_02460 ]
  • symbol: CrcB
  • description: fluoride efflux transporter CrcB
  • length: 109
  • theoretical pI: 8.77553
  • theoretical MW: 12036.3
  • GRAVY: 0.925688

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function General protein CrcB (TIGR00494; HMM-score: 70.2)
    and 2 more
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, mannose/fructose/sorbose family, IID component (TIGR00828; HMM-score: 14)
    Signal transduction Signal transduction PTS PTS system, mannose/fructose/sorbose family, IID component (TIGR00828; HMM-score: 14)
  • TheSEED: see SPN034156_02460
  • PFAM:
    DMT (CL0184) CRCB; CrcB-like protein, Camphor Resistance (CrcB) (PF02537; HMM-score: 77.6)
    and 5 more
    no clan defined YLATT; YEATS-Like-Associating Three TM (PF20303; HMM-score: 17.1)
    MviN_MATE (CL0222) Polysacc_synt_3; Polysaccharide biosynthesis protein (PF13440; HMM-score: 16.3)
    no clan defined Voltage_CLC; Voltage gated chloride channel (PF00654; HMM-score: 12.6)
    DUF4203; Domain of unknown function (DUF4203) (PF13886; HMM-score: 12.3)
    Ferritin (CL0044) DUF3231; Protein of unknown function (DUF3231) (PF11553; HMM-score: 11.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0001
    • Cytoplasmic Membrane Score: 0.9996
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0003
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.018602
    • TAT(Tat/SPI): 0.000445
    • LIPO(Sec/SPII): 0.023267
  • predicted transmembrane helices (TMHMM): 4

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_015511344 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MVIVYLAIACGLGALVRYFFSRYNQASKLPLGTLIANLLGCFLIGVFYNHVESKEVYAILATGFCGGLTTFSTLNDELQRLLSYKKVFYSYLTLTYIGGLVAIFLGILL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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