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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 20-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN034156
  • locus tag: SPN034156_RS01345 [old locus tag: SPN034156_02540 ]
  • pan locus tag?: PNEUPAN002639000
  • symbol: gdhA
  • pan gene symbol?: gdhA
  • synonym:
  • product: NADP-specific glutamate dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN034156_RS01345 [old locus tag: SPN034156_02540 ]
  • symbol: gdhA
  • product: NADP-specific glutamate dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 269692..271038
  • length: 1347
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021006 (269692..271038) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1158 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGACATCTGCTAAAGAATATATCCAAAGCGTGTTTGAAACTGTGAAAGCTCGTAACGGG
    CACGAGGCTGAATTCCTCCAAGCTGTTGAAGAATTTTTCAACACTTTAGAACCTGTATTT
    GAAAAACACCCTGAGTATATCGAAGAAAATATCTTGGCACGTATTACTGAGCCTGAGCGC
    GTGATTTCTTTCCGTGTTCCTTGGGTTGACCGTGATGGAAAAGTTCAAGTAAACCGTGGT
    TACCGTGTTCAATTCAACTCAGCTGTTGGACCATACAAAGGTGGACTTCGTTTCCACCCA
    ACTGTAAACCAAGGGATCTTGAAATTCCTCGGATTTGAACAAATCTTTAAAAATGTCTTG
    ACTGGACTTCCTATCGGTGGAGGTAAAGGTGGATCAGACTTCGATCCTAAAGGTAAAACA
    GATGCTGAAGTGATGCGCTTCTGCCAAAGCTTCATGACTGAATTGCAAAAACACATCGGA
    CCATCACTTGACGTACCTGCTGGTGATATCGGTGTTGGTGGACGTGAGATTGGTTACCTT
    TACGGTCAATACAAACGTCTTAACCAATTTGATGCTGGTGTCTTGACTGGTAAACCTCTT
    GGATTTGGTGGTAGCTTGATTCGTCCAGAAGCAACTGGTTACGGTTTGGTTTACTATACT
    GAAGAAATGCTCAAAGCTAACGGTAACAGCTTTGCTGGTAAGAAAGTCGTTATTTCAGGT
    TCTGGTAACGTTGCTCAATATGCTCTTCAAAAAGCAACTGAACTCGGTGCAACTGTTATT
    TCTGTTTCTGACTCAAATGGTTATGTCATCGATGAAAATGGTATCGACTTCGATCTTTTG
    GTTGATGTTAAAGAAAAACGTCGTGCTCGTTTGACTGAGTATGCAGCTGAAAAAGCAACT
    GCAACCTACCACGAAGGTACTGTATGGAATTACGCTGGAAACTATGACATTGCTCTTCCA
    TGTGCCACTCAAAACGAAATCAACGGTGAAGCAGCTAAACGTTTGGTTGCTCAAGGCGTT
    ATCTGTGTATCTGAAGGTGCCAACATGCCGAGCGACCTTGATGCCATCAAAGTTTACAAA
    GAAAATGGTATCTTATACGGACCTGCAAAAGCTGCCAACGCTGGTGGTGTAGCCGTTTCA
    GCTCTTGAAATGAGCCAAAACAGTCTTCGCCTCTCATGGACTCGTGAAGAAGTTGATGAC
    CGTCTCAAAGACATCATGACAAACATCTTCAACACAGCTAAAACGACTTCAGAAACATAC
    GGTCTTGATAAAGACTACCTTGCAGGAGCTAACATTGCTGCCTTTGAAAATGTAGCAAAC
    GCTATGATTGCCCAAGGTATTGTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1347

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN034156_RS01345 [old locus tag: SPN034156_02540 ]
  • symbol: GdhA
  • description: NADP-specific glutamate dehydrogenase
  • length: 448
  • theoretical pI: 5.02992
  • theoretical MW: 48847.8
  • GRAVY: -0.244196

⊟Function[edit | edit source]

  • reaction:
    EC 1.4.1.4?  ExPASy
    Glutamate dehydrogenase (NADP+) L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH
  • TIGRFAM:
    6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase (TIGR03201; EC 1.1.1.-; HMM-score: 12.2)
  • TheSEED: see SPN034156_02540
  • PFAM:
    NADP_Rossmann (CL0063) ELFV_dehydrog; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase (PF00208; HMM-score: 297.6)
    and 4 more
    AA_dh_N (CL0603) ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain (PF02812; HMM-score: 168.8)
    NADP_Rossmann (CL0063) NAD_binding_7; Putative NAD(P)-binding (PF13241; HMM-score: 19.7)
    no clan defined AglB_L1; Archaeal glycosylation protein B long peripheral domain (PF18079; HMM-score: 14.6)
    NADP_Rossmann (CL0063) 2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 14.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003073
    • TAT(Tat/SPI): 0.000249
    • LIPO(Sec/SPII): 0.000464
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000199536 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTSAKEYIQSVFETVKARNGHEAEFLQAVEEFFNTLEPVFEKHPEYIEENILARITEPERVISFRVPWVDRDGKVQVNRGYRVQFNSAVGPYKGGLRFHPTVNQGILKFLGFEQIFKNVLTGLPIGGGKGGSDFDPKGKTDAEVMRFCQSFMTELQKHIGPSLDVPAGDIGVGGREIGYLYGQYKRLNQFDAGVLTGKPLGFGGSLIRPEATGYGLVYYTEEMLKANGNSFAGKKVVISGSGNVAQYALQKATELGATVISVSDSNGYVIDENGIDFDLLVDVKEKRRARLTEYAAEKATATYHEGTVWNYAGNYDIALPCATQNEINGEAAKRLVAQGVICVSEGANMPSDLDAIKVYKENGILYGPAKAANAGGVAVSALEMSQNSLRLSWTREEVDDRLKDIMTNIFNTAKTTSETYGLDKDYLAGANIAAFENVANAMIAQGIV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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