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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 26-AUG-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN034183
  • locus tag: SPN034183_07340 [new locus tag: SPN034183_RS03925 ]
  • pan locus tag?: PNEUPAN001758000
  • symbol: ezrA
  • pan gene symbol?: ezrA
  • synonym:
  • product: septation ring formation regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN034183_07340 [new locus tag: SPN034183_RS03925 ]
  • symbol: ezrA
  • product: septation ring formation regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 733271..734998
  • length: 1728
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: FQ312043 (733271..734998) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0710 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGTCTAATGGACAACTAATTTATTTAATGGTTGCAATTGCAGTCATTTTAGTTCTGGCT
    TATGTAGTGGCAATCTTTCTACGTAAGCGAAACGAGGGGAGATTAGAGGCGCTAGAAGAA
    AGAAAAGAAGAACTATACAATCTTCCAGTAAATGATGAAGTAGAAGCTGTAAAAAATATG
    CACTTGATTGGACAAAGTCAAGTGGCTTTCCGTGAATGGAATCAAAAATGGGTCGATTTA
    TCTCTCAACTCTTTTGCCGATATTGAAAATAATCTCTTTGAAGCAGAAGGCTATAACCAT
    TCATTTCGTTTTCTCAAGGCCAGTCATCAAATTGACCAAATTGAGAGTCAAATTACTTTG
    ATTGAAGAAGATATTGCGGCAATTCGCAATGCTTTGGCAGACTTAGAGAAGCAAGAATCT
    AAAAATAGTGGTCGTGTTCTTCATGCTTCGGATTTATTTGAGGAACTTCAGCATAGAGTT
    GCTGAAAATTCAGAACAGTATGGTCAAGCCTTGGATGAAATTGAAAAACAATTAGAAAAT
    ATCCAATCTGAATTTTCACAATTTGTAACCTTGAATTCATCGGGTGACCCTGTGGAAGCC
    GCAGTGATTTTGGATAATACAGAAAATCACATTTTGGCCTTAAGTCATATTGTGGATCGT
    GTTCCAGCCTTGGTTACGACGCTTTCTACAGAATTGCCAGATCAATTACAGGATTTGGAA
    GCCGGTTATCGTAAACTAATTGATGCTAATTATCATTTTGTTGAAACGGATATTGAAGCG
    CGTTTCCACTTGCTTTATGAAGCATTCAAGAAAAACCAAGAGAATATTCGTCAGTTGGAA
    TTGGATAATGCCGAATATGAGAATGGACAGGCACAAGAGGAAATCAATGCCTTGTATGAT
    ATTTTTACTCGAGAAATTGCTGCTCAGAAAGTAGTGGAAAATCTACTTGCAACTCTTCCA
    ACTTACCTTCAACATATGAAAGAGAATAATACTTTATTGGGAGAAGATATTGCACGTTTG
    AACAAGACCTATTTACTTCCTGAGACAGCTGCAAGCCATGTTCGTCGTATTCAGACAGAA
    TTAGAGAGTTTTGAGGCAGCTATTGTTGAGGTAACTTCAAATCAAGAAGAACCAACCCAA
    GCTTATTCAGTTCTTGAAGAAAATCTTGAGGATTTACAAACTCAACTAAAAGATATTGAA
    GATGAGCAAATTTCAGTTAGTGAGCGCCTGACACAAATTGAGAAAGATGATATTAATGCA
    CGTCAAAAGGCCAATGTTTATGTCAATCGTCTCCATACTATCAAGCGATACATGGAAAAA
    CGCAATCTGCCAGGTATTCCACAAACTTTCTTGAAGTTATTCTTTACGGCAAGCAATAAT
    ACCGAGGATTTAATGGTTGAGTTAGAACAAAAAATGATTAACATTGAATCTGTTACCCGA
    GTTCTTGAAATTGCAACGAATGATATGGAAGCTTTAGAAACGGAAACTTATAATATTGTA
    CAATATGCAACTTTGACAGAGCAACTCTTGCAATATTCTAACCGCTATCGCTCATTTGAT
    GAACGCATTCAAGAAGCATTTAACGAAGCTTTAGATATTTTTGAAAAAGAATTTGATTAT
    CACGCTTCATTTGACAAGATTTCTCAAGCATTGGAAGTGGCAGAGCCTGGTGTAACCAAT
    CGCTTTGTTACCTCATATGAGAAAACACGTGAAACGATTCGTTTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1728

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN034183_07340 [new locus tag: SPN034183_RS03925 ]
  • symbol: EzrA
  • description: septation ring formation regulator
  • length: 575
  • theoretical pI: 4.28833
  • theoretical MW: 66493.8
  • GRAVY: -0.445565

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 22.2)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 22.2)
    and 9 more
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02169; HMM-score: 16.2)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02169; HMM-score: 16.2)
    WXG100 family type VII secretion target (TIGR03930; HMM-score: 11.5)
    Metabolism Energy metabolism Other tetrahydromethanopterin S-methyltransferase, subunit G (TIGR01149; EC 2.1.1.86; HMM-score: 9.5)
    helix-rich protein (TIGR04523; HMM-score: 8.2)
    Cellular processes Cellular processes Adaptations to atypical conditions phage shock protein C (TIGR02978; HMM-score: 7.9)
    SH3 domain protein (TIGR04211; HMM-score: 6.7)
    Cellular processes Cellular processes Sporulation and germination stage III sporulation protein AB (TIGR02833; HMM-score: 5.7)
    two transmembrane protein (TIGR04527; HMM-score: 5.2)
  • TheSEED  :
    • Septation ring formation regulator EzrA
  • PFAM:
    no clan defined EzrA; Septation ring formation regulator, EzrA (PF06160; HMM-score: 594.9)
    and 16 more
    SNARE-fusion (CL0445) Syntaxin; Syntaxin (PF00804; HMM-score: 21.1)
    Prefoldin (CL0200) Prefoldin_2; Prefoldin subunit (PF01920; HMM-score: 19.8)
    Pec_lyase-like (CL0268) FapA; Flagellar Assembly Protein A beta solenoid domain (PF03961; HMM-score: 15)
    no clan defined ATG16; Autophagy protein 16 (ATG16) (PF08614; HMM-score: 14.6)
    DUF5304; Family of unknown function (DUF5304) (PF17230; HMM-score: 13.8)
    Tropomyosin-lke (CL0452) Tropomyosin; Tropomyosin (PF00261; HMM-score: 13.6)
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels (PF16526; HMM-score: 13.2)
    EsxAB (CL0352) WXG100; Proteins of 100 residues with WXG (PF06013; HMM-score: 12.8)
    no clan defined DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1) (PF05454; HMM-score: 12)
    Rx_N; Rx N-terminal domain (PF18052; HMM-score: 10.2)
    TPD52; Tumour protein D52 family (PF04201; HMM-score: 9.4)
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region (PF04871; HMM-score: 8.7)
    MtrG; Tetrahydromethanopterin S-methyltransferase, subunit G (PF04210; HMM-score: 8.1)
    ISG65-75; Invariant surface glycoprotein (PF11727; HMM-score: 6.3)
    TMPIT; TMPIT-like protein (PF07851; HMM-score: 5.8)
    Crescentin; Crescentin protein (PF19220; HMM-score: 5.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.94
    • Cytoplasmic Membrane Score: 2.06
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0001
    • Cytoplasmic Membrane Score: 0.9985
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0013
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.028627
    • TAT(Tat/SPI): 0.000758
    • LIPO(Sec/SPII): 0.005428
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CCP32444 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEELYNLPVNDEVEAVKNMHLIGQSQVAFREWNQKWVDLSLNSFADIENNLFEAEGYNHSFRFLKASHQIDQIESQITLIEEDIAAIRNALADLEKQESKNSGRVLHASDLFEELQHRVAENSEQYGQALDEIEKQLENIQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIVDRVPALVTTLSTELPDQLQDLEAGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENIRQLELDNAEYENGQAQEEINALYDIFTREIAAQKVVENLLATLPTYLQHMKENNTLLGEDIARLNKTYLLPETAASHVRRIQTELESFEAAIVEVTSNQEEPTQAYSVLEENLEDLQTQLKDIEDEQISVSERLTQIEKDDINARQKANVYVNRLHTIKRYMEKRNLPGIPQTFLKLFFTASNNTEDLMVELEQKMINIESVTRVLEIATNDMEALETETYNIVQYATLTEQLLQYSNRYRSFDERIQEAFNEALDIFEKEFDYHASFDKISQALEVAEPGVTNRFVTSYEKTRETIRF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Aurore Fleurie, Sylvie Manuse, Chao Zhao, Nathalie Campo, Caroline Cluzel, Jean-Pierre Lavergne, Céline Freton, Christophe Combet, Sébastien Guiral, Boumediene Soufi, Boris Macek, Erkin Kuru, Michael S VanNieuwenhze, Yves V Brun, Anne-Marie Di Guilmi, Jean-Pierre Claverys, Anne Galinier, Christophe Grangeasse
Interplay of the serine/threonine-kinase StkP and the paralogs DivIVA and GpsB in pneumococcal cell elongation and division.
PLoS Genet: 2014, 10(4);e1004275
[PubMed:24722178] [WorldCat.org] [DOI] (I e)

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