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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN034183
  • locus tag: SPN034183_RS04755 [old locus tag: SPN034183_08720 ]
  • pan locus tag?: PNEUPAN001999000
  • symbol: SPN034183_RS04755
  • pan gene symbol?: pmrA
  • synonym:
  • product: multidrug efflux MFS transporter PmrA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN034183_RS04755 [old locus tag: SPN034183_08720 ]
  • symbol: SPN034183_RS04755
  • product: multidrug efflux MFS transporter PmrA
  • replicon: chromosome
  • strand: +
  • coordinates: 884117..885232
  • length: 1116
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021028 (884117..885232) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0860 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATGACAGAGATTAACTGGAAGGATAATCTGCGCATTGCCTGGTTTGGTAATTTTCTGACA
    GGAGCCAGTATTTCTTTGGTTGTACCCTTTATGCCCATCTTCGTGGAAAATCTAGGTGTA
    GGGAGTGAGCAAGTCGCTTTTTATGCAGGCTTAGCAATTTCTGTCTCTGCTATTTCCGCG
    GCGCTCTTTTCTCCTATTTGGGGTATTCTTGCTGACAAATACGGCCGAAAACCCATGATG
    ATTCGGGCAGGTCTTGCTATGACTATCACTATGGGAGGCTTGGCCTTTGTCCCAAATATC
    TATTGGTTAATCTTTCTTCGTTTACTAAACGGTGTATTTGCAGGTTTTGTTCCTAATGCA
    ACGGCACTGATAGCCAGTCAGGTTCCAAAGGAGAAATCAGGCTCTGCCTTAGGTACTTTG
    TCTACAGGCGTAGTTGCAGGTACTCTAACTGGTCCCTTTATTGGTGGCTTTATCAAGGAA
    GATTTTCAACCAGTAGCCAAGGAAAAGGCTATTCCAACAAAGGAATTATTTACCTCGGTT
    AAATATCCCTATCTTTTGCTCAATCTCTTTTTAACCAGTTTTGTCATCCAATTTTCAGCT
    CAATCGATTGGCCCTATTTTGGCTCTTTATGTACGCGACTTAGGGCAGACAGAGAATCTT
    CTTTTTGTCTCTGGTTTGATTGTGTCCAGTATGGGCTTTTCCAGCATGATGAGTGCAGGA
    GTCATGGGCAAGCTAGGTGACAAGGTGGGCAATCATCGTCTCTTGGTTGTCGCCCAGTTT
    TATTCAGTCATCATCTATCTCCTCTGTGCCAATGCCTCTAGCCCCCTTCAACTAGGACTC
    TATCGTTTCCTCTTTGGATTGGGAACCGGTGCCTTGATTCCCGGGGTTAATGCCCTACTC
    AGCAAAATGACTCCCAAAGCCGGCATTTCGAGGGTCTTTGCCTTCAATCAGGTATTCTTT
    TATCTGGGAGGTGTTGTTGGTCCCATGGCAGGTTCTGCAGTAGCAGGTCAATTTGGCTAC
    CATGCTGTCTTTTATGCGACGAGCCTTTGTGTTGCCTTTAGTTGTCTCTTTAACCTGATT
    CAATTTCGAACATTATTAAAAGTAAAGGAAATCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1116

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN034183_RS04755 [old locus tag: SPN034183_08720 ]
  • symbol: SPN034183_RS04755
  • description: multidrug efflux MFS transporter PmrA
  • length: 371
  • theoretical pI: 9.96492
  • theoretical MW: 39769.9
  • GRAVY: 0.739623

⊟Function[edit | edit source]

  • TIGRFAM:
    multidrug resistance protein (TIGR00880; HMM-score: 114.4)
    and 14 more
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids MFS transporter, aromatic acid:H+ symporter (AAHS) family (TIGR00895; HMM-score: 91.5)
    Cellular processes Cellular processes Toxin production and resistance drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family (TIGR00711; HMM-score: 79.4)
    Metabolism Transport and binding proteins Other drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family (TIGR00711; HMM-score: 79.4)
    drug resistance transporter, Bcr/CflA subfamily (TIGR00710; HMM-score: 60.9)
    Metabolism Transport and binding proteins Cations and iron carrying compounds H+ Antiporter protein (TIGR00900; HMM-score: 52.4)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids phosphoglycerate transporter family protein (TIGR00881; HMM-score: 48.9)
    Metabolism Transport and binding proteins Anions Na(+)-dependent inorganic phosphate cotransporter (TIGR00894; HMM-score: 43.6)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cation transport protein (TIGR00898; HMM-score: 43.6)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-galactonate transporter (TIGR00893; HMM-score: 39)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids MFS transporter, sialate:H+ symporter (SHS) family (TIGR00891; HMM-score: 30.2)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids sugar efflux transporter (TIGR00899; HMM-score: 29.3)
    Metabolism Transport and binding proteins Unknown substrate MFS transporter, metabolite:H+ symporter (MHS) family protein (TIGR00883; HMM-score: 27.7)
    synaptic vesicle protein SV2 (TIGR01299; HMM-score: 16.1)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids oxalate/formate antiporter family transporter (TIGR00890; HMM-score: 15.2)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    MFS (CL0015) MFS_1; Major Facilitator Superfamily (PF07690; HMM-score: 160.7)
    and 4 more
    Sugar_tr; Sugar (and other) transporter (PF00083; HMM-score: 57.5)
    MFS_1_like; MFS_1 like family (PF12832; HMM-score: 37)
    MFS_3; Transmembrane secretion effector (PF05977; HMM-score: 30.2)
    Glycine-zipper (CL0500) Rick_17kDa_Anti; Glycine zipper 2TM domain (PF05433; HMM-score: 10)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 10
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.02459
    • TAT(Tat/SPI): 0.000794
    • LIPO(Sec/SPII): 0.004159
  • predicted transmembrane helices (TMHMM): 10

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000136130 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTEINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSEQVAFYAGLAISVSAISAALFSPIWGILADKYGRKPMMIRAGLAMTITMGGLAFVPNIYWLIFLRLLNGVFAGFVPNATALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIKEDFQPVAKEKAIPTKELFTSVKYPYLLLNLFLTSFVIQFSAQSIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDKVGNHRLLVVAQFYSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPKAGISRVFAFNQVFFYLGGVVGPMAGSAVAGQFGYHAVFYATSLCVAFSCLFNLIQFRTLLKVKEI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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