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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN034183
  • locus tag: SPN034183_RS06125 [old locus tag: SPN034183_11320 ]
  • pan locus tag?: PNEUPAN002553000
  • symbol: SPN034183_RS06125
  • pan gene symbol?: licC
  • synonym:
  • product: NTP transferase domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN034183_RS06125 [old locus tag: SPN034183_11320 ]
  • symbol: SPN034183_RS06125
  • product: NTP transferase domain-containing protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1161588..1162277
  • length: 690
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_021028 (1161588..1162277) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1123 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    GTGAAAGCCATTATCTTAGCAGCGGGATTGGGAACTCGCTTGCGTCCTATGACTGAAAAT
    ACCCCTAAAGCCTTGGTTCAGGTTAATCAAAAACCTTTGATTGAATACCAAATTGAGTTT
    CTCAAAGAAAAAGGAATCAATGACATCATCATCATCGTTGGTTATCTTAAAGAACAATTC
    GATTATTTAAAAGAAAAATACGGTGTTCGCCTCGTTTTCAATGATAAATACGCTGACTAC
    AATAACTTTTACTCTCTCTATCTTGTAAAAGAAGAATTGGCCAACAGCTATGTTATTGAT
    GCTGACAATTATCTCTTTAAAAATATGTTCCGCAATGATTTGACACGTTCGACTTATTTT
    AGTGTTTATCGTGAAGATTGTACCAACGAATGGTTCTTGGTCTATGGAGATGACTACAAG
    GTTCAAGACATTATTGTTGATAGCAAGGCAGGTCGCATCCTTAGTGGTGTATCCTTCTGG
    GATGCTCCAACTGCAGAAAAGATTGTCAGCTTTATCGACAAGGCTTATGCAAGTGGTGAA
    TTTGTTGATCTCTACTGGGACAATATGGTTAAGGATAATATCAAAGAGCTAGATGTCTAT
    GTTGAAGAATTAGAAGGCAATAGCATTTATGAGATCGATAGTGTCCAAGACTATCGTAAA
    TTAGAAGAAATTCTTAAAAACGAAAATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    690

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN034183_RS06125 [old locus tag: SPN034183_11320 ]
  • symbol: SPN034183_RS06125
  • description: NTP transferase domain-containing protein
  • length: 229
  • theoretical pI: 4.32935
  • theoretical MW: 26875.3
  • GRAVY: -0.328384

⊟Function[edit | edit source]

  • TIGRFAM:
    UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR03992; EC 2.3.1.157,2.7.7.23; HMM-score: 75.7)
    glucose-1-phosphate thymidylyltransferase (TIGR01208; EC 2.7.7.24; HMM-score: 61.9)
    and 13 more
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UTP--glucose-1-phosphate uridylyltransferase (TIGR01099; EC 2.7.7.9; HMM-score: 50)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides glucose-1-phosphate cytidylyltransferase (TIGR02623; EC 2.7.7.33; HMM-score: 38.7)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides glucose-1-phosphate thymidylyltransferase (TIGR01207; EC 2.7.7.24; HMM-score: 37.2)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 34.7)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 34.7)
    Metabolism Central intermediary metabolism Amino sugars UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 34.7)
    molybdenum cofactor cytidylyltransferase (TIGR03310; EC 2.7.7.76; HMM-score: 29.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (TIGR00453; EC 2.7.7.60; HMM-score: 28.7)
    Signal transduction Regulatory functions Protein interactions regulatory protein GalF (TIGR01105; HMM-score: 25.8)
    Hypothetical proteins Conserved TIGR00454 family protein (TIGR00454; HMM-score: 25.3)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides glucose-1-phosphate adenylyltransferase (TIGR02091; EC 2.7.7.27; HMM-score: 21.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdenum cofactor guanylyltransferase (TIGR02665; EC 2.7.7.77; HMM-score: 16.9)
    methylmalonyl-CoA mutase C-terminal domain (TIGR00640; HMM-score: 12.1)
  • TheSEED: see SPN034183_11320
  • PFAM:
    GT-A (CL0110) NTP_transferase; Nucleotidyl transferase (PF00483; HMM-score: 48)
    NTP_transf_3; MobA-like NTP transferase domain (PF12804; HMM-score: 47.1)
    and 2 more
    IspD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (PF01128; HMM-score: 25)
    DUF6564; Domain of unknown function (DUF6564) (PF20202; HMM-score: 20.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.024463
    • TAT(Tat/SPI): 0.000365
    • LIPO(Sec/SPII): 0.005147
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000643970 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKAIILAAGLGTRLRPMTENTPKALVQVNQKPLIEYQIEFLKEKGINDIIIIVGYLKEQFDYLKEKYGVRLVFNDKYADYNNFYSLYLVKEELANSYVIDADNYLFKNMFRNDLTRSTYFSVYREDCTNEWFLVYGDDYKVQDIIVDSKAGRILSGVSFWDAPTAEKIVSFIDKAYASGEFVDLYWDNMVKDNIKELDVYVEELEGNSIYEIDSVQDYRKLEEILKNEN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

C O Rock, R J Heath, H W Park, S Jackowski
The licC gene of Streptococcus pneumoniae encodes a CTP:phosphocholine cytidylyltransferase.
J Bacteriol: 2001, 183(16);4927-31
[PubMed:11466299] [WorldCat.org] [DOI] (P p)

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