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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN034183
  • locus tag: SPN034183_RS06965 [old locus tag: SPN034183_12890 ]
  • pan locus tag?: PNEUPAN002751000
  • symbol: pdxT
  • pan gene symbol?: pdxT
  • synonym:
  • product: pyridoxal 5'-phosphate synthase glutaminase subunit PdxT

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN034183_RS06965 [old locus tag: SPN034183_12890 ]
  • symbol: pdxT
  • product: pyridoxal 5'-phosphate synthase glutaminase subunit PdxT
  • replicon: chromosome
  • strand: -
  • coordinates: 1306771..1307352
  • length: 582
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021028 (1306771..1307352) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1296 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGAAAATCGGAATATTGGCCTTGCAAGGGGCCTTTGCAGAACATGCAAAAGTGCTAGAT
    CAATTAGGTGTCGAGAGTGTAGAACTCAGAAATCTAGATGATTTTCAGCAAGATCAGAGT
    GACTTGTCGGGTTTGATTTTGCCTGGTGGTGAGTCTACAACCATGGGCAAGCTCTTACGT
    GACCAGAACATGCTACTTCCCATCCGAGAAGCCATTCTATCTGGCTTACCAGTGTTTGGG
    ACCTGTGCGGGCTTAATTTTGCTGGCTAAGGAAATCACTTCTCAGAAAGAGAGTTATCTA
    GGAACTATGGATATGGTGGTCGAGCGTAATGCTTATGGGCGCCAATTAGGAAGTTTCTAC
    ACGGAAGCAGAATGTAAGGGAGTTGGCAAGATTCCAATGACCTTTATCCGTGGTCCGATT
    ATCAGTAGTGTTGGTGAGGGTGTAGAAATTCTAGCAACAGTGAACAATCAAATTGTTGCA
    GCCCAAGAAAAAAATATGTTGGTAAGTTCTTTTCATCCAGAATTGACTGATGATGTGCGC
    TTGCACCAGTACTTTATCAATATGTGTAAAGAAAAAAGTTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    582

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN034183_RS06965 [old locus tag: SPN034183_12890 ]
  • symbol: PdxT
  • description: pyridoxal 5'-phosphate synthase glutaminase subunit PdxT
  • length: 193
  • theoretical pI: 4.73331
  • theoretical MW: 21120.3
  • GRAVY: 0.0357513

⊟Function[edit | edit source]

  • reaction:
    EC 3.5.1.2?  ExPASy
    Glutaminase L-glutamine + H2O = L-glutamate + NH3
    EC 4.3.3.6?  ExPASy
    Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridoxine pyridoxal 5'-phosphate synthase, glutaminase subunit Pdx2 (TIGR03800; EC 2.6.-.-; HMM-score: 277.6)
    and 6 more
    Metabolism Amino acid biosynthesis Histidine family imidazole glycerol phosphate synthase, glutamine amidotransferase subunit (TIGR01855; EC 2.4.2.-; HMM-score: 23.2)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylformylglycinamidine synthase I (TIGR01737; EC 6.3.5.3; HMM-score: 20.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin cobyrinic acid a,c-diamide synthase (TIGR00379; EC 6.3.1.-; HMM-score: 18.7)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis GMP synthase (glutamine-hydrolyzing), N-terminal domain (TIGR00888; EC 6.3.5.2; HMM-score: 18.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin cobyric acid synthase CobQ (TIGR00313; EC 6.3.5.10; HMM-score: 16.3)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides intracellular protease, PfpI family (TIGR01382; HMM-score: 14)
  • TheSEED: see SPN034183_12890
  • PFAM:
    Glutaminase_I (CL0014) SNO; SNO glutamine amidotransferase family (PF01174; HMM-score: 177.8)
    and 5 more
    GATase_3; CobB/CobQ-like glutamine amidotransferase domain (PF07685; HMM-score: 37.8)
    Peptidase_S51; Peptidase family S51 (PF03575; HMM-score: 31.6)
    GATase; Glutamine amidotransferase class-I (PF00117; HMM-score: 31)
    DJ-1_PfpI; DJ-1/PfpI family (PF01965; HMM-score: 16.2)
    Peptidase_C26; Peptidase C26 (PF07722; HMM-score: 14.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.78
    • Cytoplasmic Membrane Score: 8.16
    • Cellwall Score: 0.06
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9899
    • Cytoplasmic Membrane Score: 0.0003
    • Cell wall & surface Score: 0.0005
    • Extracellular Score: 0.0094
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.03676
    • TAT(Tat/SPI): 0.000214
    • LIPO(Sec/SPII): 0.002018
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000689948 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKIGILALQGAFAEHAKVLDQLGVESVELRNLDDFQQDQSDLSGLILPGGESTTMGKLLRDQNMLLPIREAILSGLPVFGTCAGLILLAKEITSQKESYLGTMDMVVERNAYGRQLGSFYTEAECKGVGKIPMTFIRGPIISSVGEGVEILATVNNQIVAAQEKNMLVSSFHPELTDDVRLHQYFINMCKEKS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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