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serotype 4
D39
serotype 2
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serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
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serotype 6A
70585
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A026
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AP200
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serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
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serotype 1
CGSP14
serotype 14
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Hu15
serotype 19A
Hu17
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serotype 14
JJA
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NU83127
serotype 4
OXC141
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SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
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SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 06-FEB-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F03550 [new locus tag: SPN23F_RS01830 ]
  • pan locus tag?: PNEUPAN001248000
  • symbol: mvaK2
  • pan gene symbol?: mvaK2
  • synonym:
  • product: phosphomevalonate kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F03550 [new locus tag: SPN23F_RS01830 ]
  • symbol: mvaK2
  • product: phosphomevalonate kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 346789..347796
  • length: 1008
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGATTGCTGTTAAAACTTGCGGAAAACTCTATTGGGCAGGTGAATATGCTATTTTAGAG
    CCAGGGCAGTTAGCTTTGATAAAGGATATTCCCATCTATATGAGGGCTGAGATTGCTTTT
    TCTGACAGCTACCGTATCTATTCAGATATGTTTGATTTCGCAGTGGACTTAAGGCCTAAT
    CCTGACTACAGCTTGATTCAAGAAACGATTGCTTTGATGGGAGACTTCCTCGCTGTTCGT
    GGTCAGAATTTAAGACCTTTTTCTCTAGAAATCTGTGGCAAAATGGAACGAGAAGGGAAA
    AAGTTTGGTCTAGGTTCTAGTGGCAGCGTCGTTGTCTTGGTTGTCAAGGCTTTACTGGCT
    CTGTATGATGTTTCTGTTGATCAGGAGCTCTTGTTCAAGCTGACTAGCGCTGTCTTGCTC
    AAGCGAGGAGACAATGGTTCCATGGGCGACCTTGCCTGTATTGTGGCAGAGGATTTGGTT
    CTCTACCAGTCATTTGATCGCCAGAAGGTGGCTGCTTGGTTAGAAGAAGAAAACTTGGCG
    ACAGTTCTGGAGCGTGATTGGGGCTTTTCAATTTCACAAGTGAAACCAACTTTAGAATGT
    GATTTCTTAGTGGGATGGACCAAGGAAGTGGCTGTATCGAGTCACATGGTCCAGCAAATC
    AAGCAAAATATCAATCAAAATTTTTTAAGTTCCTCAAAAGAAACGGTGGTTTCTTTGGTC
    GAAGCCTTGGAACAGGGGAAATCAGAAAAGATTATCGAGCAAGTAGAAGTAGCCAGCAAG
    CTTTTAGAAGGCTTGAGTACAGATATTTACACGCCTTTGCTTAGACAGTTGAAAGAAGCC
    AGTCAAGATTTGCAGGCCGTTGCCAAGAGTAGTGGTGCTGGTGGTGGTGACTGTGGCATC
    GCCCTGAGTTTTGATGCGCAATCAACCAAAACCTTAAAAAATCGTTGGGCCGATCTGGGG
    ATTGAGCTCTTATATCAAGAAAGGATAGGACATGACGACAAATCGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1008

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F03550 [new locus tag: SPN23F_RS01830 ]
  • symbol: MvaK2
  • description: phosphomevalonate kinase
  • length: 335
  • theoretical pI: 4.53168
  • theoretical MW: 37040.2
  • GRAVY: -0.000895522

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.4.2?  ExPASy
    Phosphomevalonate kinase ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate
  • TIGRFAM:
    Metabolism Central intermediary metabolism Other phosphomevalonate kinase (TIGR01220; EC 2.7.4.2; HMM-score: 192.7)
    and 4 more
    Metabolism Central intermediary metabolism Other mevalonate kinase (TIGR00549; EC 2.7.1.36; HMM-score: 53.8)
    Unknown function Enzymes of unknown specificity pyridoxal phosphate enzyme, MJ0158 family (TIGR03576; HMM-score: 11.8)
    Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate kinase (TIGR01920; EC 2.7.1.71; HMM-score: 11.7)
    Metabolism Central intermediary metabolism Other phosphomevalonate kinase (TIGR01219; EC 2.7.4.2; HMM-score: 11.3)
  • TheSEED  :
    • Phosphomevalonate kinase (EC 2.7.4.2)
    Fatty Acids, Lipids, and Isoprenoids Isoprenoids Isoprenoid Biosynthesis  Phosphomevalonate kinase (EC 2.7.4.2)
  • PFAM:
    S5 (CL0329) GHMP_kinases_N; GHMP kinases N terminal domain (PF00288; HMM-score: 36)
    and 3 more
    GHMP_C (CL0677) GHMP_kinases_C; GHMP kinases C terminal (PF08544; HMM-score: 23.9)
    no clan defined Vta1; Vta1 like (PF04652; HMM-score: 14)
    mRNA_stabil; mRNA stabilisation (PF13929; HMM-score: 12.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.78
    • Cytoplasmic Membrane Score: 8.16
    • Cellwall Score: 0.06
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004088
    • TAT(Tat/SPI): 0.000114
    • LIPO(Sec/SPII): 0.000792
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CAR68210 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIAVKTCGKLYWAGEYAILEPGQLALIKDIPIYMRAEIAFSDSYRIYSDMFDFAVDLRPNPDYSLIQETIALMGDFLAVRGQNLRPFSLEICGKMEREGKKFGLGSSGSVVVLVVKALLALYDVSVDQELLFKLTSAVLLKRGDNGSMGDLACIVAEDLVLYQSFDRQKVAAWLEEENLATVLERDWGFSISQVKPTLECDFLVGWTKEVAVSSHMVQQIKQNINQNFLSSSKETVVSLVEALEQGKSEKIIEQVEVASKLLEGLSTDIYTPLLRQLKEASQDLQAVAKSSGAGGGDCGIALSFDAQSTKTLKNRWADLGIELLYQERIGHDDKS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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