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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 11-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F_RS01365 [old locus tags: SPN23F02600 SPN23F_02600 ]
  • pan locus tag?: PNEUPAN001009000
  • symbol: SPN23F_RS01365
  • pan gene symbol?: polC
  • synonym:
  • product: PolC-type DNA polymerase III

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F_RS01365 [old locus tags: SPN23F02600 SPN23F_02600 ]
  • symbol: SPN23F_RS01365
  • product: PolC-type DNA polymerase III
  • replicon: chromosome
  • strand: +
  • coordinates: 246468..250859
  • length: 4392
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    3721
    3781
    3841
    3901
    3961
    4021
    4081
    4141
    4201
    4261
    4321
    4381
    ATGTCAAATAGTTTTGAAATTTTGATGAATCAATTGGGGATGCCTGCTGAAATGAGACAG
    GCTCCTGCTTTAGCACAGGCCGATATTGAGCGAGTTGTGGTTCATAAAATTAGTAAGGTA
    TGGGAGTTTCATTTCGTATTTTCTAATATTTTACCGATTGAAATCTTTTTAGAATTAAAG
    AAGGGTTTGAGGGAAGAATTTTCTAAGACAGGGAATAAAGCTATTTTCGAAATCAAGGTT
    CTGTCTCAAGAATTTTCAAATCAACTCTTACAAGCCTATTATAGAGAGGTTTTTTCTGAA
    GGGCCGTGTGCTAGTCAAGGCTTTAAATCTCTTTATCAGAATTTGCAAGTTCGTGCGGAG
    GACAATCAACTCTTTATTGAAGGCTCAGAGGCGATTGATAAGGAACACTTTAAGAAAAAT
    CATCTGCCTAATTTAGCTAAACAACTTGAAAAATTTGGTTTTCCAGCTTTTAACTGTCAG
    GTCGAGAAGAATGATGTGCTGACCCAAGAGCAGGAAGAGGCCTTTTATGCTGAAAATGAG
    CAGATTGTTCAAGCTGCCAACGAGGAAGCGCTCCGTGCTATGGAGCAACTGGAACAGATG
    GCACCTCCTCCAGCGGAAGAGAAACCAGCCTTTGATTTTCAGGCCAAAAAAGCTGAAGCT
    AAACCAAAGCTGGACAAGGCGGAGATTACTCCTATGATCGAAGTGACGACGGAGGAAAAT
    CGTCTGGTCTTTGAAGGGGTTGTTTTTGATGTGGAGCAAAAAGTGACCAGAACAGGGCGT
    GTTTTGATCAACTTTAAAATGACGGACTACACTTCAAGTTTTTCGATGCAAAAGTGGGTT
    AAGAACGAGGAAGAGGCTCAGAAGTTTGATTTAATCAAGAAAAACTCTTGGCTTCGAGTC
    CGTGGGAATGTGGAGATGAATAACTTCACACGCGATTTGACTATGAATGTGCAGGATGTG
    CAGGAAGTTGTTCACTATGAGCGGAAGGATTTGATGCCAGAAGGTGAGCGCCGGGTTGAG
    TTTCATGCTCATACTAATATGTCGACCATGGATGCTCTACCAGAGGTAGAAGAAATCGTT
    GCAACAGCTGCTAAGTGGGGACACAAGGCGGTTGCCATCACGGACCATGGGAATGTCCAG
    TCCTTCCCACATGGCTATAAGGCGGCTAAGAAAGCGGGAATCCAGCTGATCTATGGTATG
    GAAGCTAATATCGTGGAGGACCGTGTCCCTATCGTCTATAACGAAGTAGAGATGGACTTG
    TTAGAAGCGACCTACGTGGTCTTTGACGTGGAAACGACGGGGCTTTCAGCCATCTATAAT
    GACTTGATTCAGGTTGCGGCTTCTAAGATGTACAAGGGGAATGTTATTGCCGAATTTGAT
    GAATTTATCAATCCTGGGCATCCCTTGTCAGCTTTTACTACTGAGTTGACCGGAATTACA
    GATGATCATGTAAAAAATGCTAAACCACTAGAACAAGTTTTGCAAGAATTCCAAGAATTC
    TGCAAGGATACTGTCCTAGTCGCCCACAATGCGACCTTTGACGTTGGCTTTATGAATGCC
    AATTATGAGCGTCATGGTCTGCCAAAGATTAGTCAGCCAGTTATTGATACACTTGAGTTT
    GCTAGAAATCTCTATCCTGAGTATAAACGTCATGGTTTGGGGCCTTTGACCAAGCGTTTT
    GGTGTGGCCTTAGAACATCACCACATGGCCAACTACGATGCGGAAGCTACAGGTCGCCTG
    CTTTTCATCTTTATCAAAGAGGTGGCAGAAAAACATGGTGTGACCGATCTAGCTAGACTC
    AACATTGATTTGATTAGTCCAGATTCTTATAAAAAAGCTCGCATCAAGCATGCGACCATT
    TATGTCAAGAATCAAGTAGGGCTAAAAAATATCTTTAAGCTGGTTTCCTTGTCTAATACC
    AAGTACTTTGAAGGAGTGCCACGGATTCCAAGAACGGTTCTAGATGCTCATCGGGAAGGT
    TTGATTTTAGGTTCAGCTTGCTCTGAAGGTGAAGTTTTTGATGCAGTCGTTTCCCAGGGC
    GTGGATGCGGCGGTTGAGGTGGCCAAGTATTATGACTTTATCGAGGTCATGCCCCCAGCT
    ATCTATGCTCCCTTGATTGCCAAGGAGCAGGTCAAGGATATGGAGGAACTCCAGACCATT
    ATCAAGAGTTTGATAGAAGTTGGAGACCGTCTTGGTAAACCCGTTCTGGCTACCGGAAAT
    GTTCACTATATCGAACCGGAAGAAGAGATTTACCGTGAAATTATCGTCCGTAGTTTGGGA
    CAGGGGGCGATGATTAACCGAACTATTGGTCATGGCGAACATGCCCAACCCGCTCCTCTT
    CCAAAAGCTCATTTTAGAACGACTAATGAAATGTTGGATGAATTTGCCTTCTTGGGAGAG
    GAATTAGCTCGCAAATTGGTTATTGAAAATACCAATGCCTTGGCAGATATCTTTGAACCT
    GTTGAGGTAGTTAAGGGTGACTTGTATACGCCTTTCATCGACAAGGCGGAAGAAACGGTC
    GCTGAATTGACCTATAAGAAGGCCTTTGAGATTTATGGTAATCCGCTGCCAGATATCGTT
    GATTTGCGGATTGAAAAAGAACTAACCTCTATTCTGGGGAATGGATTTGCTGTGATTTAT
    CTGGCCTCGCAGATGCTGGTTCAACGTTCCAATGAACGGGGCTACTTGGTTGGTTCTCGT
    GGGTCTGTCGGATCTAGTTTCGTTGCGACCATGATTGGGATTACAGAGGTCAATCCTCTC
    TCTCCTCACTATGTCTGTGGTCAGTGTCAGTACAGCGAGTTTATCACCGATGGTTCTTAT
    GGTTCAGGTTTTGATATGCCCAATAAGGACTGTCCAAACTGTGGTCATAAACTCAGCAAA
    AACGGACAGGATATTCCTTTCGAGACCTTCCTTGGTTTTGATGGGGATAAGGTTCCTGAT
    ATTGACTTGAACTTCTCGGGAGAAGATCAGCCTAGCGCCCACTTGGATGTGCGTGATATC
    TTTGGTGAAGAATATGCCTTCCGTGCAGGAACGGTTGGTACGGTAGCTGCTAAAACTGCT
    TATGGCTTTGTAAAGGGCTATGAGCGAGATTATGGCAAGTTTTATCGTGATGCAGAGGTG
    GAACGTCTTGCTCAAGGTGCGGCTGGTGTCAAGCGGACAACGGGACAACACCCGGGGGGA
    ATCGTTGTTATTCCTAACTACATGGATGTTTACGATTTTACGCCTGTCCAGTATCCAGCA
    GATGACGTGACGGCTGAATGGCAGACCACTCACTTTAACTTTCACGATATCGATGAGAAC
    GTTCTCAAACTCGATGTGCTGGGGCATGATGATCCGACCATGATTCGGAAACTGCAGGAT
    TTGTCTGGGATTGATCCTAATGAAATCCCTATGGATGATGAAGGTGTGATGGCTCTCTTT
    TCTGGGACTGACGTGCTTGGGGTAACACCTGAACAAATCGGAACGCCAACGGGCATGCTG
    GGAATTCCAGAGTTTGGAACCAACTTTGTACGTGGGATGGTAGATGAGACGCATCCGACG
    ACCTTTGCGGAGTTGCTTCAGCTGTCTGGATTATCCCATGGTACCGATGTCTGGTTGGGA
    AATGCTCAGGATTTAATCAAGCAAGGGATTGCGGATCTATCGACCGTTATCGGTTGTCGG
    GACGACATCATGGTTTACCTCATGCATGCTGGTCTAGAACCTAAGATGGCCTTTACTATC
    ATGGAACGGGTACGTAAGGGCTTGTGGTTGAAGATTTCAGAAGAGGAACGAAATGGCTAT
    ATCGAAGCCATGAAAGCTAACAAGGTGCCAGAGTGGTATATCGAATCCTGTGGGAAAATC
    AAGTATATGTTCCCTAAAGCCCATGCGGCAGCCTACGTTATGATGGCCTTGCGTGTGGCC
    TACTTCAAGGTTCACCATCCCATTTATTACTACTGTGCTTACTTCTCAATCCGCGCCAAG
    GCTTTTGATATCAAGACCATGGGAGCAGGCTTGGATGCTATTAAGCGTAGAATGGAAGAA
    ATCTCTGAAAAACGGAAGAACAATGAAGCCTCTAATGTGGAAATTGACCTCTATACAACC
    CTTGAGATTGTCAATGAAATGTGGGAACGCGGTTTCAAGTTTGGGAAGTTAGACCTCTAC
    CGTAGTGATGCGACTGAATTCATCATTGACGGAGATACGCTGATTCCACCATTTGTAGCA
    ATGGATGGTCTGGGAGAGAACGTTGCCAAGCAATTGGTGCGAGCGCGAGAAGAGGGAGAA
    TTTCTCTCTAAAACAGAACTACGCAAGCGTGGTGGACTCTCATCAACCTTGGTTGAAAAG
    ATGGATGAAATGGGGATTCTGGGCAATATGCCAGAGGACAATCAGTTGAGTTTGTTTGAT
    GAGTTGTTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3540
    3600
    3660
    3720
    3780
    3840
    3900
    3960
    4020
    4080
    4140
    4200
    4260
    4320
    4380
    4392

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F_RS01365 [old locus tags: SPN23F02600 SPN23F_02600 ]
  • symbol: SPN23F_RS01365
  • description: PolC-type DNA polymerase III
  • length: 1463
  • theoretical pI: 4.77011
  • theoretical MW: 164831
  • GRAVY: -0.274709

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.7.7?  ExPASy
    DNA-directed DNA polymerase Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, alpha subunit, Gram-positive type (TIGR01405; EC 2.7.7.7; HMM-score: 1974.8)
    and 5 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, alpha subunit (TIGR00594; EC 2.7.7.7; HMM-score: 189.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair putative DnaQ family exonuclease/DinG family helicase (TIGR01407; HMM-score: 139)
    Genetic information processing DNA metabolism Degradation of DNA exonuclease, DNA polymerase III, epsilon subunit family (TIGR00573; EC 2.7.7.7; HMM-score: 129.1)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, epsilon subunit (TIGR01406; EC 2.7.7.7; HMM-score: 87.3)
    Genetic information processing Transcription RNA processing ribonuclease T (TIGR01298; EC 3.1.13.-; HMM-score: 29.1)
  • TheSEED: see SPN23F02600
  • PFAM:
    NTP_transf (CL0260) DNA_pol3_alpha; Bacterial DNA polymerase III alpha NTPase domain (PF07733; HMM-score: 192.4)
    and 12 more
    Amidohydrolase (CL0034) PHP; PHP domain (PF02811; HMM-score: 146.4)
    RNase_H (CL0219) RNase_T; Exonuclease (PF00929; HMM-score: 119.8)
    no clan defined DNA_pol3_finger; Bacterial DNA polymerase III alpha subunit finger domain (PF17657; HMM-score: 95.2)
    DnaA_N (CL0494) DNA_pol3_a_NII; DNA polymerase III polC-type N-terminus II (PF11490; HMM-score: 78)
    no clan defined DNA_pol3_a_NI; DNA polymerase III polC-type N-terminus I (PF14480; HMM-score: 62.9)
    HHH (CL0198) HHH_6; Helix-hairpin-helix motif (PF14579; HMM-score: 26.9)
    RNase_H (CL0219) Rv2179c-like; 3'-5' exoribonuclease Rv2179c-like domain (PF16473; HMM-score: 20.7)
    HHH (CL0198) HHH_3; Helix-hairpin-helix motif (PF12836; HMM-score: 19.5)
    OB (CL0021) tRNA_anti-codon; OB-fold nucleic acid binding domain (PF01336; HMM-score: 19.4)
    RNase_H (CL0219) RNase_H_2; RNase_H superfamily (PF13482; HMM-score: 17.3)
    DNA_pol_A_exo1; 3'-5' exonuclease (PF01612; HMM-score: 15.9)
    Zn_Beta_Ribbon (CL0167) Zn-ribbon_8; Zinc ribbon domain (PF09723; HMM-score: 11.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.989
    • Cytoplasmic Membrane Score: 0.0011
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0097
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00528
    • TAT(Tat/SPI): 0.000754
    • LIPO(Sec/SPII): 0.000525
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000071374 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSNSFEILMNQLGMPAEMRQAPALAQADIERVVVHKISKVWEFHFVFSNILPIEIFLELKKGLREEFSKTGNKAIFEIKVLSQEFSNQLLQAYYREVFSEGPCASQGFKSLYQNLQVRAEDNQLFIEGSEAIDKEHFKKNHLPNLAKQLEKFGFPAFNCQVEKNDVLTQEQEEAFYAENEQIVQAANEEALRAMEQLEQMAPPPAEEKPAFDFQAKKAEAKPKLDKAEITPMIEVTTEENRLVFEGVVFDVEQKVTRTGRVLINFKMTDYTSSFSMQKWVKNEEEAQKFDLIKKNSWLRVRGNVEMNNFTRDLTMNVQDVQEVVHYERKDLMPEGERRVEFHAHTNMSTMDALPEVEEIVATAAKWGHKAVAITDHGNVQSFPHGYKAAKKAGIQLIYGMEANIVEDRVPIVYNEVEMDLLEATYVVFDVETTGLSAIYNDLIQVAASKMYKGNVIAEFDEFINPGHPLSAFTTELTGITDDHVKNAKPLEQVLQEFQEFCKDTVLVAHNATFDVGFMNANYERHGLPKISQPVIDTLEFARNLYPEYKRHGLGPLTKRFGVALEHHHMANYDAEATGRLLFIFIKEVAEKHGVTDLARLNIDLISPDSYKKARIKHATIYVKNQVGLKNIFKLVSLSNTKYFEGVPRIPRTVLDAHREGLILGSACSEGEVFDAVVSQGVDAAVEVAKYYDFIEVMPPAIYAPLIAKEQVKDMEELQTIIKSLIEVGDRLGKPVLATGNVHYIEPEEEIYREIIVRSLGQGAMINRTIGHGEHAQPAPLPKAHFRTTNEMLDEFAFLGEELARKLVIENTNALADIFEPVEVVKGDLYTPFIDKAEETVAELTYKKAFEIYGNPLPDIVDLRIEKELTSILGNGFAVIYLASQMLVQRSNERGYLVGSRGSVGSSFVATMIGITEVNPLSPHYVCGQCQYSEFITDGSYGSGFDMPNKDCPNCGHKLSKNGQDIPFETFLGFDGDKVPDIDLNFSGEDQPSAHLDVRDIFGEEYAFRAGTVGTVAAKTAYGFVKGYERDYGKFYRDAEVERLAQGAAGVKRTTGQHPGGIVVIPNYMDVYDFTPVQYPADDVTAEWQTTHFNFHDIDENVLKLDVLGHDDPTMIRKLQDLSGIDPNEIPMDDEGVMALFSGTDVLGVTPEQIGTPTGMLGIPEFGTNFVRGMVDETHPTTFAELLQLSGLSHGTDVWLGNAQDLIKQGIADLSTVIGCRDDIMVYLMHAGLEPKMAFTIMERVRKGLWLKISEEERNGYIEAMKANKVPEWYIESCGKIKYMFPKAHAAAYVMMALRVAYFKVHHPIYYYCAYFSIRAKAFDIKTMGAGLDAIKRRMEEISEKRKNNEASNVEIDLYTTLEIVNEMWERGFKFGKLDLYRSDATEFIIDGDTLIPPFVAMDGLGENVAKQLVRAREEGEFLSKTELRKRGGLSSTLVEKMDEMGILGNMPEDNQLSLFDELF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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