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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
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serotype 6A
70585
serotype 5
A026
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A66
serotype 3
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ATCC 49619
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ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
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HU-OH
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Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
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R6
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SP49
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SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F_RS02140 [old locus tags: SPN23F04190 SPN23F_04190 ]
  • pan locus tag?: PNEUPAN001320000
  • symbol: ilvC
  • pan gene symbol?: ilvC
  • synonym:
  • product: ketol-acid reductoisomerase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F_RS02140 [old locus tags: SPN23F04190 SPN23F_04190 ]
  • symbol: ilvC
  • product: ketol-acid reductoisomerase
  • replicon: chromosome
  • strand: +
  • coordinates: 401992..403014
  • length: 1023
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGACAGTTCAAATGGAATATGAAAAAGATGTTAAAGTAGCAGCACTTGACGGTAAAAAA
    ATCGCCGTTATCGGTTATGGTTCACAAGGGCATGCGCATGCTCAAAACTTGCGTGATTCA
    GGTCGTGACGTTATTATCGGTGTACGTCCAGGTAAATCTTTTGATAAAGCAAAAGAAGAT
    GGATTTGATACTTACACAGTAGCAGAAGCTACTAAGTTGGCTGATGTTATCATGATCTTG
    GCGCCAGACGAAATTCAACAAGAATTGTACGAAGCAGAAATCGCTCCAAACTTGGAAGCT
    GGAAACGCAGTTGGATTTGCCCATGGTTTCAACATCCACTTTGAATTTATCAAAGTTCCT
    GCGGATGTAGATGTCTTCATGTGTGCTCCTAAAGGACCAGGACACTTGGTACGTCGTACT
    TACGAAGAAGGATTTGGTGTTCCAGCTCTTTATGCAGTATACCAAGATGCAACAGGAAAT
    GCTAAAAACATTGCTATGGACTGGTGTAAAGGTGTTGGAGCGGCTCGTGTAGGTCTTCTT
    GAAACAACTTACAAAGAAGAAACTGAAGAAGATTTGTTTGGTGAACAAGCTGTACTTTGT
    GGTGGTTTGACTGCCCTTATCGAAGCAGGTTTCGAAGTCTTGACAGAAGCAGGTTACGCT
    CCAGAATTGGCTTACTTTGAAGTTCTTCACGAAATGAAATTGATCGTTGACTTGATCTAC
    GAAGGTGGATTCAAGAAAATGCGTCAATCTATTTCAAACACTGCTGAATACGGTGACTAT
    GTATCAGGTCCACGTGTAATCACTGAACAAGTTAAAGAAAATATGAAGGCTGTCTTGGCA
    GACATCCAAAATGGTAAATTTGCAAATGACTTTGTAAATGACTATAAAGCTGGACGTCCA
    AAATTGACTGCTTACCGTGAACAAGCAGCTAACCTTGAAATTGAAAAAGTTGGTGCAGAA
    TTGCGTAAAGCAATGCCATTCGTTGGTAAAAACGACGATGATGCATTCAAAATCTATAAC
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1023

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F_RS02140 [old locus tags: SPN23F04190 SPN23F_04190 ]
  • symbol: IlvC
  • description: ketol-acid reductoisomerase
  • length: 340
  • theoretical pI: 4.57001
  • theoretical MW: 37350.1
  • GRAVY: -0.222647

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.86?  ExPASy
    Ketol-acid reductoisomerase (NADP+) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Pyruvate family ketol-acid reductoisomerase (TIGR00465; EC 1.1.1.86; HMM-score: 445.3)
    and 6 more
    Metabolism Energy metabolism Amino acids and amines adenosylhomocysteinase (TIGR00936; EC 3.3.1.1; HMM-score: 27.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A 2-dehydropantoate 2-reductase (TIGR00745; EC 1.1.1.-; HMM-score: 16.7)
    2-hydroxy-3-oxopropionate reductase (TIGR01505; EC 1.1.1.60; HMM-score: 14.2)
    Metabolism Energy metabolism Pentose phosphate pathway 6-phosphogluconate dehydrogenase (decarboxylating) (TIGR00872; EC 1.1.1.44; HMM-score: 12.5)
    Cellular processes Cellular processes Sporulation and germination dipicolinic acid synthetase, A subunit (TIGR02853; HMM-score: 12.1)
    Metabolism Energy metabolism TCA cycle succinate-CoA ligase, alpha subunit (TIGR01019; EC 6.2.1.-; HMM-score: 11.9)
  • TheSEED: see SPN23F04190
  • PFAM:
    NADP_Rossmann (CL0063) IlvN; Acetohydroxy acid isomeroreductase, NADPH-binding domain (PF07991; HMM-score: 253.6)
    6PGD_C (CL0106) IlvC; Acetohydroxy acid isomeroreductase, catalytic domain (PF01450; HMM-score: 212)
    and 9 more
    NADP_Rossmann (CL0063) F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 28.3)
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 27.1)
    AdoHcyase_NAD; S-adenosyl-L-homocysteine hydrolase, NAD binding domain (PF00670; HMM-score: 24)
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase (PF03446; HMM-score: 23.8)
    ApbA; Ketopantoate reductase PanE/ApbA (PF02558; HMM-score: 16.3)
    no clan defined DUF1103; Repeat of unknown function (DUF1103) (PF06513; HMM-score: 16.3)
    NADP_Rossmann (CL0063) CoA_binding; CoA binding domain (PF02629; HMM-score: 16.1)
    NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus (PF01210; HMM-score: 15.5)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 12.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.041293
    • TAT(Tat/SPI): 0.002652
    • LIPO(Sec/SPII): 0.003974
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MTVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDVIIGVRPGKSFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGNAVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGNAKNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAGYAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMKAVLADIQNGKFANDFVNDYKAGRPKLTAYREQAANLEIEKVGAELRKAMPFVGKNDDDAFKIYN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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