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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN994038
  • locus tag: SPN994038_RS01780 [old locus tag: SPN994038_03330 ]
  • pan locus tag?: PNEUPAN001122000
  • symbol: SPN994038_RS01780
  • pan gene symbol?: regR
  • synonym:
  • product: LacI family DNA-binding transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN994038_RS01780 [old locus tag: SPN994038_03330 ]
  • symbol: SPN994038_RS01780
  • product: LacI family DNA-binding transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 320018..321019
  • length: 1002
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021026 (320018..321019) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0301 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    TTGGAGAAGAAACTGACCATAAAAGACATTGCGGAAATGGCTCAGACCTCGAAAACAACC
    GTGTCATTTTACCTAAACGGGAAATATGAAAAAATGTCCCAAGAGACACGTGAAAAGATT
    GAAAAAGTTATTCATGAAACAAATTACAAACCGAGCATTGTTGCGCGTAGCTTAAACTCC
    AAACGAACAAAATTAATCGGTGTTTTGATCGGTGATATTACCAACAGTTTCTCAAACCAA
    ATTGTTAAGGGAATTGAGGATATCGCCAGCCAGAATGGCTACCAGGTAATGATAGGAAAT
    AGTAATTACAGCCAAGAGAGTGAGGACCGGTATATTGAAAGCATGCTTCTCTTGGGAGTA
    GACGGCTTTATTATTCAGCCGACCTCTAATTTCCGAAAATATTCTCGTATTATCGATGAG
    AAAAAGAAGAAAATGGTCTTTTTTGATAGTCAGCTCTATGAACACCGGACTAGCTGGGTT
    AAAACCAATAACTATGATGCCGTTTATGACATGACCCAGTCCTGTATCGAAAAAGGTTAT
    GAGCATTTTCTCTTGATTACAGCGGATACGAGTCGTTTGAGTACTCGGATTGAGCGGGCA
    AGTGGTTTTGTGGATGCTTTAACAGATGCTAATATGCGTCACGCCAGTCTAACCATTGAA
    GATAAGCATACGAATTTGGAACAAATTAAAGAATTTTTACAAAAAGAAATCGATCCCGAT
    GAAAAAACTCTGGTATTTATCCCTAACTGTTGGGCCCTACCTCTAGTCTTTACCGTTATC
    AAAGAGTTGAATTATAACTTGCCGCAAGTTGGGTTGATTGGTTTTGACAATACGGAGTGG
    ACTTGCTTTTCTTCTCCAAGTGTTTCGACGCTGGTTCAGCCCTCCTTTGAGGAAGGACAA
    CAGGCTACAAAGATTTTGATTGACCAGATTGAAGGCCGCAATCAAGAAGAAAGGCAACAA
    GTCTTGGATTGTAGTGTGAATTGGAAAGAGTCGACTTTCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1002

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN994038_RS01780 [old locus tag: SPN994038_03330 ]
  • symbol: SPN994038_RS01780
  • description: LacI family DNA-binding transcriptional regulator
  • length: 333
  • theoretical pI: 5.16897
  • theoretical MW: 38333.2
  • GRAVY: -0.473273

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions catabolite control protein A (TIGR01481; HMM-score: 149.3)
    Signal transduction Regulatory functions DNA interactions D-fructose-responsive transcription factor (TIGR02417; HMM-score: 146.3)
    and 2 more
    Signal transduction Regulatory functions DNA interactions trehalose operon repressor (TIGR02405; HMM-score: 110.1)
    Signal transduction Regulatory functions DNA interactions transcriptional repressor BetI (TIGR03384; HMM-score: 15.2)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    HTH (CL0123) LacI; Bacterial regulatory proteins, lacI family (PF00356; HMM-score: 62.3)
    Periplas_BP (CL0144) Peripla_BP_1; Periplasmic binding proteins and sugar binding domain of LacI family (PF00532; HMM-score: 62.1)
    Peripla_BP_4; Periplasmic binding protein domain (PF13407; HMM-score: 58.5)
    Peripla_BP_3; Periplasmic binding protein-like domain (PF13377; HMM-score: 53.6)
    and 5 more
    HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 21.7)
    HTH_19; Helix-turn-helix domain (PF12844; HMM-score: 20.5)
    Terminase_5; Putative ATPase subunit of terminase (gpP-like) (PF06056; HMM-score: 12.4)
    GerE; Bacterial regulatory proteins, luxR family (PF00196; HMM-score: 12)
    HTH_40; Helix-turn-helix domain (PF14493; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by RegR, TF important in Hyaluronate utilization: in TIGR4

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008042
    • TAT(Tat/SPI): 0.000515
    • LIPO(Sec/SPII): 0.002346
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000412453 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEKKLTIKDIAEMAQTSKTTVSFYLNGKYEKMSQETREKIEKVIHETNYKPSIVARSLNSKRTKLIGVLIGDITNSFSNQIVKGIEDIASQNGYQVMIGNSNYSQESEDRYIESMLLLGVDGFIIQPTSNFRKYSRIIDEKKKKMVFFDSQLYEHRTSWVKTNNYDAVYDMTQSCIEKGYEHFLLITADTSRLSTRIERASGFVDALTDANMRHASLTIEDKHTNLEQIKEFLQKEIDPDEKTLVFIPNCWALPLVFTVIKELNYNLPQVGLIGFDNTEWTCFSSPSVSTLVQPSFEEGQQATKILIDQIEGRNQEERQQVLDCSVNWKESTF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Sabine Chapuy-Regaud, A David Ogunniyi, Nicole Diallo, Yvette Huet, Jean-François Desnottes, James C Paton, Sonia Escaich, Marie-Claude Trombe
RegR, a global LacI/GalR family regulator, modulates virulence and competence in Streptococcus pneumoniae.
Infect Immun: 2003, 71(5);2615-25
[PubMed:12704136] [WorldCat.org] [DOI] (P p)

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