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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN994038
  • locus tag: SPN994038_RS02010 [old locus tag: SPN994038_03770 ]
  • pan locus tag?: PNEUPAN001251000
  • symbol: SPN994038_RS02010
  • pan gene symbol?: vraS
  • synonym:
  • product: sensor histidine kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN994038_RS02010 [old locus tag: SPN994038_03770 ]
  • symbol: SPN994038_RS02010
  • product: sensor histidine kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 370619..371614
  • length: 996
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021026 (370619..371614) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0351 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGAAAAAACAAGCCTATGTCATTATTGCTCTCACCTCCTTCCTATTTGTCTTTTTTTTC
    TCCCACAGCTTGCTGGAAATACTTGATTTTGACTGGTCTATCTTTTTGCACGATGTCGAA
    AAAACAGAAAAATTTGTCTTTTTATTGTTGGTTTTCAGCATGTCCATAACCTGTCTCTTA
    GCCCTGTTTTGGCGAGGGATCGAAGAGCTTTCTCTAAGAAAAATGCAGGCTAATCTCAAG
    CGTTTATTGGCAGGGCAAGAAGTGGTTCAGGTTGCAGATCCAGATTTGGATGCCAGTTTC
    AAGTCCTTATCAGGTAAACTTAACCTTTTGACAGAAGCTCTTCAAAAAGCTGAAAATCAT
    AGCCTTGCTCAGGAAGAGGAAATCATCGAGAAAGAACGGAAGCGAATTGCTCGGGATTTG
    CACGATACAGTCAGTCAGGAGTTGTTTGCGGCCCACATGATTTTATCGGGTATCAGTCAG
    CAGGCTTTGAAATTGGATAGAGAAAAGATGCAGATCCAGTTGCAGAGTGTCACAGCTATT
    TTAGAAACTGCCCAGAAGGATTTGCGGGTTTTGCTCTTGCATTTGCGACCAGTTGAACTG
    GAGCAGAAGAGCTTGATAGAAGGGATTCAGATTCTCTTAAAAGAGCTTGAGGACAAGAGT
    GATCTTAGGGTTAGTCTCAAGCAGAATATGACGAAATTGCCTAAGAAAATCGAGGAGCAT
    ATCTTCCGTATCCTGCAAGAGTTGATTAGCAATACGCTCCGCCATGCCCAGGCATCTTGC
    CTAGATGTCTACCTCTATCAGACAGATGTTGAATTGCAACTGAAGGTGGTGGACAATGGG
    ATTGGTTTCCGGTTAGGGAGCTTAGACGACTTGAGTTATGGACTGCGAAATATCAAGGAG
    CGGGTTGAAGATATGGCAGGGACGGTTCAGTTATTAACAGCTCCCAAGCAAGGGCTGGCA
    GTTGATATCCGTATTCCCCTGTTAGATAAGGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    996

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN994038_RS02010 [old locus tag: SPN994038_03770 ]
  • symbol: SPN994038_RS02010
  • description: sensor histidine kinase
  • length: 331
  • theoretical pI: 5.9059
  • theoretical MW: 37933.1
  • GRAVY: 0.0244713

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Signal transduction Two-component systems phosphate regulon sensor kinase PhoR (TIGR02966; EC 2.7.3.-; HMM-score: 18.9)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    His_Kinase_A (CL0025) HisKA_3; Histidine kinase (PF07730; HMM-score: 57.5)
    and 6 more
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 26.7)
    no clan defined TssO; Type VI secretion system, TssO (PF17561; HMM-score: 16.9)
    TEX13; Testis-expressed sequence 13 protein family (PF15186; HMM-score: 12)
    Cystatin (CL0121) Latexin; Latexin (PF06907; HMM-score: 11.4)
    no clan defined DUF3091; Protein of unknown function (DUF3091) (PF11291; HMM-score: 11)
    Sec2p; GDP/GTP exchange factor Sec2p (PF06428; HMM-score: 9.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.04
    • Cytoplasmic Membrane Score: 9.96
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 2
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.022486
    • TAT(Tat/SPI): 0.000107
    • LIPO(Sec/SPII): 0.014813
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000743662 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKQAYVIIALTSFLFVFFFSHSLLEILDFDWSIFLHDVEKTEKFVFLLLVFSMSITCLLALFWRGIEELSLRKMQANLKRLLAGQEVVQVADPDLDASFKSLSGKLNLLTEALQKAENHSLAQEEEIIEKERKRIARDLHDTVSQELFAAHMILSGISQQALKLDREKMQIQLQSVTAILETAQKDLRVLLLHLRPVELEQKSLIEGIQILLKELEDKSDLRVSLKQNMTKLPKKIEEHIFRILQELISNTLRHAQASCLDVYLYQTDVELQLKVVDNGIGFRLGSLDDLSYGLRNIKERVEDMAGTVQLLTAPKQGLAVDIRIPLLDKE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Vegard Eldholm, Beatrice Gutt, Ola Johnsborg, Reinhold Brückner, Patrick Maurer, Regine Hakenbeck, Thorsten Mascher, Leiv Sigve Håvarstein
The pneumococcal cell envelope stress-sensing system LiaFSR is activated by murein hydrolases and lipid II-interacting antibiotics.
J Bacteriol: 2010, 192(7);1761-73
[PubMed:20118250] [WorldCat.org] [DOI] (I p)

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