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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-FEB-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN994038
  • locus tag: SPN994038_RS05120 [old locus tag: SPN994038_09530 ]
  • pan locus tag?: PNEUPAN002141000
  • symbol: SPN994038_RS05120
  • pan gene symbol?: —
  • synonym:
  • product: thiamine pyrophosphate-dependent enzyme

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN994038_RS05120 [old locus tag: SPN994038_09530 ]
  • symbol: SPN994038_RS05120
  • product: thiamine pyrophosphate-dependent enzyme
  • replicon: chromosome
  • strand: +
  • coordinates: 957987..959084
  • length: 1098
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021026 (957987..959084) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATGAAAAGTAAAGATTTAATAAGTTCTTTGAAGTTAAATGGTGTAACTCGTTTTTTTGGG
    GTTCCAGATACTTTCTTGTATCCTATTACTTCACAATTAGCGAATGATGAATTGATAATT
    GTACCAAATGAGGGCAATGCAGTTTCAATGGCTTTTGGATATAGTATTACAACAAGTAGG
    ATGCCTGTAATTTTTTTACAAAATTCAGGATTAGGAAATATATTAGATCCTGTACAAAGT
    TTAGTGGGGCAAGCAGTTTATAATCATCCTATGCTCTATATAATTGGATTTCGGGGAGGA
    ACAGATGATGCTCCTCAGCATTCTGAGTGTGGTAAGGTAACAAAGAAGCTTTTGGAGATA
    AGTCAATTTGATATATATGAAAAAGATTATTTTACAAACGCCCTTGATACTGATATAAGA
    AGAATTATTGATAATATCAAAAAAAAGAATAAAAGTGCAGCCATTCTAGTGGATAAAGAA
    TTTTTTTCAGATATTGTTAATATAAAAAATTACCAAATTTCTGATTATAACGATATACTT
    AATAAAATATGTGCTGTTCTGGAAAAAGAGAAAGACTCTATTGTTCTCACATCAACAGGA
    TATATAACTCGTCATATGGAGAATGTAAAAGATACTTATAAAAAGAACTTTGTTCATATA
    CCTATGCCAGGCTCATTAGGACAAACAATATCTTTCGGTGCTGGTATATGTATGGGAACT
    TCTATAAATAATAAAAAAAAGAAAATATATATTATCGATGGAGATGGTTCCTTATTTATG
    CATATGGGTTCTTTAGCGTTATTTGATTATTATAATTTAGATGTTACATATATCTTGTTA
    AACAACTATAAACATCTATCAGTTGGGGGAGAAAACACATTAGCTTCGAGCTGTAATTTT
    TTTAAGTTAGCTGAATCTATGAATTTTGATAATATATATTCTAGTGATAATTTAGAAGTG
    GTTGATTTTGAGGAAAAATTAAATCAGCAAGGAAAGAATTTTATTGAAATAATTTGTTCT
    AATGAAGTGACTTATTCATTATTAGAAAGAATGGATTTTAATTTCGAAGAAATAAAACAA
    TTTAATATGGAGAATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1098

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN994038_RS05120 [old locus tag: SPN994038_09530 ]
  • symbol: SPN994038_RS05120
  • description: thiamine pyrophosphate-dependent enzyme
  • length: 365
  • theoretical pI: 4.99208
  • theoretical MW: 41277.9
  • GRAVY: -0.168493

⊟Function[edit | edit source]

  • TIGRFAM:
    phosphonopyruvate decarboxylase (TIGR03297; EC 4.1.1.82; HMM-score: 218.8)
    and 8 more
    sulfopyruvate decarboxylase, beta subunit (TIGR03846; EC 4.1.1.79; HMM-score: 67.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other sulfopyruvate decarboxylase, alpha subunit (TIGR03845; EC 4.1.1.79; HMM-score: 55.7)
    Metabolism Energy metabolism Methanogenesis sulfopyruvate decarboxylase, alpha subunit (TIGR03845; EC 4.1.1.79; HMM-score: 55.7)
    Metabolism Amino acid biosynthesis Pyruvate family acetolactate synthase, large subunit, biosynthetic type (TIGR00118; EC 2.2.1.6; HMM-score: 44.2)
    Metabolism Central intermediary metabolism Other sulfoacetaldehyde acetyltransferase (TIGR03457; EC 2.3.3.15; HMM-score: 24.1)
    Metabolism Energy metabolism Sugars 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase (TIGR04377; EC 3.7.1.-; HMM-score: 19.5)
    Metabolism Central intermediary metabolism Other indolepyruvate decarboxylase (TIGR03393; EC 4.1.1.74; HMM-score: 12.4)
    indolepyruvate/phenylpyruvate decarboxylase (TIGR03394; EC 4.1.1.43,4.1.1.74; HMM-score: 11.2)
  • TheSEED:
  • PFAM:
    THDP-binding (CL0254) TPP_enzyme_C; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain (PF02775; HMM-score: 51.9)
    TPP_enzyme_N; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain (PF02776; HMM-score: 42)
    and 3 more
    no clan defined DIT1_PvcA; Pyoverdine/dityrosine biosynthesis protein (PF05141; HMM-score: 13.8)
    P-loop_NTPase (CL0023) CobU; Cobinamide kinase / cobinamide phosphate guanyltransferase (PF02283; HMM-score: 13.4)
    SPOUT (CL0098) Trm56; tRNA ribose 2'-O-methyltransferase, aTrm56 (PF01994; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.712
    • Cytoplasmic Membrane Score: 0.0061
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.2817
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.034408
    • TAT(Tat/SPI): 0.000953
    • LIPO(Sec/SPII): 0.001882
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000836759 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKSKDLISSLKLNGVTRFFGVPDTFLYPITSQLANDELIIVPNEGNAVSMAFGYSITTSRMPVIFLQNSGLGNILDPVQSLVGQAVYNHPMLYIIGFRGGTDDAPQHSECGKVTKKLLEISQFDIYEKDYFTNALDTDIRRIIDNIKKKNKSAAILVDKEFFSDIVNIKNYQISDYNDILNKICAVLEKEKDSIVLTSTGYITRHMENVKDTYKKNFVHIPMPGSLGQTISFGAGICMGTSINNKKKKIYIIDGDGSLFMHMGSLALFDYYNLDVTYILLNNYKHLSVGGENTLASSCNFFKLAESMNFDNIYSSDNLEVVDFEEKLNQQGKNFIEIICSNEVTYSLLERMDFNFEEIKQFNMEN

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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