PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 24-FEB-2025

⊟Summary

• organism: Streptococcus pneumoniae SPN994038
• locus tag: SPN994038_RS06935 [old locus tag: SPN994038_12910 ]
• pan locus tag^?: PNEUPAN002766000
• symbol: SPN994038_RS06935
• pan gene symbol^?: mocA
• synonym:
• product: Gfo/Idh/MocA family protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPN994038_RS06935 [old locus tag: SPN994038_12910 ]
• symbol: SPN994038_RS06935
• product: Gfo/Idh/MocA family protein
• replicon: chromosome
• strand: +
• coordinates: 1310738..1311715
• length: 978
• essential: unknown

⊟Accession numbers

• Location: NC_021026 (1310738..1311715) NCBI
• BioCyc:
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1311 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  
  ATGCTAAAATTAGGTGTCATCGGAACTGGCGCTATCAGCCATCATTTCATAGAAGCAGCC
  CATACCAGTGGAGAATACCAACTGGTCGCAATCTATTCTAGAAAACTAGAAACTGCAACA
  ACCTTTGCTTCTCGCTATCAGAATATCCAACTATTCGATCAATTAGAAGTCTTCTTCAAA
  TCTTCTTTTGATTTAGTTTATATCGCCAGTCCAAACTCCTTACATTTTGCTCAGGCAAAA
  GCTGCCTTGTCTGCTGGTAAACATGTTATTCTTGAAAAGCCAGCTGTCACTCAACCACAA
  GAATGGTTTGATTTGATTCAAACAGCTGAAAAAAATAACTGTTTTATCTTTGAAGCAGCT
  CGTAATTACCACGAGAAAGCCTTTACTACTATCAAAAACTTTTTAGCAGATAAGCAAGTG
  TTAGGAGCAGATTTCAACTATGCCAAATACTCTTCCAAGATGCCTGACTTGTTGGCTGGA
  CAAACACCAAATGTCTTTTCAGACCGTTTTGCTGGTGGAGCCCTCATGGATTTGGGAATT
  TATCCCCTCTATGCTGCTGTTCGTCTTTTTGGAAAAGCTAATGACGCGACTTACCATGCT
  CAACAGCTTGACAATAGCATTGACCTAAATGGAGATGGTATCCTCTTCTACCCAGACTAT
  CAAGTTCACATCAAGGCTGGAAAAAACATCACTTCCAATCTTCCTTGCGAGATTTATACA
  ACAGATGGAACCTTGACTCTCAACACGATTGAGCATATTCGCTCAGCTATTTTTACCGAC
  CACCAAGGAAATCAAGTCCAGCTTCCTATCCAACAGACTCATCATACGATGACTGAGGAA
  GTCGCTGCATTTGCACACATGATCCAGCAACCAGATCTGAATCTCTACCAAACTTGGCTG
  GATGATGCAGGCTCTGTTCATGAGCTACTATATACCATGCGCCAGACTGCTGGCATTAGA
  TTTGAGGCAGAAAAATGA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  978
  

⊟Protein

⊟General

• locus tag: SPN994038_RS06935 [old locus tag: SPN994038_12910 ]
• symbol: SPN994038_RS06935
• description: Gfo/Idh/MocA family protein
• length: 325
• theoretical pI: 6.13758
• theoretical MW: 36439.9
• GRAVY: -0.186769

⊟Function

• TIGRFAM:
  Metabolism Energy metabolism Sugars inositol 2-dehydrogenase (TIGR04380; EC 1.1.1.18; HMM-score: 49.7)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  NADP_Rossmann (CL0063) GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold (PF01408; HMM-score: 84.1)
  and 7 more
  NAD_binding_3; Homoserine dehydrogenase, NAD binding domain (PF03447; HMM-score: 23)
  F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 20.1)
  Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain (PF01118; HMM-score: 18.9)
  Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain (PF03435; HMM-score: 18.3)
  DapB_N; Dihydrodipicolinate reductase, N-terminus (PF01113; HMM-score: 14.7)
  GADPH_aa-bio_dh (CL0139) GFO_IDH_MocA_C; Oxidoreductase family, C-terminal alpha/beta domain (PF02894; HMM-score: 13.8)
  NADP_Rossmann (CL0063) Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 12.9)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9978
  • Cytoplasmic Membrane Score: 0.0003
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0018
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.027242
  • TAT(Tat/SPI): 0.000589
  • LIPO(Sec/SPII): 0.006997
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000915905 NCBI
• UniProt:

⊟Protein sequence

• MLKLGVIGTGAISHHFIEAAHTSGEYQLVAIYSRKLETATTFASRYQNIQLFDQLEVFFKSSFDLVYIASPNSLHFAQAKAALSAGKHVILEKPAVTQPQEWFDLIQTAEKNNCFIFEAARNYHEKAFTTIKNFLADKQVLGADFNYAKYSSKMPDLLAGQTPNVFSDRFAGGALMDLGIYPLYAAVRLFGKANDATYHAQQLDNSIDLNGDGILFYPDYQVHIKAGKNITSNLPCEIYTTDGTLTLNTIEHIRSAIFTDHQGNQVQLPIQQTHHTMTEEVAAFAHMIQQPDLNLYQTWLDDAGSVHELLYTMRQTAGIRFEAEK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1311 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications