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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 27-FEB-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPNA45
  • locus tag: SPNA45_00972 [new locus tag: SPNA45_RS05465 ]
  • pan locus tag?: PNEUPAN002454000
  • symbol: cysD
  • pan gene symbol?: cysD
  • synonym:
  • product: O-acetylhomoserine (thiol)-lyase (pseudogene)

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNA45_00972 [new locus tag: SPNA45_RS05465 ]
  • symbol: cysD
  • product: O-acetylhomoserine (thiol)-lyase (pseudogene)
  • replicon: chromosome
  • strand: +
  • coordinates: join(963453..963572,963576..964712)
  • length: 1257
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: HE983624 join(963453..963572,963576..964712) NCBI
  • BioCyc: see SPNA45_RS05465
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_2310 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGACTTGTGATTTTAAATTTGAAACTCTACAACTACATGCTGGTCAAGTTGTGGCTCCA
    GCTACTAAGTCTCGTGCAGTGCCGATTTATCAAACAACATTTTTTGTTTTTGATGACACG
    GAAGGTGCCGATATGTTTGCCTTGAGGAAACCAGGGAACATTTATACTCGTATCACCAAT
    CCTACAACAGCTGCCCTTGAAGGTGGTGTTGAAGCGCTAGCAACAGCATCAGGTATGACT
    GCAGTGACTTATACTATTTTGGCGATTGCCCATGCTGGTGACCATGTAGTGGCTGCTTCG
    ACTATTTACGGTGGAACCTTCAATCTTTTGAAAGAACCCCTTCCTCGTTATGGTATCACA
    ACAACCTTTGTCGATATTGATAATTTGGAGGAAGTAGAAGCAGCTATCAAAGACAATACC
    AAGCTTGTCTTGATTGAAACCTTGGGTAACCCCTTGATTAATATTCCAGACCTGGAAAAA
    CTGGCAGAGATTGCTCATAAACATCAAATCCCACTTGTGTCAGACAATACTTTTGCAACA
    CCTTATTTGATTAACGTCTTCTCTCATGGCGTTGACATTGCCATTCACTCTGCGACTAAG
    TTTATCGGTGGGCATGGTACAACTATTGGAGGAATAATTGTCGATAGTGGTCGTTTTGAC
    TGGACGGCTTCAGGGAAATTCCCTCAATTTGTTGACGAGGGTCCAAGCTGCCACAATTTG
    AGTTATACTCGTGATGTGGGTGCAGCAGCCTTTATTATAGCTGTTCGAGTTCAATTGCTT
    CGTGATACAGGTGCAGCCTTGTCACCATTCAATGCTTTCCTCTTGCTACAAAGACTTGAA
    ACCCTTTCACTTCGTGTGGAACGCCATGTACAAAATGCTGAGACAATTGTTGATTTTCTT
    GTCAACCATCCTAAGGTAGAAAAGGTAAATTATCCAAAACTTGCAGATAGTCCTTATTAT
    GCCTTGGCTGAGAAATACTTGCCAAAAGGTGTCGGTTCAATCTTTACCTTCCACGTCAAA
    GGTGACGAGGAAGAAGCACGCAAGGTTATTGATAATTTAGAAATCTTTTCTGACCTTGCA
    AACGCGGCAGATGCTAAATCGCTTGTTGTCCATCCAGCAACAATCACTCACGGTCAATTG
    TCAGAAAAAGACCTAGAAGCAGCAGGTGTCACACCAAATCAAATCCACTTGTCTATCGGT
    CTTGAAAATGTAGAAGATTTGATTGAAGACTTACGCTTGGCCTTGGAAAAAATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1257

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNA45_00972 [new locus tag: SPNA45_RS05465 ]
  • symbol: CysD
  • description: O-acetylhomoserine (thiol)-lyase (pseudogene)
  • length: 418
  • theoretical pI: 5.04004
  • theoretical MW: 45445.4
  • GRAVY: 0.0767943

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Amino acid biosynthesis Aspartate family O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase (TIGR01326; HMM-score: 577.2)
    Metabolism Amino acid biosynthesis Serine family O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase (TIGR01326; HMM-score: 577.2)
    and 20 more
    Metabolism Energy metabolism Amino acids and amines methionine gamma-lyase (TIGR01328; EC 4.4.1.11; HMM-score: 345.7)
    Metabolism Amino acid biosynthesis Aspartate family O-succinylhomoserine sulfhydrylase (TIGR01325; EC 4.2.99.-; HMM-score: 342.2)
    Metabolism Amino acid biosynthesis Aspartate family O-succinylhomoserine (thiol)-lyase (TIGR02080; EC 2.5.1.48; HMM-score: 256.4)
    cystathionine beta-lyase (TIGR01329; EC 4.4.1.8; HMM-score: 218.9)
    Metabolism Amino acid biosynthesis Aspartate family cystathionine beta-lyase (TIGR01324; EC 4.4.1.8; HMM-score: 150.9)
    Genetic information processing Protein synthesis tRNA and rRNA base modification cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 24.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 24.5)
    tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 22.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase, SufS family (TIGR01979; HMM-score: 22.9)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01976; HMM-score: 22.7)
    Metabolism Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 21.1)
    cysteine desulfurase, NifS family (TIGR03403; EC 2.8.1.7; HMM-score: 19.3)
    Unknown function Enzymes of unknown specificity uncharacterized pyridoxal phosphate-dependent enzyme (TIGR01437; HMM-score: 19.2)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 18.9)
    O-phospho-L-seryl-tRNA:Cys-tRNA synthase (TIGR02539; EC 2.5.1.73; HMM-score: 17.6)
    cysteine desulfurase NifS (TIGR03402; EC 2.8.1.7; HMM-score: 16.6)
    putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 16.5)
    Genetic information processing DNA metabolism Restriction/modification cysteine desulfurase DndA (TIGR03235; EC 2.8.1.7; HMM-score: 15.1)
    UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase (TIGR03588; EC 2.6.1.92; HMM-score: 11.9)
    aminotransferase, LLPSF_NHT_00031 family (TIGR04181; HMM-score: 10.4)
  • TheSEED: data available for D39
  • PFAM:
    PLP_aminotran (CL0061) Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 422.7)
    and 6 more
    DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 37.1)
    Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 33)
    Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 31.8)
    SepSecS; O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS (PF05889; HMM-score: 15.2)
    no clan defined DCR; Dppa2/4 conserved region (PF14047; HMM-score: 13.1)
    PLP_aminotran (CL0061) Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 11.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9293
    • Cytoplasmic Membrane Score: 0.0053
    • Cell wall & surface Score: 0.0016
    • Extracellular Score: 0.0638
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.048673
    • TAT(Tat/SPI): 0.023533
    • LIPO(Sec/SPII): 0.010931
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CCM08257 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTCDFKFETLQLHAGQVVAPATKSRAVPIYQTTFFVFDDTEGADMFALRKPGNIYTRITNPTTAALEGGVEALATASGMTAVTYTILAIAHAGDHVVAASTIYGGTFNLLKEPLPRYGITTTFVDIDNLEEVEAAIKDNTKLVLIETLGNPLINIPDLEKLAEIAHKHQIPLVSDNTFATPYLINVFSHGVDIAIHSATKFIGGHGTTIGGIIVDSGRFDWTASGKFPQFVDEGPSCHNLSYTRDVGAAAFIIAVRVQLLRDTGAALSPFNAFLLLQRLETLSLRVERHVQNAETIVDFLVNHPKVEKVNYPKLADSPYYALAEKYLPKGVGSIFTFHVKGDEEEARKVIDNLEIFSDLANAADAKSLVVHPATITHGQLSEKDLEAAGVTPNQIHLSIGLENVEDLIEDLRLALEKI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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