PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 27-FEB-2015

⊟Summary

• organism: Streptococcus pneumoniae SPNA45
• locus tag: SPNA45_01667 [new locus tag: SPNA45_RS09330 ]
• pan locus tag^?: PNEUPAN001248000
• symbol: SPNA45_01667
• pan gene symbol^?: mvaK2
• synonym:
• product: Phosphomevalonate kinase (EC 2.7.4.2)

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNA45_01667 [new locus tag: SPNA45_RS09330 ]
• symbol: SPNA45_01667
• product: Phosphomevalonate kinase (EC 2.7.4.2)
• replicon: chromosome
• strand: -
• coordinates: 1693110..1694117
• length: 1008
• essential: unknown other strains

⊟Accession numbers

• Location: HE983624 (1693110..1694117) NCBI
• BioCyc: see SPNA45_RS09330
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0348 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  481
  541
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  661
  721
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  841
  901
  961
  
  ATGATTGCTGTTAAAACTTGCGGAAAACTCTATTGGGCAGGTGAATATGCTATTTTAGAG
  CCAGGGCAGTTAGCTTTGATAAAGGATATTCCCATCTATATGAGGGCTGAGATTGCTTTT
  TCTGACAGCTACCGTATCTATTCAGATATGTTTGATTTCGCAGTGGACTTAACGCCCAAT
  CCTGACTATAGCTTGATTCAAGAAACGATTGCTTTGATGGGAGACTTCCTCGCTGTTCGT
  GGTCAGAATTTAAGACCTTTTTCTCTAGAAATCTGTGGCAAAATGGAACGAGAAGGGAAA
  AAGTTTGGTCTAGGTTCTAGTGGCAGCGTCGTTGTCTTGGTTGTCAAGGCTTTACTGGCT
  CTGTATGATGTTTCTGTTGATCAGGAGCTCTTGTTCAAGCTGACTAGCGCTGTCTTGCTC
  AAGCGAGGAGACAATGGTTCCATGGGCGACCTTGCCTGTATTGTGGCAGAGGATTTGGTT
  CTCTACCAGTCATTTGATCGCCAGAAGGTGGCTGCTTGGTTAGAAGAAGAAAACTTGGCG
  ACAGTTCTGGAGCGTGATTGGGGATTTTTTATCTCACAAGTGAAACCAACTTTAGAATGT
  GATTTCTTAGTGGGATGGACCAAGGAAGTGGCTGTATCGAGTCACATGGTCCAGCAAATC
  AAGCAAAATATCAATCAAAATTTTTTAACTTCCTCAAAAGAAACGGTGGTTTCTTTGGTC
  GAAGCCTTGGAACAGGGGAAATCAGAAAAGATTATCGAGCAAGTAGAAGTAGCCAGCAAG
  CTTTTAGAAGGCTTGAGTACAGATATTTACACGCCTTTGCTTAGACAGTTGAAAGAAGCC
  AGTCAAGATTTGCAGGCCGTTGCCAAGAGTAGTGGTGCTGGTGGTGGTGACTGTGGCATC
  GCCCTGAGTTTTGATGCGCAATCAACCAAAACCTTAAAAAATCGTTGGGCCGATCTGGGG
  ATTGAGCTCTTATATCAAGAAAGGATAGGACATGACGACAAATCGTAA
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  1008
  

⊟Protein

⊟General

• locus tag: SPNA45_01667 [new locus tag: SPNA45_RS09330 ]
• symbol: SPNA45_01667
• description: Phosphomevalonate kinase (EC 2.7.4.2)
• length: 335
• theoretical pI: 4.48164
• theoretical MW: 37059.3
• GRAVY: 0.0214925

⊟Function

• TIGRFAM:
  Metabolism Central intermediary metabolism Other phosphomevalonate kinase (TIGR01220; EC 2.7.4.2; HMM-score: 191.4)
  and 4 more
  Metabolism Central intermediary metabolism Other mevalonate kinase (TIGR00549; EC 2.7.1.36; HMM-score: 54.8)
  Unknown function Enzymes of unknown specificity pyridoxal phosphate enzyme, MJ0158 family (TIGR03576; HMM-score: 12.7)
  Metabolism Central intermediary metabolism Other phosphomevalonate kinase (TIGR01219; EC 2.7.4.2; HMM-score: 11.3)
  Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate kinase (TIGR01920; EC 2.7.1.71; HMM-score: 11.2)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  S5 (CL0329) GHMP_kinases_N; GHMP kinases N terminal domain (PF00288; HMM-score: 35.8)
  and 3 more
  GHMP_C (CL0677) GHMP_kinases_C; GHMP kinases C terminal (PF08544; HMM-score: 24.1)
  no clan defined Vta1; Vta1 like (PF04652; HMM-score: 13.8)
  mRNA_stabil; mRNA stabilisation (PF13929; HMM-score: 13.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 1.78
  • Cytoplasmic Membrane Score: 8.16
  • Cellwall Score: 0.06
  • Extracellular Score: 0.01
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.00432
  • TAT(Tat/SPI): 0.000118
  • LIPO(Sec/SPII): 0.000682
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: CCM08952 NCBI
• UniProt:

⊟Protein sequence

• MIAVKTCGKLYWAGEYAILEPGQLALIKDIPIYMRAEIAFSDSYRIYSDMFDFAVDLTPNPDYSLIQETIALMGDFLAVRGQNLRPFSLEICGKMEREGKKFGLGSSGSVVVLVVKALLALYDVSVDQELLFKLTSAVLLKRGDNGSMGDLACIVAEDLVLYQSFDRQKVAAWLEEENLATVLERDWGFFISQVKPTLECDFLVGWTKEVAVSSHMVQQIKQNINQNFLTSSKETVVSLVEALEQGKSEKIIEQVEVASKLLEGLSTDIYTPLLRQLKEASQDLQAVAKSSGAGGGDCGIALSFDAQSTKTLKNRWADLGIELLYQERIGHDDKS

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0348 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications