PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 27-FEB-2015

⊟Summary

• organism: Streptococcus pneumoniae SPNA45
• locus tag: SPNA45_02044 [new locus tag: SPNA45_RS11350 ]
• pan locus tag^?: PNEUPAN003889000
• symbol: cbpA
• pan gene symbol^?: cbpA
• synonym: pspC
• product: choline-binding surface protein A

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNA45_02044 [new locus tag: SPNA45_RS11350 ]
• symbol: cbpA
• product: choline-binding surface protein A
• replicon: chromosome
• strand: -
• coordinates: 2080098..2081489
• length: 1392
• essential: unknown

⊟Accession numbers

• Location: HE983624 (2080098..2081489) NCBI
• BioCyc: see SPNA45_RS11350
• MicrobesOnline:
• PneumoBrowse for strain D39V:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  1021
  1081
  1141
  1201
  1261
  1321
  1381
  
  ATGTTTGCATCAAAAAGCGAAAGAAAAGTACATTATTCAATTCGTAAATTTAGTATTGGA
  GTAGCTAGTGTAGTAGTTGCTAGCTTGTTCTTAGGAGGAGTAGTTCATGCGACAGAGAAC
  GAGGGAATTACCCAAGTAGCCACTTCTTCTAATATGGCAAAGACAGAACATAGGAAAGCT
  GCTGAACAAGTCGATGAATATATAAACAAAATGATCCAATTAGATAAAAGAAAACATACC
  CAAAATCTCGCCTTAAACATAAAGTTGAGCGCAATTAAAACGAAGTATTTGCGTGAATTA
  AATGTTTTAGAAGAGAAGTCGAAAAAAGAAGAGTTGACGTCAAAAACAAAAAAAGAGATA
  GACGCAGCTTTTGAGCAGTTTAACAAAGATACATTGAAACCAGGAGAAAAGGTTGCAGAA
  GCTCAGAAAAAAGCCAAGGATCAAAAAGAAGAAGATCGCCGTAACTACCCAACCAATACT
  TACAAAACGCTTGAACTTGAAATTGCTGAGTCCGATGTGAAAGTTAAAGAAGCGGAGCTT
  GAACTAGTAAAAGAGGAAGCTAAGGGATCTCGAGACGAGGAAAAAATTAAGCAAGCAAAA
  GCGAAAGTTGAGAGTAAAAAAGCAGAAGAAGAAGCTAAACGAAAAGCAGCAGAAGAAGAT
  AAAGTTAAAGAAAAACCAGCTGAACAACCACAACCAGCGCCGGCTCCTCAACCAGAAAAA
  CCAACTGAAGAGCCTGAGAATCCAGCTCCAGCTCCAAAACCAGAGAATCCAGCTGAACAA
  CCAAAAGCAGAAAAAACAGATGATCAACAAGCTGAAGAAGACTATGCTCGTAGATCAGAA
  GAAAAATATAATCGCTTGACTCAACAGCAACCGCCAAAAACTGAAAAACCAGCACAACCA
  TCTACTCCAAAAACAGGCTGGAAACAAGAAAACGGTATGTGGTACTTCTACAATACTGAT
  GGTTCAATGGCGACAGGATGGCTCCAAAACAACGGTTCATGGTACTACCTCAACGCTAAT
  GGTGCTATGGTAACAGGATGGCTCCAAAACAATGGTTCATGGTACTACCTAAACAGCAAT
  GGCGCTATGGCGACAGGATGGCTCCAATACAATGGCTCATGGTACTACCTCAACGCTAAT
  GGTGATATGGCGACAGGATGGCTCCAAAACAACGGTTCATGGTACTACCTCAACGCTAAC
  GGTTCAATGGCAACAGGTTGGGTGAAAGATGGAGATACCTGGTACTATCTTGAAGCATCA
  GGTGCTATGAAAGCAAGCCAATGGTTCAAAGTATCAGATAAATGGTACTATGTCAATGGC
  TCAGGTGCCCTTGCAGTCAACACAACTGTAGATGGCTATGGAGTCAATGCCAATGGTGAA
  TGGGTAAACTAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  1020
  1080
  1140
  1200
  1260
  1320
  1380
  1392
  

⊟Protein

⊟General

• locus tag: SPNA45_02044 [new locus tag: SPNA45_RS11350 ]
• symbol: CbpA
• description: choline-binding surface protein A
• length: 463
• theoretical pI: 6.24515
• theoretical MW: 52314.8
• GRAVY: -1.01987

⊟Function

• TIGRFAM:
  gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 55.9)
  glucan-binding repeat (TIGR04035; HMM-score: 49.4)
  and 1 more
  delta-60 repeat domain (TIGR02608; HMM-score: 5.2)
• TheSEED:
• PFAM:
  Choline_binding (CL0694) Choline_bind_1; Putative cell wall binding repeat (PF01473; HMM-score: 141.5)
  Choline_bind_3; Choline-binding repeat (PF19127; HMM-score: 127.2)
  and 4 more
  no clan defined RICH; RICH domain (PF05062; HMM-score: 81.8)
  Choline_binding (CL0694) Choline_bind_2; Choline-binding repeat (PF19085; HMM-score: 44.1)
  no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 42.7)
  DUF4224; Domain of unknown function (DUF4224) (PF13986; HMM-score: 13)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Extracellular
  • Cytoplasmic Score: 0.01
  • Cytoplasmic Membrane Score: 0.09
  • Cellwall Score: 0.18
  • Extracellular Score: 9.72
  • Internal Helix: 1
• DeepLocPro: Cell wall & surface
  • Cytoplasmic Score: 0.002
  • Cytoplasmic Membrane Score: 0.0009
  • Cell wall & surface Score: 0.8619
  • Extracellular Score: 0.1352
• SignalP: Signal peptide SP(Sec/SPI) length 37 aa
  • SP(Sec/SPI): 0.968079
  • TAT(Tat/SPI): 0.017062
  • LIPO(Sec/SPII): 0.003623
  • Cleavage Site: CS pos: 37-38. VHA-TE. Pr: 0.9514
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI:
• RefSeq: CCM09327 NCBI
• UniProt:

⊟Protein sequence

• MFASKSERKVHYSIRKFSIGVASVVVASLFLGGVVHATENEGITQVATSSNMAKTEHRKAAEQVDEYINKMIQLDKRKHTQNLALNIKLSAIKTKYLRELNVLEEKSKKEELTSKTKKEIDAAFEQFNKDTLKPGEKVAEAQKKAKDQKEEDRRNYPTNTYKTLELEIAESDVKVKEAELELVKEEAKGSRDEEKIKQAKAKVESKKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQPEKPTEEPENPAPAPKPENPAEQPKAEKTDDQQAEEDYARRSEEKYNRLTQQQPPKTEKPAQPSTPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWYYLNANGAMVTGWLQNNGSWYYLNSNGAMATGWLQYNGSWYYLNANGDMATGWLQNNGSWYYLNANGSMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDGYGVNANGEWVN

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V:

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications