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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPNA45
  • locus tag: SPNA45_RS00525 [old locus tag: SPNA45_00094 ]
  • pan locus tag?: PNEUPAN003705000
  • symbol: SPNA45_RS00525
  • pan gene symbol?: —
  • synonym:
  • product: CPBP family intramembrane metalloprotease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNA45_RS00525 [old locus tag: SPNA45_00094 ]
  • symbol: SPNA45_RS00525
  • product: CPBP family intramembrane metalloprotease
  • replicon: chromosome
  • strand: +
  • coordinates: 91796..92437
  • length: 642
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_018594 (91796..92437) NCBI
  • BioCyc: SPNA45_RS00525 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1944 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGAAATTACTTAAAAACCTTGGCTGGATTCTTCTAGCCCTTCTATCCTTTTTATTTATC
    TATGGCTTTATTCAGGGGCTCGCGACTGCGTCGCTTGCTTTAGGCGCTTCACCCTATGCT
    GTTACTCTACTCTATGTGGCCTTGGCTGGAGTATATGTGTACGGCATTTACAAATGGTAT
    CAGAAGGCTCCTGTTCATATTGAGAAGAGCGGCTTTAATCGATTTATTTGGCTTCCTGTC
    TTGGTTTGGTTCTTATCTCTGGTCGTTCAATTTTTCTTGCCAGATGATCCTTCAGTAAAT
    CAACAAATAGCGACAGACTTGACCTTGTCTCAACCACTTTTCTCATTCTTTGCTGTGGTT
    ATTTTTGCTCCTTTGACGGAAGAGATTGTTTTTAGAGGGATGTTAGCACGCTATCTCTTT
    CCTAAGCAGGACAATAGTAAACGAACCCTGATTTTTCTTCTGGTATCTAGTCTTCTATTT
    GCCTTGATTCATTTTCCAGGTGATGTGCAACAATTTTTTGTCTATTTTAGCCTTGGTTTT
    AGTTTGGGTTTGGCTTACATTAGCAGAAAAGGTCTGGTCTACAGTATTTCTCTTCACGCT
    TTGAATAATTTAGTCGGCTTTTTGATGATTCTCATGCTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    642

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNA45_RS00525 [old locus tag: SPNA45_00094 ]
  • symbol: SPNA45_RS00525
  • description: CPBP family intramembrane metalloprotease
  • length: 213
  • theoretical pI: 9.75109
  • theoretical MW: 24099.6
  • GRAVY: 0.911268

⊟Function[edit | edit source]

  • TIGRFAM:
    exosortase E/protease, VPEID-CTERM system (TIGR04162; EC 3.4.22.-; HMM-score: 25.8)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides CAAX prenyl protease-related protein (TIGR03008; HMM-score: 23.7)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Peptidase_U (CL0472) Rce1-like; Type II CAAX prenyl endopeptidase Rce1-like (PF02517; HMM-score: 69.6)
    and 2 more
    no clan defined NMN_transporter; Nicotinamide mononucleotide transporter (PF04973; HMM-score: 11)
    DUF5389; Family of unknown function (DUF5389) (PF17364; HMM-score: 6.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 5
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.155721
    • TAT(Tat/SPI): 0.013668
    • LIPO(Sec/SPII): 0.037103
  • predicted transmembrane helices (TMHMM): 7

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000771238 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLLKNLGWILLALLSFLFIYGFIQGLATASLALGASPYAVTLLYVALAGVYVYGIYKWYQKAPVHIEKSGFNRFIWLPVLVWFLSLVVQFFLPDDPSVNQQIATDLTLSQPLFSFFAVVIFAPLTEEIVFRGMLARYLFPKQDNSKRTLIFLLVSSLLFALIHFPGDVQQFFVYFSLGFSLGLAYISRKGLVYSISLHALNNLVGFLMILML

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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