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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 14-DEC-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPNA45
  • locus tag: SPNA45_RS03975
  • pan locus tag?: PNEUPAN002810000
  • symbol: SPNA45_RS03975
  • pan gene symbol?: lmrA_2
  • synonym:
  • product: ABC transporter ATP-binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNA45_RS03975
  • symbol: SPNA45_RS03975
  • product: ABC transporter ATP-binding protein
  • replicon: chromosome
  • strand: +
  • coordinates: 692086..693021
  • length: 936
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_018594 (692086..693021) NCBI
  • BioCyc: SPNA45_RS03975 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGAAATTAAAATTATTAAGAGTAGATACTAAGGTGATTATGGGGAGTTTCTTACTTGTT
    CTGTCTAGTCTACTTGCTTTGTTGCTTCCCCTTATCTTAAAGGGTTTAATAGATGGGAGT
    TCTATTGAAAATATAGGTTCCAAAGTATTTCAATCGTTTTTGATTTTTATTGGTCAAGCC
    TTGTTTTCTTCTATTGGTTACTATCTGTTTAGTCAATCGGGTGAAAAAAAGATAGCAAAA
    ATCAGGAAAAAAGTGATAGAGGGGTTGATTTATGCAGAGAAATCCTTCTTTGATAAGAGA
    CAAAGTGGGGAGTTGACTTCTGCCATTGTCAATGACACGAGTGTCATTCGTGAGTTTTTA
    ATTACGACTTTCCCAAATATTATTCTGAGTTTAGTTATGGTACTTGGTTCCATTGTAGTC
    TTATTTAGTCTTGATTGGAATCTTTCTCTACTTTTATTCATCACTCTTCCTTGTATGATG
    TTTATTATCTTGCCCCTTTCCAATATCAGTGAAAAGTATAGTCGTCGTTTACAGGAGGAA
    ATCGGATTTTTAACAGGGCAATTGACTGAAAAGATTCAAGAACATGAATTAATTAAGACT
    AACCAAGCAGAGAAAAGTGTACAGGATGTTTTGGATAATTGTATTGAAAGGGTACAAAAC
    AATTCACTGAAATCAGATAGGGTTACTTCTTTTGAGACCCCGTTTGCTCTCTTATTTATC
    TTTGCGACTATAGCTGTGATGCTAACCTATGGGGGTTATCGGGTCAGCGCAGGATATATA
    TATGTGGGAACCTTGGTTTCGTTTTTGATTTACCTCTTTCAATTACTTAATCCTATTAGT
    AATATAGCTAATTTTGTAACTGTTTATTCTAGGAGCAAGGGATCTTCAGTTGCACTGGAG
    AACTTGCTTGCAGTTCCTAAAGAAAAATTTGAGTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    936

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNA45_RS03975
  • symbol: SPNA45_RS03975
  • description: ABC transporter ATP-binding protein
  • length: 311
  • theoretical pI: 9.18223
  • theoretical MW: 34877
  • GRAVY: 0.508682

⊟Function[edit | edit source]

  • TIGRFAM:
    ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 113.7)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 100)
    Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 100)
    Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 92.6)
    and 13 more
    Cellular processes Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 69.7)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 69.7)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 61.3)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 61.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 59.1)
    Genetic information processing Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 59.1)
    Metabolism Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 59.1)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 52.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 52.9)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 51.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 50.9)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 39.7)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 23.6)
  • TheSEED:
  • PFAM:
    ABC_membrane (CL0241) ABC_membrane; ABC transporter transmembrane region (PF00664; HMM-score: 139.3)
    and 4 more
    ABC_membrane_3; ABC transporter transmembrane region (PF13748; HMM-score: 17.2)
    no clan defined DUF2207; Predicted membrane protein (DUF2207) (PF09972; HMM-score: 12.1)
    RseC_MucC; Positive regulator of sigma(E), RseC/MucC (PF04246; HMM-score: 10.3)
    DUF3671; Protein of unknown function (PF12420; HMM-score: 8.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 6
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.995
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.005
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.041726
    • TAT(Tat/SPI): 0.001071
    • LIPO(Sec/SPII): 0.022762
  • predicted transmembrane helices (TMHMM): 6

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000768986 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKLKLLRVDTKVIMGSFLLVLSSLLALLLPLILKGLIDGSSIENIGSKVFQSFLIFIGQALFSSIGYYLFSQSGEKKIAKIRKKVIEGLIYAEKSFFDKRQSGELTSAIVNDTSVIREFLITTFPNIILSLVMVLGSIVVLFSLDWNLSLLLFITLPCMMFIILPLSNISEKYSRRLQEEIGFLTGQLTEKIQEHELIKTNQAEKSVQDVLDNCIERVQNNSLKSDRVTSFETPFALLFIFATIAVMLTYGGYRVSAGYIYVGTLVSFLIYLFQLLNPISNIANFVTVYSRSKGSSVALENLLAVPKEKFE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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