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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 03-APR-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu15
  • locus tag: SPNHU15_00186 [new locus tag: SPNHU15_RS00905 ]
  • pan locus tag?: PNEUPAN003150000
  • symbol: SPNHU15_00186
  • pan gene symbol?: mvaS
  • synonym:
  • product: hydroxymethylglutaryl-CoA synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU15_00186 [new locus tag: SPNHU15_RS00905 ]
  • symbol: SPNHU15_00186
  • product: hydroxymethylglutaryl-CoA synthase
  • replicon: chromosome
  • strand: -
  • coordinates: 179812..181008
  • length: 1197
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: CP020551 (179812..181008) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1537 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGAATGATAAAACAGAGGTAAATATGACAATCGGTATTGATAAGATTGGTTTTGCGACC
    AGTCAATATGTCTTGAAATTACAAGACTTAGCAGAAGCGAGGGGAATTGACCCTGAAAAA
    TTAAGTAAAGGACTCTTACTCAAGGAATTGAGTATTGCGCCCCTAACTGAGGACATTGTG
    ACCTTGGCGGCCAGTGCTAGTGACTCTATTTTAACTGAGCAAGAAAGACAAGAAGTTGAC
    ATGGTCATTGTGGCTACCGAGTCAGGAATTGACCAGAGTAAGGCTGCGGCCGTCTTTGTG
    CATGGCTTGCTGGGCATCCAGCCCTTTGCTCGTAGTTTCGAGATTAAAGAAGCCTGTTAT
    GGAGCGACTGCTGCCCTTCATTATGCCAAATTGCATGTGGAAAATTCTCCGGAGTCCAAG
    GTCTTGGTCATTGCCAGTGATATTGCCAAATACGGTATTGAAACTCCAGGAGAACCAACT
    CAAGGTGCTGGAAGTGTAGCTATGTTGATTACACAAAATCCACGCATGATGGCCTTTAAT
    AATGACAATGTAGCTCAGACCCGTGACATCATGGATTTCTGGCGACCAAATTACTCGACA
    ACTCCTTATGTAAATGGTGTTTATTCTACCCAACAATACTTGGATAGTTTGAAAACGACT
    TGGCTTGAATATCAAAAACGCTACCAGCTTACTCTGGATGATTTTGCGGCTGTTTGTTTC
    CACTTGCCTTATCCTAAATTAGCGCTAAAAGGCTTGAAAAAAATCATGGATAAGAGCCTG
    CCTCAAGAGAAAAAAGACCTCTTACAAAAGCATTTTGACCAGTCTATTCTCTACAGTCAA
    AAGGTGGGGAATATCTACACAGGTTCACTTTTCCTTGGACTTTTGTCTCTCTTGGAAAAT
    ACAGATAGCTTGAAAGCTGGGGATAAAATCGCCCTTTATAGTTACGGAAGTGGAGCTGTG
    GCTGAGTTCTTCAGTGGTGAATTGGTTGAAGGATATGAAGCTTATTTGGATAAAGACCGT
    TTGAACAAGCTCAACCAACGAACTGCCCTATCCGTTGCAGACTATGAAAAGGTCTTTTTT
    GAGGAAGTAAACTTGGATGAAACAAACTCTGCCCAGTTTGCTGGCTATGAAAATCAAGAT
    TTTGCCTTGGTTGAAATTCTTGACCACCAACGCCGTTATAGCAAGGTTGAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1197

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU15_00186 [new locus tag: SPNHU15_RS00905 ]
  • symbol: SPNHU15_00186
  • description: hydroxymethylglutaryl-CoA synthase
  • length: 398
  • theoretical pI: 4.72002
  • theoretical MW: 44435.1
  • GRAVY: -0.24598

⊟Function[edit | edit source]

  • TIGRFAM:
    hydroxymethylglutaryl-CoA synthase (TIGR01835; EC 2.3.3.10; HMM-score: 593.3)
    and 3 more
    hydroxymethylglutaryl-CoA synthase (TIGR01833; EC 2.3.3.10; HMM-score: 137)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis putative hydroxymethylglutaryl-CoA synthase (TIGR00748; EC 2.3.3.10; HMM-score: 88.6)
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis 3-oxoacyl-[acyl-carrier-protein] synthase III (TIGR00747; EC 2.3.1.180; HMM-score: 41.8)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Thiolase (CL0046) HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal (PF08540; HMM-score: 83.4)
    and 5 more
    HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal (PF01154; HMM-score: 44.4)
    Chal_sti_synt_N; Chalcone and stilbene synthases, N-terminal domain (PF00195; HMM-score: 30.6)
    ACP_syn_III; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III (PF08545; HMM-score: 20.8)
    ACP_syn_III_C; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal (PF08541; HMM-score: 18.3)
    Amidohydrolase (CL0034) CpsB_CapC; Capsular polysaccharide synthesis, CpsB/CapC (PF19567; HMM-score: 12.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9481
    • Cytoplasmic Membrane Score: 0.0101
    • Cell wall & surface Score: 0.0011
    • Extracellular Score: 0.0407
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00632
    • TAT(Tat/SPI): 0.001073
    • LIPO(Sec/SPII): 0.000532
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ARD36002 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNDKTEVNMTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSIAPLTEDIVTLAASASDSILTEQERQEVDMVIVATESGIDQSKAAAVFVHGLLGIQPFARSFEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAMLITQNPRMMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQKRYQLTLDDFAAVCFHLPYPKLALKGLKKIMDKSLPQEKKDLLQKHFDQSILYSQKVGNIYTGSLFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLNKLNQRTALSVADYEKVFFEEVNLDETNSAQFAGYENQDFALVEILDHQRRYSKVEK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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