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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 03-APR-2017

Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu15
  • locus tag: SPNHU15_00935 [new locus tag: SPNHU15_RS10920 ]
  • pan locus tag?: PNEUPAN000084000
  • symbol: SPNHU15_00935
  • pan gene symbol?:
  • synonym:
  • product: Type I restriction-modification system, specificity subunit S

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU15_00935 [new locus tag: SPNHU15_RS10920 ]
  • symbol: SPNHU15_00935
  • product: Type I restriction-modification system, specificity subunit S
  • replicon: chromosome
  • strand: +
  • coordinates: 881528..881725
  • length: 198
  • essential: unknown

Accession numbers[edit | edit source]

  • Location: CP020551 (881528..881725) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    GTGATATCAGGAAGTGCTCAGCCTCAGTTACCAATTACAAAATTAAAAAAAATACTTCTC
    CCCCTCCCCCCACTAGCCCTCCAAAATGAGTTCGCAGACTTTGTAGTCCAGGTCGACAAA
    TCTAAATTGGCAATCCAAAAATCTCTGGAAGAACTTGAAACTTTGAAGAAATCTCTGATG
    CAGGAGTATTTTGGCTGA
    60
    120
    180
    198

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SPNHU15_00935 [new locus tag: SPNHU15_RS10920 ]
  • symbol: SPNHU15_00935
  • description: Type I restriction-modification system, specificity subunit S
  • length: 65
  • theoretical pI: 9.09262
  • theoretical MW: 7298.64
  • GRAVY: -0.00153846

Function[edit | edit source]

  • reaction:
    EC 3.1.21.3?  ExPASy
    Type I site-specific deoxyribonuclease Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed
  • TIGRFAM:
    Metabolism Energy metabolism TCA cycle fumarate hydratase, class II (TIGR00979; EC 4.2.1.2; HMM-score: 14.6)
  • TheSEED: data available for TIGR4
  • PFAM:
    TRD (CL0477) Methylase_S; Type I restriction modification DNA specificity domain (PF01420; HMM-score: 28)
    and 1 more
    RNase_H (CL0219) RT_RNaseH_2; RNase H-like domain found in reverse transcriptase (PF17919; HMM-score: 13.2)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Extracellular
    • Cytoplasmic Score: 0.4107
    • Cytoplasmic Membrane Score: 0.0296
    • Cell wall & surface Score: 0.0016
    • Extracellular Score: 0.5581
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.010346
    • TAT(Tat/SPI): 0.000219
    • LIPO(Sec/SPII): 0.001594
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ARD36726 NCBI
  • UniProt:

Protein sequence[edit | edit source]

  • MISGSAQPQLPITKLKKILLPLPPLALQNEFADFVVQVDKSKLAIQKSLEELETLKKSLMQEYFG

Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription[edit | edit source]

  • transcription start site:

Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]