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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu15
  • locus tag: SPNHU15_RS00730 [old locus tag: SPNHU15_00148 ]
  • pan locus tag?: PNEUPAN003112000
  • symbol: nanA
  • pan gene symbol?: nanA
  • synonym:
  • product: LPXTG-anchored neuraminidase NanA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU15_RS00730 [old locus tag: SPNHU15_00148 ]
  • symbol: nanA
  • product: LPXTG-anchored neuraminidase NanA
  • replicon: chromosome
  • strand: -
  • coordinates: 142201..145098
  • length: 2898
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020551 (142201..145098) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1504 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    ATGAATCGGAGTGTTCAAGAACGTAAGTGTCGTTATAGCATTAGGAAACTATCGGTAGGA
    GCGGTTTCTATGATTGTAGGAGCAGTGGTATTTGGAACGTCTCCTGTTTTAGCTCAAGAA
    GGGGCAAGTGAGCAACCTCTGGCAAATGAAACTCAACTTTCGGGGGAGAGCTCAACCCTA
    ACTGATACAGAAAAGAGCCAGCCTTCTTCAGAGACTGAACTTTCTGGCAATAAGCAAGAA
    CAAGAAAGGAAAGATAAGCAAGAAGAAAAAATTCCAAGAGATTACTATGCACGAGATTTG
    GAAAATGTCGAAACAGTGATAGAAAAAGAAGATGTTGAAACCAATGCTTCAAATGGTCAG
    AGAGTTGATTTATCAAGTGAACTAGATAAACTAAAGAAACTTGAAAACGCAACAGTTCAC
    ATGGAGTTTAAGCCAGATGCCAAGGCCCCAGCATTCTATAATCTCTTTTCTGTGTCAAGT
    GCTACTAAAAAAGATGAGTACTTCACTATGGCAGTTTACAATAATACTGCTACTCTAGAG
    GGGCGTGGTTCGGATGGGAAACAGTTTTACAATAATTACAACGATGCACCCTTAAAAGTT
    AAACCAGGTCAGTGGAATTCTGTGACTTTCACAGTTGAAAAACCGACAGCAGAACTACCT
    AAAGGCCGAGTGCGCCTCTACGTAAACGGGGTATTATCTCGAACAAGTCTGAGATCTGGC
    AATTTCATTAAAGATATGCCAGATGTAACGCATGTGCAAATCGGAGCAACCAAGCGTGCC
    AACAATACGGTTTGGGGGTCAAATCTACAGATTCGGAATCTCACTGTGTATAATCGTGCT
    TTAACACCAGAAGAGGTACAAAAACGTAGTCAACTTTTTAAACGCTCAGATTTAGAAAAA
    AAACTACCTGAAGGAGCGGCTTTAACAGAGAAAACGGACATATTCGAAAGCGGGCGTAAC
    GGTAAACCAAATAAAGATGGAATCAAGAGTTATCGTATTCCAGCACTTCTCAAGACAGAT
    AAAGGAACTTTGATCGCAGGTGCAGATGAACGCCGTCTCCATTCGAGTGACTGGGGTGAT
    ATCGGTATGGTCATCAGACGTAGTGAAGATAATGGTAAAACTTGGGGTGACCGAGTAACC
    ATTACCAACTTACGTGACAATCCAAAAGCTTCTGACCCATCGATCGGTTCACCAGTGAAT
    ATCGATATGGTGTTGGTTCAAGATCCTGAAACCAAACGAATCTTTTCTATCTATGACATG
    TTCCCAGAAGGGAAGGGAATCTTTGGAATGTCTTCACAAAAAGAAGAAGCCTACAAAAAA
    ATCGATGGAAAAACCTATCAAATCCTCTATCGTGAAGGAGAAAAGGGAGCTTATACCATT
    CGAGAAAATGGTACTGTCTATACACCAGATGGTAAGGCGACAGACTATCGCGTTGTTGTA
    GATCCTGTTAAACCAGCCTATAGCGACAAGGGTGATCTATACAAGGGTAACCAATTACTA
    GGCAATATCTACTTCACAACAAACAAAACTTCTCCATTTAGAATTGCCAAGGATAGCTAT
    CTATGGATGTCCTACAGTGATGACGACGGGAAGACATGGTCAGCGCCTCAAGATATTACT
    CCGATGGTCAAAGCCGATTGGATGAAATTCTTGGGTGTAGGTCCTGGAACAGGAATTGTA
    CTTCGGAATGGGCCTCACAAGGGACGGATTTTGATACCGGTTTATACGACTAATAATGTA
    TCTCACTTAAATGGCTCGCAATCTTCTCGTGTCATCTATTCAGATGATCATGGAAAAACT
    TGGCATGCTGGAGAAGCGGTCAACGATAACCGCCAGGTAGACGGTCAAAAGATCCACTCT
    TCTACGATGAACAATAGACGTGCGCAAAATACAGAATCAACGGTGGTACAACTAAACAAT
    GGAGATGTTAAACTCTTTATGCGTGGTTTGACTGGAGATCTTCAGGTTGCTACAAGTAAA
    GACGGAGGAGTGACTTGGGAGAAGGATATCAAACGTTATCCACAGGTTAAAGATGTCTAT
    GTTCAAATGTCTGCTATCCATACGATGCATAATGGAAAAGAATACATTATCCTCAGCAAT
    GCAGGTGGACCGAATCGTGAAAATGGGATGGTCCACTTGGCACGTGTCGAAGAAAATGGT
    GAGTTGACTTGGCTCAAACACAATCCAATTCAAAAAGGAGAGTTTGCCTATAATTCGCTC
    CAAGAATTAGGAAATGGGGAGTATGGCATCTTGTATGAACATACTGAAAAAGGACAAAAT
    GCCTATACCCTATCATTTAGAAAATTTAATTGGGAATTTTTGAGCAAAGATCTGATTTCT
    CCTACCGAAGCGAAAGTGAAGCGAACTAGAGAGATGGGCAAAGGAGAGATGGGCAAAGGA
    GTTATTGGCTTGGAGTTTGACTCAGAAGTATTGGTCAACAAGGCTCCAACCCTTCAATTG
    GCAAATGGTAAAACAGCGACTTTCCTAACCCAGTATGATAGCAAGACCTTGTTGTTTGCA
    GTAGATAAGGAAGATATCGGACAGGAAATTATTGGTATAGCTAAAGGAAGCATCGAAAGT
    ATGCATAATCTTCCTGTAAATCTAGCAGGTGCCAGAGTTCCTGGCGGAGTAAATGGTAGC
    AAAGCAGCGGTGCATGAAGTTCCAGAATTTACAGGGGGAGTTAATGGTACAGAGCCAGCT
    GTTCATGAAATCGCAGAGTATAAGGGATCTGATTCGCTTGTAACTCTTACTACAAAAGAA
    GATTATACTTACAAAGCTCCTCTTGCTCAGCAGGCACTTCCTGAAACAGGAAACAAGGAG
    AGTGACCTCCTAGCTTCACTAGGACTAACAGCTTTCTTCCTTGGTCTGTTTACGCTAGGG
    AAAAAGAGAGAACAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2898

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU15_RS00730 [old locus tag: SPNHU15_00148 ]
  • symbol: NanA
  • description: LPXTG-anchored neuraminidase NanA
  • length: 965
  • theoretical pI: 7.87699
  • theoretical MW: 107128
  • GRAVY: -0.64829

⊟Function[edit | edit source]

  • reaction:
    EC 3.2.1.18?  ExPASy
    Exo-alpha-sialidase Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates
  • TIGRFAM:
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 52.7)
    and 1 more
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 16.9)
  • TheSEED: data available for D39, Hungary19A-6
  • PFAM:
    Concanavalin (CL0004) Sialidase; Sialidase, N-terminal domain (PF02973; HMM-score: 285.6)
    and 11 more
    Sialidase (CL0434) BNR_2; BNR repeat-like domain (PF13088; HMM-score: 78.9)
    Concanavalin (CL0004) Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily (PF13385; HMM-score: 53.1)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 42.7)
    Sialidase (CL0434) BNR_3; BNR repeat-like domain (PF13859; HMM-score: 40.9)
    BNR; BNR/Asp-box repeat (PF02012; HMM-score: 35.7)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 17.8)
    E-set (CL0159) CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain (PF03174; HMM-score: 14.2)
    HAD (CL0137) PGP_phosphatase; Mitochondrial PGP phosphatase (PF09419; HMM-score: 12.6)
    Sialidase (CL0434) Sortilin-Vps10; Sortilin, neurotensin receptor 3, (PF15902; HMM-score: 12.6)
    no clan defined Epiglycanin_TR; Tandem-repeating region of mucin, epiglycanin-like (PF05647; HMM-score: 11.9)
    GT-C (CL0111) YfhO; Bacterial membrane protein YfhO (PF09586; HMM-score: 6.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0002
    • Cytoplasmic Membrane Score: 0.0501
    • Cell wall & surface Score: 0.7976
    • Extracellular Score: 0.1521
  • SignalP: Signal peptide SP(Sec/SPI) length 38 aa
    • SP(Sec/SPI): 0.987957
    • TAT(Tat/SPI): 0.008977
    • LIPO(Sec/SPII): 0.001051
    • Cleavage Site: CS pos: 38-39. VLA-QE. Pr: 0.9559
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_129559156 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASEQPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLENVETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSSATKKDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTAELPKGRVRLYVNGVLSRTSLRSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTVYNRALTPEEVQKRSQLFKRSDLEKKLPEGAALTEKTDIFESGRNGKPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASDPSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYREGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGNQLLGNIYFTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRVIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHNGKEYIILSNAGGPNRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWEFLSKDLISPTEAKVKRTREMGKGEMGKGVIGLEFDSEVLVNKAPTLQLANGKTATFLTQYDSKTLLFAVDKEDIGQEIIGIAKGSIESMHNLPVNLAGARVPGGVNGSKAAVHEVPEFTGGVNGTEPAVHEIAEYKGSDSLVTLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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