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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu15
  • locus tag: SPNHU15_RS04280 [old locus tag: SPNHU15_00915 ]
  • pan locus tag?: PNEUPAN001820000
  • symbol: SPNHU15_RS04280
  • pan gene symbol?: sufS
  • synonym:
  • product: cysteine desulfurase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU15_RS04280 [old locus tag: SPNHU15_00915 ]
  • symbol: SPNHU15_RS04280
  • product: cysteine desulfurase
  • replicon: chromosome
  • strand: +
  • coordinates: 859043..860269
  • length: 1227
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020551 (859043..860269) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0764 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGTTAGATGTAGAAGCGATTCGCAAGGATTTTCCAATTTTAGATCAGATTGTCAATGAT
    GAACCTCTGGTCTATCTGGACAATGCTGCGACGACACAAAAACCACTAGTAGTTCTGAAA
    GCTATTAACAGTTACTATGAGCAGGACAATGCCAATGTTCACCGTGGTGTCCATACCTTA
    GCGGAACGAGCGACAGCTTCTTATGAAGCTGCTCGTGAAACCATTCGTAAGTTTATTAAT
    GCAGGCTCTACAAAGGAAGTTCTCTTTACCAGAGGAACGACAACCAGCCTTAACTGGGTG
    GCACGCTTTGCTGAGGAAATTCTCGCTGAGGGAGACCGGGTCTTGATTTCAGTAATGGAA
    CACCATTCTAATATCATTCCATGGCAGGAAGCTTGTCGAAAGACTGGAGCAGAGCTTGTC
    TATGTCTATCTTAAAGACGGTGCCTTGGATATGGAGGATTTGCGAGCTAAATTGACTGAT
    AAGGTTAAATTTGTTTCCCTAGCTCATGCCTCCAATGTTCTTGGTGTGGTCAATCCGATC
    AAGGAAATCACTCAATTAGCCCACCAAGTTGGGGCAATTATGGTAGTGGATGGTGCTCAA
    TCTACACCTCATATGAAGATTGATGTCCAGGACTTGGATCTGGACTTTTTCGCCTTTTCG
    GGTCACAAGATGGCTGGTCCGACTGGTATCGGTGTCCTTTACGGCAAAGAAAAGTATCTT
    GAGCAAATGTCTCCAGTAGAATTTGGCGGCGAGATGATTGATTTTGTCTACGAGCAATTT
    GCTAGTTGGAAGGAATTGCCTTGGAAATTTGAGGCTGGAACGCCAAATATGGCAGGAGCT
    ATTGGACTTGCGACTGCAGTTGATTATCTGGAAAAGATTGGTATGGATGCCGTTGAAGCT
    CATGAACAGGAATTGATTGCGTACGTCTATCCAAAACTGCAGGCAATTGAGGGATTGACC
    ATTTACGGTTCTCAGGATTTGGCTCAACGTTCGGGTGTTATTGCCTTTAACCTAGGTGAT
    CTCCATCCTCACGATCTTGCGACGGCTCTGGATTATGAAGGAGTGGCTGTTCGTGCTGGT
    CACCATTGTGCGCAACCCTTGCTTCAGTATTTGGAAGTCCCAGCAACAGCTCGTGCAAGT
    TTTTATATCTACAATACCAAGGCAGATTGCGACAAACTAGTCGATGCCCTACAAAAGACA
    AAGGAGTTTTTCAATGGCACTTTCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1227

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU15_RS04280 [old locus tag: SPNHU15_00915 ]
  • symbol: SPNHU15_RS04280
  • description: cysteine desulfurase
  • length: 408
  • theoretical pI: 4.8447
  • theoretical MW: 45222.2
  • GRAVY: -0.0791667

⊟Function[edit | edit source]

  • reaction:
    EC 2.8.1.7?  ExPASy
    Cysteine desulfurase L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase, SufS family (TIGR01979; HMM-score: 599.7)
    and 28 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase, catalytic subunit CsdA (TIGR03392; EC 2.8.1.7; HMM-score: 383.8)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 267.6)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01976; HMM-score: 254.7)
    cysteine desulfurase NifS (TIGR03402; EC 2.8.1.7; HMM-score: 156.7)
    Genetic information processing Protein synthesis tRNA and rRNA base modification cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 126.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 126.8)
    Genetic information processing DNA metabolism Restriction/modification cysteine desulfurase DndA (TIGR03235; EC 2.8.1.7; HMM-score: 122.8)
    cysteine desulfurase, NifS family (TIGR03403; EC 2.8.1.7; HMM-score: 117.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs ergothioneine biosynthesis PLP-dependent enzyme EgtE (TIGR04343; EC 4.4.-.-; HMM-score: 76.2)
    2-aminoethylphosphonate aminotransferase (TIGR03301; EC 2.6.1.-; HMM-score: 41.6)
    Metabolism Central intermediary metabolism Phosphorus compounds 2-aminoethylphosphonate--pyruvate transaminase (TIGR02326; EC 2.6.1.37; HMM-score: 40)
    Metabolism Amino acid biosynthesis Aspartate family O-succinylhomoserine sulfhydrylase (TIGR01325; EC 4.2.99.-; HMM-score: 33.6)
    O-phospho-L-seryl-tRNA:Cys-tRNA synthase (TIGR02539; EC 2.5.1.73; HMM-score: 30.9)
    Cellular processes Cellular processes Biosynthesis of natural products capreomycidine synthase (TIGR03947; HMM-score: 23.9)
    Metabolism Amino acid biosynthesis Aspartate family O-succinylhomoserine (thiol)-lyase (TIGR02080; EC 2.5.1.48; HMM-score: 22.1)
    putative pyridoxal phosphate-dependent acyltransferase (TIGR01825; EC 2.3.1.-; HMM-score: 17.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other tyrosine decarboxylase MnfA (TIGR03812; EC 4.1.1.25; HMM-score: 17.3)
    Metabolism Amino acid biosynthesis Histidine family histidinol-phosphate transaminase (TIGR01141; EC 2.6.1.9; HMM-score: 16.9)
    Metabolism Energy metabolism Amino acids and amines glycine C-acetyltransferase (TIGR01822; EC 2.3.1.29; HMM-score: 15.6)
    Metabolism Energy metabolism Amino acids and amines methionine gamma-lyase (TIGR01328; EC 4.4.1.11; HMM-score: 15.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin 8-amino-7-oxononanoate synthase (TIGR00858; EC 2.3.1.47; HMM-score: 12.9)
    Metabolism Amino acid biosynthesis Aspartate family O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase (TIGR01326; HMM-score: 12.7)
    Metabolism Amino acid biosynthesis Serine family O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase (TIGR01326; HMM-score: 12.7)
    Unknown function Enzymes of unknown specificity probable F420-dependent oxidoreductase, MSMEG_3544 family (TIGR03854; HMM-score: 12.7)
    Metabolism Energy metabolism Amino acids and amines glycine dehydrogenase (TIGR00461; EC 1.4.4.2; HMM-score: 12.2)
    Genetic information processing Protein synthesis tRNA aminoacylation L-seryl-tRNA(Sec) selenium transferase (TIGR00474; EC 2.9.1.1; HMM-score: 12)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin 5-aminolevulinic acid synthase (TIGR01821; EC 2.3.1.37; HMM-score: 11.4)
    putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 11.2)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 500.5)
    and 4 more
    Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 45.9)
    Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 28.6)
    Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 23.8)
    DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 17.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9976
    • Cytoplasmic Membrane Score: 0.0004
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0019
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001811
    • TAT(Tat/SPI): 0.000175
    • LIPO(Sec/SPII): 0.000291
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000887721 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINSYYEQDNANVHRGVHTLAERATASYEAARETIRKFINAGSTKEVLFTRGTTTSLNWVARFAEEILAEGDRVLISVMEHHSNIIPWQEACRKTGAELVYVYLKDGALDMEDLRAKLTDKVKFVSLAHASNVLGVVNPIKEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFAFSGHKMAGPTGIGVLYGKEKYLEQMSPVEFGGEMIDFVYEQFASWKELPWKFEAGTPNMAGAIGLATAVDYLEKIGMDAVEAHEQELIAYVYPKLQAIEGLTIYGSQDLAQRSGVIAFNLGDLHPHDLATALDYEGVAVRAGHHCAQPLLQYLEVPATARASFYIYNTKADCDKLVDALQKTKEFFNGTF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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