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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu17
  • locus tag: SPNHU17_RS03645 [old locus tag: SPNHU17_00795 ]
  • pan locus tag?: PNEUPAN001718000
  • symbol: SPNHU17_RS03645
  • pan gene symbol?: —
  • synonym:
  • product: NAD(P)/FAD-dependent oxidoreductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU17_RS03645 [old locus tag: SPNHU17_00795 ]
  • symbol: SPNHU17_RS03645
  • product: NAD(P)/FAD-dependent oxidoreductase
  • replicon: chromosome
  • strand: -
  • coordinates: 733339..734511
  • length: 1173
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020549 (733339..734511) NCBI
  • BioCyc: SPNHU17_RS03645 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0645 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGAAACATTTTGATACTATTGTCATCGGTGGGGGACCTGCTGGTATGATGGCTACGATT
    TCCAGTAGCTTTTATGGACAGAAAACCCTCCTCATCGAAAAAAATCGGAAACTTGGAAAA
    AAATTAGCTGGGACTGGTGGGGGACGTTGCAATGTGACCAACAATGGTAGCTTAGACAAC
    CTGCTAGCTGGAATTCCTGGAAACGGACGCTTTCTTTACAGTGTTTTCTCCCAGTTCGAT
    AATCATGACATCATCAACTTTTTTACAGAAAATGGTGTTAAACTTAAGGTCGAAGACCAC
    GGACGCGTCTTTCCAGCCAGTGACAAGTCTCGGACTATTATCGAAGCTTTGGAAAAGAAA
    ATCACTGAACTAGGTGGTCAAGTTGCTACTCAAATAGAAATCGTTTCTGTTAAAAAAGTA
    GATGACCAGTTTGTCCTTAAGTCAGCAGATCAAACCTTCACTTGTGAGAAACTCATTGTC
    ACAACAGGTGGTAAGTCTTATCCTTCGACTGGTTCGACTGGTTTTGGTCACGAGATTGCT
    CGCCATTTTAAGCATACCATCACCGAGCTTGAGGCTGCTGAAAGTCCTTTATTAACAGAT
    TTTCCACATAAAGCCTTACAAGGGATTTCTTTGGACGATGTGACCCTAAGTTATGGTAAG
    CATGTCATCACTCATGATTTACTCTTTACCCACTTTGGTTTGTCAGGTCCTGCTGCCCTA
    CGCATGTCTAGCTTTGTCAAAGGTGGGGAGGTTCTCTCACTCGATGTTTTGCCTCAACTT
    TCTGAGAAGGACTTGGTTACATTTCTAGAAGAAAATCGGGAAAAATCCTTGAAAAACGCT
    TTAAAAACCTTGTTACCAGAACGCTTGGCCGAATTTTTTGTACAAGGATATCCTGAAAAA
    GTCAAACAGCTGACTGAAAAGGAACGAGAACAACTTGTCCAGTCCATTAAAGAACTTAAA
    ATTCCTGTAACTGGAAAAATGTCCCTTGCAAAGTCCTTTGTTACCAAGGGTGGAGTCAGT
    CTCAAGGAAATCAATCCTAAAACCCTTGAAAGTAAGCTGGTACCTGGCCTCCACTTTGCA
    GGCGAAGTTATGGATATCAATGCCCACACGGGTGGCTTTAACATCACTTCTGCTCTCTGT
    ACCGGCTGGGTGGCGGGATCAAATCCAATCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1173

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU17_RS03645 [old locus tag: SPNHU17_00795 ]
  • symbol: SPNHU17_RS03645
  • description: NAD(P)/FAD-dependent oxidoreductase
  • length: 390
  • theoretical pI: 8.46266
  • theoretical MW: 42405.4
  • GRAVY: -0.143333

⊟Function[edit | edit source]

  • reaction:
    EC 1.14.13.-?  ExPASy
  • TIGRFAM:
    Unknown function Enzymes of unknown specificity flavoprotein, HI0933 family (TIGR00275; HMM-score: 445.3)
    and 33 more
    flavoprotein, TIGR03862 family (TIGR03862; HMM-score: 115.5)
    dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 36.3)
    Metabolism Energy metabolism Electron transport thioredoxin-disulfide reductase (TIGR01292; EC 1.8.1.9; HMM-score: 34.5)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, monomeric form (TIGR01377; HMM-score: 29)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase family (TIGR02032; EC 1.3.1.-; HMM-score: 24.4)
    Unknown function Enzymes of unknown specificity putative bacillithiol system oxidoreductase, YpdA family (TIGR04018; EC 1.8.-.-; HMM-score: 23)
    squalene-associated FAD-dependent desaturase (TIGR03467; HMM-score: 22.5)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA (TIGR00136; HMM-score: 20.4)
    mycofactocin system FadH/OYE family oxidoreductase 2 (TIGR03997; EC 1.-.-.-; HMM-score: 19.4)
    Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01421; EC 1.8.1.7; HMM-score: 18.5)
    putative alkyl hydroperoxide reductase F subunit (TIGR03143; EC 1.6.4.-; HMM-score: 18.4)
    Metabolism Energy metabolism Anaerobic glycerol-3-phosphate dehydrogenase, anaerobic, B subunit (TIGR03378; EC 1.1.5.3; HMM-score: 18.2)
    flavin-dependent oxidoreductase, MSMEG_0569 family (TIGR04046; HMM-score: 18.1)
    Cellular processes Cellular processes Detoxification alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 17.9)
    Cellular processes Cellular processes Adaptations to atypical conditions alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 17.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine glycine oxidase ThiO (TIGR02352; EC 1.4.3.19; HMM-score: 17.3)
    thioredoxin and glutathione reductase (TIGR01438; EC 1.6.4.-; HMM-score: 17.2)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, alpha subunit family (TIGR01372; HMM-score: 16.7)
    Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01424; EC 1.8.1.7; HMM-score: 14.6)
    mycofactocin system FadH/OYE family oxidoreductase 1 (TIGR03996; EC 1.-.-.-; HMM-score: 13.4)
    Cellular processes Cellular processes Detoxification mercury(II) reductase (TIGR02053; EC 1.16.1.1; HMM-score: 12.7)
    Metabolism Energy metabolism TCA cycle succinate dehydrogenase, flavoprotein subunit (TIGR01816; HMM-score: 12.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase (TIGR02023; EC 1.3.1.-; HMM-score: 11.9)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain (TIGR03197; HMM-score: 11.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family (TIGR01988; EC 1.14.13.-; HMM-score: 11.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other phytoene desaturase (TIGR02734; EC 1.14.99.-; HMM-score: 11.6)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-galactopyranose mutase (TIGR00031; EC 5.4.99.9; HMM-score: 11.3)
    lycopene cyclase family protein (TIGR01790; HMM-score: 10.9)
    Metabolism Energy metabolism TCA cycle succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 10.8)
    Metabolism Energy metabolism Anaerobic succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 10.8)
    Metabolism Energy metabolism Aerobic succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 10.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase (TIGR02028; HMM-score: 10.1)
    Metabolism Energy metabolism Electron transport flavocytochrome c (TIGR01813; HMM-score: 9.5)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    NADP_Rossmann (CL0063) HI0933_like; HI0933-like protein (PF03486; HMM-score: 465.1)
    and 10 more
    GIDA; Glucose inhibited division protein A (PF01134; HMM-score: 34.8)
    FAD_binding_2; FAD binding domain (PF00890; HMM-score: 34.6)
    Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase (PF13738; HMM-score: 33.3)
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 29.5)
    FAD_oxidored; FAD dependent oxidoreductase (PF12831; HMM-score: 28.5)
    DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 20.6)
    FAD_binding_3; FAD binding domain (PF01494; HMM-score: 19.7)
    NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 16.2)
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 15.9)
    TPR (CL0020) TRF; Telomere repeat binding factor (TRF) (PF08558; HMM-score: 13.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helix: 1
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.082223
    • TAT(Tat/SPI): 0.008441
    • LIPO(Sec/SPII): 0.051947
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000680058 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAGTGGGRCNVTNNGSLDNLLAGIPGNGRFLYSVFSQFDNHDIINFFTENGVKLKVEDHGRVFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQFVLKSADQTFTCEKLIVTTGGKSYPSTGSTGFGHEIARHFKHTITELEAAESPLLTDFPHKALQGISLDDVTLSYGKHVITHDLLFTHFGLSGPAALRMSSFVKGGEVLSLDVLPQLSEKDLVTFLEENREKSLKNALKTLLPERLAEFFVQGYPEKVKQLTEKEREQLVQSIKELKIPVTGKMSLAKSFVTKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTGWVAGSNPI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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