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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-AUG-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu17
  • locus tag: SPNHU17_RS06450 [old locus tag: SPNHU17_01383 ]
  • pan locus tag?: PNEUPAN000230000
  • symbol: SPNHU17_RS06450
  • pan gene symbol?: ntpA
  • synonym:
  • product: V-type ATP synthase subunit A

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU17_RS06450 [old locus tag: SPNHU17_01383 ]
  • symbol: SPNHU17_RS06450
  • product: V-type ATP synthase subunit A
  • replicon: chromosome
  • strand: -
  • coordinates: 1283730..1285505
  • length: 1776
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020549 (1283730..1285505) NCBI
  • BioCyc: SPNHU17_RS06450 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    TTGACTCAAGGGAAGATTATAAAAGTATCGGGACCTCTAGTTATTGCATCAGGTATGCAG
    GAGGCTAATATTCAAGATATTTGCCGTGTAGGTAAGCTAGGGTTAATCGGTGAAATTATT
    GAAATGAGAAGAGATCAGGCATCTATCCAAGTCTATGAAGAAACATCTGGTCTTGGTCCG
    GGAGAACCTGTTGTTACAACTGGAGAACCTCTCTCGGTTGAATTAGGGCCTGGATTGATT
    TCTCAAATGTTTGATGGCATACAACGCCCATTAGATCGATTTAAATTGGCTACTCATAAT
    GATTTTCTAGTTCGTGGGGTAGAAGTTCCAAGTTTGGATAGAGATATTAAGTGGCATTTT
    GATTCCACTATATCAATTGGTCAAAAAGTGAGTACGGGTGATATTCTTGGAACTGTCAAG
    GAAACCGAAGTAGTTAATCATAAAATTATGGTTCCTTATGGAATATCTGGCGAAGTCGTT
    TCTATTGCCTCTGGCGATTTTACAATTGATGAAGTTGTATATGAAATAAAAAAATTGGAC
    GGTAGTTTCTATAAAGGAACACTTATGCAAAAATGGCCTGTCCGCAAGGCGCGTCCTGTT
    TCTAAACGTTTAATCCCAGAAGAACCATTAATCACAGGTCAACGAGTTATTGATACATTC
    TTTCCAGTAACCAAAGGGGGAGCAGCAGCTGTTCCTGGACCGTTTGGAGCAGGAAAGACA
    GTTGTACAACACCAAGTAGCTAAATTTGCCAATGTTGATATTGTTATTTATGTCGGTTGT
    GGAGAACGTGGAAATGAAATGACGGATGTACTGAATGAGTTTCCTGAGTTGATTGACCCT
    AATACAGGACAATCAATTATGCAACGGACAGTTCTGATTGCTAATACTTCAAATATGCCT
    GTTGCTGCTCGTGAGGCTTCAATTTATACAGGAATTACCATGGCTGAGTATTTTCGTGAT
    ATGGGCTACTCTGTCGCCATTATGGCTGATTCGACTTCACGTTGGGCAGAAGCGCTACGT
    GAAATGTCAGGACGTCTAGAAGAAATGCCTGGTGATGAGGGTTATCCTGCTTATCTTGGA
    AGTCGTATCGCTGAATATTATGAAAGAGCGGGACGTTCTCAGGCTCTAGGGCTTCCAGAA
    CGTGAAGGAACGATTACTGCTATTGGAGCTGTATCGCCACCCGGTGGAGATATTTCAGAA
    CCAGTTACTCAAAACACTTTACGGATTGTGAAAGTTTTTTGGGGGCTTGATGCTCCGTTG
    GCACAGCGACGTCATTTTCCTGCAATTAACTGGCTTACCTCTTATTCACTCTATAAAGAC
    AGTGTGGGAACTTATATAGATGATAAAGAGAAGACAGATTGGAATAGTAAAATAACTCGT
    GCGATGAACTACTTACAACGGGAATCTAGTTTAGAGGAAATTGTTCGTCTTGTTGGAATT
    GATTCTCTGTCTGAAAATGAACGACTAACGATGGAAATTGCTAAACAAATTAGAGAAGAT
    TATTTGCAACAGAACGCTTTTGATTCGGTAGATACATTCACTTCGTTTGCAAAACAAGAA
    GCAATGTTAAGTAATATCCTAACTTTTGCTGATCAGGCAAATCATGCTTTAGAGTTGGGT
    TCTTACTTTACAGAGATTATAGAAGGTACCGTGGCAGTTCGAGACCGTATGGCGAGAAGT
    AAATATGTTTCAGAAGATAGATTAGATGAAATCAAAATTATTTCAAATGAGATTACACAT
    CAAATTCAATTGATATTAGAAACAGGAGGTCTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1776

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU17_RS06450 [old locus tag: SPNHU17_01383 ]
  • symbol: SPNHU17_RS06450
  • description: V-type ATP synthase subunit A
  • length: 591
  • theoretical pI: 4.7042
  • theoretical MW: 65355.9
  • GRAVY: -0.188663

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase archaeal, A subunit (TIGR01043; EC 3.6.3.14; HMM-score: 888.4)
    Metabolism Transport and binding proteins Cations and iron carrying compounds V-type ATPase, A subunit (TIGR01042; EC 3.6.3.14; HMM-score: 732.9)
    and 13 more
    Cellular processes Cellular processes Pathogenesis type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 178.4)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 178.4)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATPase, FliI/YscN family (TIGR01026; EC 3.6.3.14; HMM-score: 175.6)
    Cellular processes Cellular processes Chemotaxis and motility flagellar protein export ATPase FliI (TIGR03497; EC 3.6.3.14; HMM-score: 172.3)
    Cellular processes Cellular processes Chemotaxis and motility flagellar protein export ATPase FliI (TIGR03496; EC 3.6.3.14; HMM-score: 164.4)
    flagellar protein export ATPase FliI (TIGR03498; EC 3.6.3.14; HMM-score: 161.9)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F1, beta subunit (TIGR01039; EC 3.6.3.14; HMM-score: 129.7)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase archaeal, B subunit (TIGR01041; EC 3.6.3.14; HMM-score: 124.8)
    Metabolism Transport and binding proteins Cations and iron carrying compounds V-type ATPase, B subunit (TIGR01040; EC 3.6.3.14; HMM-score: 121)
    alternate F1F0 ATPase, F1 subunit beta (TIGR03305; EC 3.6.3.-; HMM-score: 114.1)
    Metabolism Energy metabolism ATP-proton motive force interconversion ATP synthase F1, alpha subunit (TIGR00962; EC 3.6.3.14; HMM-score: 88.9)
    alternate F1F0 ATPase, F1 subunit alpha (TIGR03324; EC 3.6.3.-; HMM-score: 83.2)
    Genetic information processing Transcription Transcription factors transcription termination factor Rho (TIGR00767; EC 3.6.4.-; HMM-score: 17.3)
  • TheSEED: data available for Hungary19A-6, TIGR4
  • PFAM:
    P-loop_NTPase (CL0023) ATP-synt_ab; ATP synthase alpha/beta family, nucleotide-binding domain (PF00006; HMM-score: 316.1)
    and 3 more
    no clan defined ATP-synt_ab_Xtn; ATPsynthase alpha/beta subunit N-term extension (PF16886; HMM-score: 141.5)
    HAS-barrel (CL0275) ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain (PF02874; HMM-score: 42)
    P-loop_NTPase (CL0023) AAA_22; AAA domain (PF13401; HMM-score: 14.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.022366
    • TAT(Tat/SPI): 0.000797
    • LIPO(Sec/SPII): 0.007654
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000191788 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTQGKIIKVSGPLVIASGMQEANIQDICRVGKLGLIGEIIEMRRDQASIQVYEETSGLGPGEPVVTTGEPLSVELGPGLISQMFDGIQRPLDRFKLATHNDFLVRGVEVPSLDRDIKWHFDSTISIGQKVSTGDILGTVKETEVVNHKIMVPYGISGEVVSIASGDFTIDEVVYEIKKLDGSFYKGTLMQKWPVRKARPVSKRLIPEEPLITGQRVIDTFFPVTKGGAAAVPGPFGAGKTVVQHQVAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMQRTVLIANTSNMPVAAREASIYTGITMAEYFRDMGYSVAIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGSRIAEYYERAGRSQALGLPEREGTITAIGAVSPPGGDISEPVTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYKDSVGTYIDDKEKTDWNSKITRAMNYLQRESSLEEIVRLVGIDSLSENERLTMEIAKQIREDYLQQNAFDSVDTFTSFAKQEAMLSNILTFADQANHALELGSYFTEIIEGTVAVRDRMARSKYVSEDRLDEIKIISNEITHQIQLILETGGL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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