PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 11-FEB-2025

⊟Summary

• organism: Streptococcus pneumoniae INV200
• locus tag: SPNINV200_RS09545 [old locus tag: SPNINV200_17800 ]
• pan locus tag^?: PNEUPAN003586000
• symbol: coaD
• pan gene symbol^?: coaD
• synonym:
• product: pantetheine-phosphate adenylyltransferase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNINV200_RS09545 [old locus tag: SPNINV200_17800 ]
• symbol: coaD
• product: pantetheine-phosphate adenylyltransferase
• replicon: chromosome
• strand: -
• coordinates: 1807207..1807695
• length: 489
• essential: unknown other strains

⊟Accession numbers

• Location: NC_017593 (1807207..1807695) NCBI
• BioCyc: SPNINV200_RS09545 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1766 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  
  ATGTCAGATAAGATTGGCTTATTCACAGGCTCATTTGATCCGATGACAAATGGGCATCTG
  GATATGATTGAACGGGCGAGCAGACTCTTTGATAAGCTTTATGTGGGTATTTTTTTTAAT
  CCCCACAAACAAGGATTTCTCCCTCTTGAAAATCGTAAACGGGGGTTAGAAAAGGCTGTG
  AAACATTTGGGAAATGTTAAAGTCGTGTCTTCTCATGATAAATTGGTGGTCGATGTCGCA
  AAAAGACTGGGGGCTACTTGCCTAGTGCGAGGCTTGAGAAATGCGTCGGATTTGCAATAT
  GAAGCCAGTTTTGATTACTACAATCATCAGCTGTCTTCTGATATAGAGACTATTTATTTA
  CATAGTCGACCTGAACATCTCTATATCAGTTCATCAGGCGTTAGAGAGCTTTTGAAGTTT
  GGTCAGGATATTGCCTGCTATGTTCCCGAGAGTATTTTGGAGGAAATAAGAAATGAAAAA
  AAAGATTAG
  60
  120
  180
  240
  300
  360
  420
  480
  489
  

⊟Protein

⊟General

• locus tag: SPNINV200_RS09545 [old locus tag: SPNINV200_17800 ]
• symbol: CoaD
• description: pantetheine-phosphate adenylyltransferase
• length: 162
• theoretical pI: 7.69836
• theoretical MW: 18488
• GRAVY: -0.374074

⊟Function

• reaction:
  EC 2.7.7.3?  ExPASy
  Pantetheine-phosphate adenylyltransferase ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
• TIGRFAM:
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A pantetheine-phosphate adenylyltransferase (TIGR01510; EC 2.7.7.3; HMM-score: 182.7)
  and 9 more
  cytidyltransferase-like domain (TIGR00125; HMM-score: 61.7)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides nicotinate (nicotinamide) nucleotide adenylyltransferase (TIGR00482; EC 2.7.7.18; HMM-score: 48.4)
  nicotinamide-nucleotide adenylyltransferase (TIGR01526; EC 2.7.7.1; HMM-score: 23.8)
  Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan glycerol-3-phosphate cytidylyltransferase (TIGR01518; EC 2.7.7.39; HMM-score: 20.6)
  Genetic information processing Protein fate Protein modification and repair [citrate (pro-3S)-lyase] ligase (TIGR00124; EC 6.2.1.22; HMM-score: 16.9)
  Metabolism Energy metabolism Fermentation [citrate (pro-3S)-lyase] ligase (TIGR00124; EC 6.2.1.22; HMM-score: 16.9)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides nicotinamide-nucleotide adenylyltransferase (TIGR01527; EC 2.7.7.1; HMM-score: 16)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides bifunctional protein RfaE, domain II (TIGR02199; EC 2.7.7.-; HMM-score: 15.5)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A pantoate--beta-alanine ligase (TIGR00018; EC 6.3.2.1; HMM-score: 13.4)
• TheSEED: see SPNINV200_17800
• PFAM:
  HUP (CL0039) CTP_transf_like; Cytidylyltransferase-like (PF01467; HMM-score: 57.1)
  and 3 more
  Citrate_ly_lig; Citrate lyase ligase C-terminal domain (PF08218; HMM-score: 27.8)
  Pantoate_ligase; Pantoate-beta-alanine ligase (PF02569; HMM-score: 13.8)
  ATP-sulfurylase; ATP-sulfurylase (PF01747; HMM-score: 12.2)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9703
  • Cytoplasmic Membrane Score: 0.0017
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0279
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.001332
  • TAT(Tat/SPI): 0.000212
  • LIPO(Sec/SPII): 0.000275
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_001280769 NCBI
• UniProt:

⊟Protein sequence

• MSDKIGLFTGSFDPMTNGHLDMIERASRLFDKLYVGIFFNPHKQGFLPLENRKRGLEKAVKHLGNVKVVSSHDKLVVDVAKRLGATCLVRGLRNASDLQYEASFDYYNHQLSSDIETIYLHSRPEHLYISSSGVRELLKFGQDIACYVPESILEEIRNEKKD

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1766 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications