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serotype 4
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serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
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ATCC 49619
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ATCC 700669
serotype 23F
BM6001
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BVJ1JL
serotype 1
CGSP14
serotype 14
G54
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HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 26-AUG-2017

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae OXC141
  • locus tag: SPNOXC18550 [new locus tag: SPNOXC_RS10290 ]
  • pan locus tag?: PNEUPAN003770000
  • symbol: SPNOXC18550
  • pan gene symbol?: rrmA
  • synonym:
  • product: putative ribosomal RNA large subunit methyltransferase A

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNOXC18550 [new locus tag: SPNOXC_RS10290 ]
  • symbol: SPNOXC18550
  • product: putative ribosomal RNA large subunit methyltransferase A
  • replicon: chromosome
  • strand: +
  • coordinates: 1892867..1893715
  • length: 849
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGAATACAAATCTCAAGCCCAAACTTCAGCGTTTTGCTTCTGCGACTGCCTTTGCCTGT
    CCTATCTGTCAAGAAAATCTGACTCTGTTAGAGACTAATTTCAAGTGCTGCAACCGTCAT
    TCTTTTGACTTGGCGAAATTTGGCTATGTCAATCTAGCACCTCAAATCAAGCAATCTGCT
    AACTATGACAAGGAAAATTTTCAAAACCGTCAACAAATCCTAGAAGCCGGCTTTTACCAA
    GCTATCTTAGATGCTGTATCTGACTTGCTTGCAAGCTCAAAAACTACCACAACAATTTTG
    GATATCGGTTGTGGTGAAGGATTCTATTCTCGCAAACTACAAGAAAGTCACTCTGAAAAA
    ACTTTCTATGCCTTTGACATCTCCAAAGATTCAGTCCAAATCGCTGCTAAAAGTGAACCC
    AACTGGGCAGTCAATTGGTTCGTTGGCGACTTGGCACGACTTCCTATAAAAGACGCTAAC
    ATGGATATTCTGCTTGATATCTTCTCACCTGCCAACTATGGAGAATTTCGTCGCGTTTTA
    TCCAAAGACGGTATCTTGATAAAGGTTATCCCAACTGAAAATCACCTCAAAGAAATCCGT
    CAAAGAGTACAGGACCAGCTGACAAACAAGGAGTATTCTAACCAAGATATCAAGGAGCAT
    TTCCAGGAACACTTTACCATCCTATCTAGTCAAACTGCCTCTCTGACTAAGACTATCACA
    GCAGAACAACTCCAAGCCCTACTCAGTATGACTCCTCTCCTCTTTCACGTTGACCAGAGC
    AAAATTGACTGGAGCAAACTGACAGAGATTACCATCGAAGCAGAGATTTTGGTTGGGAAA
    GCATTCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    849

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNOXC18550 [new locus tag: SPNOXC_RS10290 ]
  • symbol: SPNOXC18550
  • description: putative ribosomal RNA large subunit methyltransferase A
  • length: 282
  • theoretical pI: 6.25169
  • theoretical MW: 32026.2
  • GRAVY: -0.280851

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin malonyl-acyl carrier protein O-methyltransferase BioC (TIGR02072; EC 2.1.1.-; HMM-score: 64.1)
    and 17 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone/menaquinone biosynthesis methyltransferase (TIGR01934; EC 2.1.1.-; HMM-score: 28.1)
    Genetic information processing Transcription RNA processing 3' terminal RNA ribose 2'-O-methyltransferase Hen1 (TIGR04074; EC 2.1.1.-; HMM-score: 22.1)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 3' terminal RNA ribose 2'-O-methyltransferase Hen1 (TIGR04074; EC 2.1.1.-; HMM-score: 22.1)
    Genetic information processing Protein fate Protein modification and repair protein-(glutamine-N5) methyltransferase, release factor-specific (TIGR03534; EC 2.1.1.-; HMM-score: 21.1)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides putative sugar O-methyltransferase (TIGR04371; EC 2.1.1.-; HMM-score: 21)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll magnesium protoporphyrin O-methyltransferase (TIGR02021; EC 2.1.1.11; HMM-score: 20.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 3-demethylubiquinone-9 3-O-methyltransferase (TIGR01983; EC 2.1.1.64; HMM-score: 20.7)
    Genetic information processing Protein fate Protein modification and repair methyltransferase, HemK family (TIGR00536; HMM-score: 18.9)
    2-ketoarginine methyltransferase (TIGR04543; EC 2.1.1.243; HMM-score: 16.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Glutathione and analogs putative 4-mercaptohistidine N1-methyltranferase (TIGR04345; HMM-score: 15.3)
    methyltransferase, Rta_06860 family (TIGR04290; EC 2.1.1.-; HMM-score: 15.1)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific (TIGR03533; EC 2.1.1.-; HMM-score: 14.9)
    pseudaminic acid biosynthesis-associated methylase (TIGR03587; HMM-score: 12.9)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific (TIGR03704; EC 2.1.1.-; HMM-score: 12.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit (TIGR02469; EC 2.1.1.132; HMM-score: 12.5)
    Metabolism Amino acid biosynthesis Aspartate family methionine biosynthesis protein MetW (TIGR02081; HMM-score: 11.8)
    Unknown function Enzymes of unknown specificity tRNA (mo5U34)-methyltransferase (TIGR00452; EC 2.1.1.-; HMM-score: 11.6)
  • TheSEED  :
    • Ribosomal RNA large subunit methyltransferase A (EC 2.1.1.51)
  • PFAM:
    NADP_Rossmann (CL0063) Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 48.5)
    Methyltransf_11; Methyltransferase domain (PF08241; HMM-score: 42.4)
    Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 41.4)
    and 15 more
    Methyltransf_12; Methyltransferase domain (PF08242; HMM-score: 25.6)
    MTS; Methyltransferase small domain (PF05175; HMM-score: 24.4)
    Methyltransf_23; Methyltransferase domain (PF13489; HMM-score: 23.5)
    Methyltransf_32; Methyltransferase domain (PF13679; HMM-score: 22.7)
    Methyltransf_8; Hypothetical methyltransferase (PF05148; HMM-score: 18.5)
    Ubie_methyltran; ubiE/COQ5 methyltransferase family (PF01209; HMM-score: 17.8)
    no clan defined DUF4449; Protein of unknown function (DUF4449) (PF14613; HMM-score: 15.4)
    NADP_Rossmann (CL0063) Methyltransf_4; Putative methyltransferase (PF02390; HMM-score: 14.6)
    Methyltransf_18; Methyltransferase domain (PF12847; HMM-score: 14.5)
    DREV; DREV methyltransferase (PF05219; HMM-score: 13.8)
    Fz (CL0644) NPC1_N; Niemann-Pick C1 N terminus (PF16414; HMM-score: 13.8)
    no clan defined DUF1694; Protein of unknown function (DUF1694) (PF07997; HMM-score: 13.6)
    GlnB-like (CL0089) Nit_Regul_Hom; Uncharacterized protein, homolog of nitrogen regulatory protein PII (PF10126; HMM-score: 12.9)
    AB_hydrolase (CL0028) DLH; Dienelactone hydrolase family (PF01738; HMM-score: 12.4)
    NADP_Rossmann (CL0063) NodS; Nodulation protein S (NodS) (PF05401; HMM-score: 11.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9755
    • Cytoplasmic Membrane Score: 0.0076
    • Cell wall & surface Score: 0.0029
    • Extracellular Score: 0.014
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.097922
    • TAT(Tat/SPI): 0.010403
    • LIPO(Sec/SPII): 0.119009
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CBW33506 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNTNLKPKLQRFASATAFACPICQENLTLLETNFKCCNRHSFDLAKFGYVNLAPQIKQSANYDKENFQNRQQILEAGFYQAILDAVSDLLASSKTTTTILDIGCGEGFYSRKLQESHSEKTFYAFDISKDSVQIAAKSEPNWAVNWFVGDLARLPIKDANMDILLDIFSPANYGEFRRVLSKDGILIKVIPTENHLKEIRQRVQDQLTNKEYSNQDIKEHFQEHFTILSSQTASLTKTITAEQLQALLSMTPLLFHVDQSKIDWSKLTEITIEAEILVGKAF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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