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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 05-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae OXC141
  • locus tag: SPNOXC_RS01395 [old locus tags: SPNOXC02530 SPNOXC_02530 ]
  • pan locus tag?: PNEUPAN000981000
  • symbol: SPNOXC_RS01395
  • pan gene symbol?: adk
  • synonym:
  • product: adenylate kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNOXC_RS01395 [old locus tags: SPNOXC02530 SPNOXC_02530 ]
  • symbol: SPNOXC_RS01395
  • product: adenylate kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 239060..239698
  • length: 639
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_017592 (239060..239698) NCBI
  • BioCyc: SPNOXC_RS01395 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0214 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGAATCTTTTGATTATGGGCTTACCTGGTGCAGGTAAGGGAACTCAAGCAGCAAAAATC
    GTAGAACAATTCCATGTTGCACATATCTCAACAGGTGATATGTTCCGCGCTGCAATGGCA
    AATCAAACTGAAATGGGTGTTCTTGCTAAGTCATATATTGACAAGGGTGAATTGGTTCCT
    GACGAAGTTACAAATGGAATCGTAAAAGAACGCCTTTCACAAGATGATATTAAAGAAACA
    GGATTCTTATTGGATGGTTACCCACGTACAATTGAACAAGCTCATGCCTTGGACAAAACA
    TTGGCTGAACTTGGCATTGAACTAGAAGGTGTTATCAATATTGAAGTGAACCCTGACAGC
    CTCTTGGAACGTTTGAGTGGCCGTATCATCCACCGCGTAACTGGAGAAACTTTCCACAAG
    GTCTTTAACCCACCAGTTGACTATAAAGAAGAAGATTACTACCAACGTGAAGATGATAAG
    CCTGAGACAGTAAAACGTCGTTTGGATGTTAATATTGCTCAAGGAGAACCAATCATTGCT
    CACTACCGTGCCAAAGGTTTGGTTCATGACATCGAAGGTAATCAAGATATCAATGATGTC
    TTCTCAGATATTGAAAAAGTATTGACAAATTTGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    639

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNOXC_RS01395 [old locus tags: SPNOXC02530 SPNOXC_02530 ]
  • symbol: SPNOXC_RS01395
  • description: adenylate kinase
  • length: 212
  • theoretical pI: 4.72498
  • theoretical MW: 23706.7
  • GRAVY: -0.389151

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 2.7.4.3?  ExPASy
    Adenylate kinase ATP + AMP = 2 ADP
  • ⊞TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions adenylate kinase (TIGR01351; EC 2.7.4.-; HMM-score: 242.1)
    and 7 more
    UMP-CMP kinase family (TIGR01359; EC 2.7.4.-; HMM-score: 132.8)
    adenylate kinase (TIGR01360; EC 2.7.4.3; HMM-score: 117.9)
    putative cytidylate kinase (TIGR02173; EC 2.7.4.14; HMM-score: 25.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle-docking protein FtsY (TIGR00064; HMM-score: 17)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions cytidylate kinase (TIGR00017; EC 2.7.4.14; HMM-score: 15.7)
    carbohydrate kinase, thermoresistant glucokinase family (TIGR01313; EC 2.7.1.-; HMM-score: 14.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal recognition particle protein (TIGR00959; HMM-score: 12)
  • TheSEED: see SPNOXC02530
  • ⊞PFAM:
    P-loop_NTPase (CL0023) ADK; Adenylate kinase (PF00406; HMM-score: 188.2)
    and 7 more
    AAA_17; AAA domain (PF13207; HMM-score: 91)
    AAA_18; AAA domain (PF13238; HMM-score: 24.7)
    AAA_33; AAA domain (PF13671; HMM-score: 21.2)
    SRP54; SRP54-type protein, GTPase domain (PF00448; HMM-score: 18.6)
    no clan defined ADK_lid; Adenylate kinase, active site lid (PF05191; HMM-score: 13.8)
    P-loop_NTPase (CL0023) Cytidylate_kin; Cytidylate kinase (PF02224; HMM-score: 13.3)
    Thymidylate_kin; Thymidylate kinase (PF02223; HMM-score: 13.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.034194
    • TAT(Tat/SPI): 0.002651
    • LIPO(Sec/SPII): 0.002835
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001050436 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTEMGVLAKSYIDKGELVPDEVTNGIVKERLSQDDIKETGFLLDGYPRTIEQAHALDKTLAELGIELEGVINIEVNPDSLLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDKPETVKRRLDVNIAQGEPIIAHYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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