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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 20-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae OXC141
  • locus tag: SPNOXC_RS04535 [old locus tags: SPNOXC08370 SPNOXC_08370 ]
  • pan locus tag?: PNEUPAN001938000
  • symbol: SPNOXC_RS04535
  • pan gene symbol?: proA
  • synonym:
  • product: glutamate-5-semialdehyde dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNOXC_RS04535 [old locus tags: SPNOXC08370 SPNOXC_08370 ]
  • symbol: SPNOXC_RS04535
  • product: glutamate-5-semialdehyde dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 851961..853223
  • length: 1263
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017592 (851961..853223) NCBI
  • BioCyc: SPNOXC_RS04535 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0823 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGGTGAGTAGACAAGAACAATTTGAACAGGTACAGGCTGTTAAAAAATCGATTAACACA
    GCTAGTGAAGAAGTGAAAAACCAAGTCTTGCTAGCCATGGCTGATCACTTAGTGGCTGCT
    ACTGAGGAAATTTTAGCGGCTAATGCCCTCGATATGGCAGCGGCTAAGGGGAAAATCTCA
    GATGTGATGTTGGATCGTCTTTATTTGGATGCAGATCGTATAGAAGCGATGGCAAGAGGA
    ATTCGTGAAGTGGTTGCCTTACCAGATCCAATCGGTGAAGTTTTAGAAACAAGTCAGCTT
    GAAAATGGTTTGGTTATCACAAAAAAACGTGTAGCTATGGGGGTCATCGGTATTATCTAT
    GAAAGCCGTCCAAATGTGACGTCTGATGCGGCTGCTTTGACTCTTAAGAGTGGAAATGCG
    GTTGTTCTTCGTAGTGGTAAGGATGCCTATCAAACAACCCATGCCATTGTCACAGCCTTG
    AAGAAGGGCTTGGAGACGACTACTATTCATCCAAATGTGATTCAACTGGTGGAGGATACT
    AGCCGTGAAAGTAGTTATGCTATGATGAAGGCCAAGGGCTATCTAGACCTTCTCATTCCT
    CGTGGAGGAGCTGGCTTGATTAATGCAGTAGTTGAGAATGCCATTGTGCCTGTTATCGAG
    ACAGGAACTGGGATTGTCCATGTTTATGTCGATAAGGACGCAGATGACGACAAGGCACTG
    TCTATCATCAACAATGCCAAAACCAGTCGTCCTTCTGTCTGCAATGCCATGGAGGTTCTG
    CTGGTTCATGAAGACAAGGCAGCAAGCTTCCTTCCTCGCTTGGAGCAAGTGCTGGTTGCA
    GATCGAAAAGAAGCTGGGTTGGAACCAATTCAATTCCGCCTAGATAGCAAAGCAAGCCAG
    TTTGTTTCAGGTCAAGCTGCTCAAGCACAAGACTTTGATACCGAGTTTTTAGACTATATT
    CTAGCTGTTAAGGTTGTGAGCAGTTTAGAAGAAGCGGTTGCGCATATTGAATCCCACAGT
    ACCCATCATTCGGATGCTATTGTGACGGAAAATGCTGAAGCTGCAGCATACTTTACAGAT
    CAAGTGGACTCTGCAGCGGTGTATGTTAATGCCTCAACTCGTTTCACAGATGGAGGACAA
    TTTGGTCTTGGTTGTGAAATGGGGATTTCTACTCAGAAATTGCACGCGCGTGGTCCAATG
    GGCTTGAAAGAGTTGACCAGCTACAAGTATGTGGTTGCTGGTGATGGGCAGATAAGGGAG
    TAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1263

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNOXC_RS04535 [old locus tags: SPNOXC08370 SPNOXC_08370 ]
  • symbol: SPNOXC_RS04535
  • description: glutamate-5-semialdehyde dehydrogenase
  • length: 420
  • theoretical pI: 4.8023
  • theoretical MW: 45225.1
  • GRAVY: -0.0257143

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 1.2.1.41?  ExPASy
    Glutamate-5-semialdehyde dehydrogenase L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH
  • ⊞TIGRFAM:
    Metabolism Amino acid biosynthesis Glutamate family glutamate-5-semialdehyde dehydrogenase (TIGR00407; EC 1.2.1.41; HMM-score: 466)
    and 4 more
    Metabolism Amino acid biosynthesis Glutamate family delta l-pyrroline-5-carboxylate synthetase (TIGR01092; HMM-score: 308.5)
    acetaldehyde dehydrogenase (acetylating) (TIGR02518; EC 1.2.1.10; HMM-score: 29.9)
    FAD-linked oxidoreductase (TIGR01679; HMM-score: 14.1)
    Metabolism Energy metabolism Amino acids and amines methylmalonate-semialdehyde dehydrogenase (acylating) (TIGR01722; EC 1.2.1.27; HMM-score: 13.9)
  • TheSEED: see SPNOXC08370
  • ⊞PFAM:
    ALDH-like (CL0099) Aldedh; Aldehyde dehydrogenase family (PF00171; HMM-score: 53.5)
    and 1 more
    PreATP-grasp (CL0483) Rimk_N; RimK PreATP-grasp domain (PF18030; HMM-score: 13.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005126
    • TAT(Tat/SPI): 0.002743
    • LIPO(Sec/SPII): 0.000559
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000254695 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MVSRQEQFEQVQAVKKSINTASEEVKNQVLLAMADHLVAATEEILAANALDMAAAKGKISDVMLDRLYLDADRIEAMARGIREVVALPDPIGEVLETSQLENGLVITKKRVAMGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTALKKGLETTTIHPNVIQLVEDTSRESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPVIETGTGIVHVYVDKDADDDKALSIINNAKTSRPSVCNAMEVLLVHEDKAASFLPRLEQVLVADRKEAGLEPIQFRLDSKASQFVSGQAAQAQDFDTEFLDYILAVKVVSSLEEAVAHIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQKLHARGPMGLKELTSYKYVVAGDGQIRE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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