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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 20-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae OXC141
  • locus tag: SPNOXC_RS05840 [old locus tags: SPNOXC10820 SPNOXC_10820 ]
  • pan locus tag?: PNEUPAN002471000
  • symbol: SPNOXC_RS05840
  • pan gene symbol?: xseA
  • synonym:
  • product: exodeoxyribonuclease VII large subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNOXC_RS05840 [old locus tags: SPNOXC10820 SPNOXC_10820 ]
  • symbol: SPNOXC_RS05840
  • product: exodeoxyribonuclease VII large subunit
  • replicon: chromosome
  • strand: -
  • coordinates: 1106122..1107462
  • length: 1341
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017592 (1106122..1107462) NCBI
  • BioCyc: SPNOXC_RS05840 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1067 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGGAAAAGTATTTATCGGTAACAACTTTGACCAAGTATCTGAAAATGAAATTCGATAAA
    GACCCATACTTGGAACGGGTCTATTTAACTGGTCAAGTTTCCAACTTTCGTAAACGACCT
    ACTCACCAATATTTCTCCCTAAAGGATGACCATGCAGTTATTCAAGCGACCATCTGGTCT
    AGGATTTATCAGAAATTAGGGTTTGACCTGGAAGAAGGAATGAAGATCAATGTGATTGGG
    CGTGTACAGGTCTATGAACCAAGTGGTAGCTACTCCATCATCATTGAAAAAGCTGAGCCT
    GATGGGGTTGGGGCGCTTGCGATTCAGTTTGAACAACTTAAGAAAAAATTGACAGAAGAA
    GGCCTGTTTCAAGAACGCTTCAAGCAAGCTCTGCCCCAATTTTCTAAGAGAATTGGTGTA
    GTAACCAGCCGTAGTGGAGCCGTTATTCGAGATATTATCACGACCGTCAGCAGGCGATTC
    CCAGGTGTTGACATCCTTCTTTATCCGACCAAGGTTCAAGGTGAAGGGGCTGCGGAGGAA
    ATTGCTAGAAATATTGCGCGTGCTAATCAACGGGACGATTTGGATTTGCTCATTATTGGT
    CGTGGAGGTGGTTCTATTGAGGATCTCTGGGCCTTTAACGAAGAAATTGTGGTACGAGCT
    ATTTTTGAATCTCGTTTGCCAGTTATCTCTAGTGTGGGGCATGAGACGGATGTGACCTTG
    GCAGATTTTGTGGCAGATCGACGCGCTGCAACGCCAACAGCGGCGGCTGAACTGGCAACA
    CCTGTGACCAAGTTGGATGTATTAGCTCATTTGCAAAATCAGGAAAAACGGATGGTAACG
    GCAGTCCGAAATGTTCTATCTAAGAAACAAGAGGCTTTGAAAAAATGCAGTCAGTCTGTT
    ATCTTTAGACAACCTGAGCGCTTGTATGACGGTTATTTGCAACGCTTGGACCAACTGCAA
    CTGCGTTTGAAACAAAGTTTGCGAACTCGGATTTCTGATAACAAACAATTAGTTCAAGCA
    AGAACTCATCAATTAGTACAATTATCACCTGTTACCAAAATCCAACGCTATCAAGACCGT
    TTAGGACAGTTGGACAAGCTCTTAGGTAGCCAAATGGCGTTAGTTTATGACGCCAAGGTT
    GCTGAGGCCAAGCGACTTTCGGAAGCTTTGCTCATGTTGGATACTAGCCGAATCGTGGCG
    CGTGGTTATGCTATTGTCAAAAAAGAAGAGTCCGTTGTAGATTCGGTTGAGAGTTTGAAG
    AAAAAAGACCAAGTAACGCTTTTGATGCGAGATGGTCAAGTAGAATTAGAGGTTAAAGAT
    GTCAAAACAAAAGAAATTTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1341

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNOXC_RS05840 [old locus tags: SPNOXC10820 SPNOXC_10820 ]
  • symbol: SPNOXC_RS05840
  • description: exodeoxyribonuclease VII large subunit
  • length: 446
  • theoretical pI: 9.93383
  • theoretical MW: 50607.1
  • GRAVY: -0.314126

⊟Function[edit | edit source]

  • reaction:
    EC 3.1.11.6?  ExPASy
    Exodeoxyribonuclease VII Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates
  • TIGRFAM:
    Genetic information processing DNA metabolism Degradation of DNA exodeoxyribonuclease VII, large subunit (TIGR00237; EC 3.1.11.6; HMM-score: 475.5)
    and 1 more
    Genetic information processing Transcription Transcription factors RNA polymerase sigma factor RpoD (TIGR02393; HMM-score: 22.2)
  • TheSEED: see SPNOXC10820
  • PFAM:
    no clan defined Exonuc_VII_L; Exonuclease VII, large subunit (PF02601; HMM-score: 314.8)
    and 3 more
    OB (CL0021) tRNA_anti_2; OB-fold nucleic acid binding domain (PF13742; HMM-score: 85.3)
    tRNA_anti-codon; OB-fold nucleic acid binding domain (PF01336; HMM-score: 39.4)
    HROB; Homologous recombination OB-fold protein (PF15072; HMM-score: 15.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002411
    • TAT(Tat/SPI): 0.000077
    • LIPO(Sec/SPII): 0.000408
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000417492 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQYFSLKDDHAVIQATIWSRIYQKLGFDLEEGMKINVIGRVQVYEPSGSYSIIIEKAEPDGVGALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRFPGVDILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVVRAIFESRLPVISSVGHETDVTLADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEKRMVTAVRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDNKQLVQARTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEAKRLSEALLMLDTSRIVARGYAIVKKEESVVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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