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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 20-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae OXC141
  • locus tag: SPNOXC_RS09630 [old locus tags: SPNOXC17590 SPNOXC_17590 ]
  • pan locus tag?: PNEUPAN003544000
  • symbol: ccpA
  • pan gene symbol?: ccpA
  • synonym:
  • product: catabolite control protein A

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNOXC_RS09630 [old locus tags: SPNOXC17590 SPNOXC_17590 ]
  • symbol: ccpA
  • product: catabolite control protein A
  • replicon: chromosome
  • strand: -
  • coordinates: 1783675..1784685
  • length: 1011
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_017592 (1783675..1784685) NCBI
  • BioCyc: SPNOXC_RS09630 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1797 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGAATGCAGATGATACAGTAACCATTTATGATGTCGCTCGTGAAGCAGGTGTTTCCATG
    GCGACGGTCAGCCGTGTGGTCAATGGCAATAAAAATGTAAAAGAGAATACCCGTAAAAAA
    GTGCTAGAGGTAATTGATCGTTTGGATTATCGTCCAAATGCAGTTGCGCGTGGTCTTGCA
    AGTAAAAAGACAACCACTGTCGGTGTCGTGATTCCAAATATTACCAATGGTTATTTTTCG
    AGTTTGGCTAAGGGGATTGATGATATTGCAGAAATGTACAAGTACAATATTGTCCTAGCT
    AATAGCGATGAAGATAACGAGAAAGAAGTTTCTGTTGTCAATACCCTCTTTTCAAAGCAG
    GTAGATGGCATTATCTATATGGGTTATCACTTGACAGATAAAATTCGCTCAGAATTTTCG
    CGCTCACGTACTCCGATTGTTCTCGCAGGAACTGTCGATGTTGAGCACCAGTTGCCAAGT
    GTCAATATTGACTATAAGCAAGCAACAATTGATGCAGTGAGTTACCTTGCTAAAGAAAAT
    GAGCGTATTGCTTTCGTTAGCGGTCCGCTAGTGGATGACATCAATGGTAAGGTTCGTTTA
    GTTGGCTACAAGGAAACCTTGAAAAAAGCAGGAATCACTTATAGTGAGGGTTTGGTATTT
    GAATCTAAATATAGCTATGATGATGGTTACGACTTAGCAGAGCGTTTGATTTCATCAAAT
    GCAACTGCAGCAGTTGTGACAGGTGATGAGTTGGCAGCAGGAGTCTTGAACGGTTTGGCT
    GATAAAGGTGTTTCTGTGCCAGAAGATTTTGAAATTATTACTAGTGATGATTCACAAATC
    TCACGCTTTACCCGTCCAAACTTGACAACGATTGCCCAACCTCTTTATGACCTTGGTGCT
    ATTAGTATGCGTATGTTGACCAAGATTATGCATAAGGAAGAGTTGGAAGAACGTGAAGTT
    CTCTTACCTCATGGTTTGACAGAACGTAGCTCAACACGAAAACGTAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1011

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNOXC_RS09630 [old locus tags: SPNOXC17590 SPNOXC_17590 ]
  • symbol: CcpA
  • description: catabolite control protein A
  • length: 336
  • theoretical pI: 5.17046
  • theoretical MW: 37116.8
  • GRAVY: -0.277083

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions catabolite control protein A (TIGR01481; HMM-score: 576.8)
    and 8 more
    Signal transduction Regulatory functions DNA interactions D-fructose-responsive transcription factor (TIGR02417; HMM-score: 141.6)
    Signal transduction Regulatory functions DNA interactions trehalose operon repressor (TIGR02405; HMM-score: 93.8)
    rhamnose ABC transporter, rhamnose-binding protein (TIGR02637; HMM-score: 18.1)
    Genetic information processing Mobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 14.2)
    Signal transduction Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 14.2)
    Signal transduction Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 14.2)
    Genetic information processing Mobile and extrachromosomal element functions Prophage functions phage-associated protein, BcepMu gp16 family (TIGR04111; HMM-score: 14)
    Signal transduction Regulatory functions DNA interactions transcriptional repressor BetI (TIGR03384; HMM-score: 12.2)
  • TheSEED: see SPNOXC17590
  • PFAM:
    Periplas_BP (CL0144) Peripla_BP_3; Periplasmic binding protein-like domain (PF13377; HMM-score: 92.2)
    Peripla_BP_1; Periplasmic binding proteins and sugar binding domain of LacI family (PF00532; HMM-score: 79.8)
    HTH (CL0123) LacI; Bacterial regulatory proteins, lacI family (PF00356; HMM-score: 73.8)
    and 7 more
    Periplas_BP (CL0144) Peripla_BP_4; Periplasmic binding protein domain (PF13407; HMM-score: 60.8)
    HTH (CL0123) HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 16.6)
    HTH_3; Helix-turn-helix (PF01381; HMM-score: 16.4)
    HTH_31; Helix-turn-helix domain (PF13560; HMM-score: 14.1)
    no clan defined DUF5886; Family of unknown function (DUF5886) (PF19233; HMM-score: 13.9)
    HTH (CL0123) Trp_repressor; Trp repressor protein (PF01371; HMM-score: 12.7)
    no clan defined DUF6148; Family of unknown function (DUF6148) (PF19645; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by CcpA, TF important in Global catabolite repression: in TIGR4

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.012656
    • TAT(Tat/SPI): 0.002715
    • LIPO(Sec/SPII): 0.003638
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000990608 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNADDTVTIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEVIDRLDYRPNAVARGLASKKTTTVGVVIPNITNGYFSSLAKGIDDIAEMYKYNIVLANSDEDNEKEVSVVNTLFSKQVDGIIYMGYHLTDKIRSEFSRSRTPIVLAGTVDVEHQLPSVNIDYKQATIDAVSYLAKENERIAFVSGPLVDDINGKVRLVGYKETLKKAGITYSEGLVFESKYSYDDGYDLAERLISSNATAAVVTGDELAAGVLNGLADKGVSVPEDFEIITSDDSQISRFTRPNLTTIAQPLYDLGAISMRMLTKIMHKEELEEREVLLPHGLTERSSTRKRK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Ramkumar Iyer, Nitin S Baliga, Andrew Camilli
Catabolite control protein A (CcpA) contributes to virulence and regulation of sugar metabolism in Streptococcus pneumoniae.
J Bacteriol: 2005, 187(24);8340-9
[PubMed:16321938] [WorldCat.org] [DOI] (P p)Greer E Kaufman, Janet Yother
CcpA-dependent and -independent control of beta-galactosidase expression in Streptococcus pneumoniae occurs via regulation of an upstream phosphotransferase system-encoding operon.
J Bacteriol: 2007, 189(14);5183-92
[PubMed:17496092] [WorldCat.org] [DOI] (P p)

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