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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-OCT-2019

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae NU83127
  • locus tag: SPNU_0445 [new locus tag: EL277_RS02380 ]
  • pan locus tag?: PNEUPAN001317000
  • symbol: SPNU_0445
  • pan gene symbol?: rrgA
  • synonym:
  • product: hypothetical protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNU_0445 [new locus tag: EL277_RS02380 ]
  • symbol: SPNU_0445
  • product: hypothetical protein
  • replicon: chromosome
  • strand: +
  • coordinates: 445644..448304
  • length: 2661
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: AP018936 (445644..448304) NCBI
  • BioCyc: see EL277_RS02380
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    ATGAAAAAAGTAAGAAAGATATTTCAGAAGGCAGTTGCAGGACTGTGCTGTATATCTCAG
    TTGACAGCTTTTTCTTCGATAGTTGCTTTAGCAGAAACGCCTGAAACCAGTCCAGCGATA
    GGAAAAGTAGTGATTAAGGAGACAGGCGAAGGAGGAGCGCTTCTAGGAGATGCCGTCTTT
    GAGTTGAAAAACAATACGGATGGCACAACTGTTTCGCAAAGGACAGAGGCGCAAACAGGA
    GAAGCGATATTTTCAAACATAAAACCTGGGACATACACCTTGACAGAAGCCCAACCTCCA
    GTTGGTTATAAACCCTCTACTAAACAATGGACTGTTGAAGTTGAGAAGAATGGTCGGACG
    ACTGTCCAAGGTGAACAGGTAGAAAATCGAGAAGAGGCTCTATCTGACCAGTATCCACAA
    ACAGGGACTTATCCAGATGTTCAAACACCTTATCAGATTATTAAGGTAGATGGTTCGGAA
    AAAAACGGACAGCACAAGGCGTTGAATCCGAATCCATATGAACGTGTGATTCCAGAAGGT
    ACACTTTCAAAGAGAATTTATCAAGTGAATAATTTGGATGATAACCAATATGGAATCGAA
    TTGACGGTTAGTGGGAAAACAGTGTATGAACAAAAAGATAAGTCTGTGCCGCTGGATGTC
    GTTATCTTGCTCGATAACTCAAATAGTATGAGTAACATTCGAAACAAGAATGCTCGACGT
    GCGGAAAGAGCTGGTGAGGCGACACGTTCTCTTATTGATAAAATTACATCTGATTCAGAA
    AATAGGGTAGCGCTTGTGACTTATGCTTCCACTATCTTTGATGGGACCGAGTTTACAGTA
    GAAAAAGGGGTAGCAGATAAAAACGGAAAGCGATTGAATGATTCTCTTTTTTGGAATTAT
    GATCAGACGAGTTTTACAACCAATACCAAAGATTATAGTTATTTAAAGCTGACTAATGAT
    AAGAATGACATTGTAGAATTAAAAAATAAGGTACCTACCGAGGCAGAAGACCATGATGGA
    AATAGATTGATGTACCAATTCGGTGCCACTTTTACTCAGAAAGCTTTGATGAAGGCAGAT
    GAGATTTTGACACAACAAGCGAGACAAAATAGTCAAAAAGTCATTTTCCATATTACGGAT
    GGTGTCCCAACTATGTCGTATCCGATTAATTTTAATCATGCTACGTTTGCTCCATCATAT
    CAAAATCAACTAAATGCATTTTTTAGTAAATCTCCTAATAAAGATGGAATACTATTAAGT
    GATTTTATTACGCAAGCAACTAGTGGAGAACATACAATTGTACGCGGAGATGGGCAAAGT
    TACCAGATGTTTACAGATAAGACAGTTTATGAAAAAGGTGCTCCTGCAGCTTTCCCAGTT
    AAACCTGAAAAATATTCTGAAATGAAGGCGGCTGGTTATGCAGTTATAGGCGATCCAATT
    AATGGTGGATATATTTGGCTTAATTGGAGAGAGAGTATTCTGGCTTATCCGTTTAATTCT
    AATACTGCTAAAATTACCAATCATGGTGACCCTACAAGATGGTATTATAACGGGAATATT
    GCTCCTGATGGGTATGATGTCTTTACGGTAGGTATTGGTATTAACGGAGATCCTGGTACG
    GATGAAGCAACGGCTACTAGTTTTATGCAAAGTATTTCTAGTAAACCTGAAAACTATACC
    AATGTTACTGACACGACAAAAATATTGGAACAGTTGAATCGTTATTTCCACACCATCGTA
    ACTGAAAAGAAATCAATTGAGAATGGTACGATTACAGATCCGATGGGTGAGTTAATTGAT
    TTGCAATTGGGCACAGATGGAAGATTTGATCCAGCAGATTACACTTTAACTGCAAACGAT
    GGTAGTCGCTTGGAGAATGGACAAGCTGTAGGTGGTCCACAAAATGATGGTGGTTTGTTA
    AAAAATGCAAAAGTGCTCTATGATACGACTGAGAAAAGGATTCGTGTAACAGGTCTGTAC
    CTTGGAACGGATGAAAAAGTTACGTTGACCTACAATGTTCGTTTGAATGATGAGTTTGTA
    AGCAATAAATTTTATGATACCAATGGTCGAACAACCTTACATCCTAAGGAAGTAGAACAG
    AACACAGTGCGCGACTTCCCGATTCCTAAGATTCGTGATGTGCGGAAGTATCCAGAAATC
    ACAATTTCAAAAGAGAAAAAACTTGGTGACATTGAGTTTATTAAGGTCAATAAAAATGAT
    AAAAAACCACTGAGAGGTGCGGTCTTTAGTCTTCAAAAACAACATCCGGATTATCCAGAT
    ATTTATGGAGCTATTGATCAAAATGGCACTTATCAAAATGTGAGAACAGGTGAAGATGGT
    AAGTTGACCTTTAAAAATCTGTCAGATGGGAAATATCGATTATTTGAAAATTCTGAACCA
    GCTGGTTATAAACCCGTTCAAAATAAGCCTATCGTTGCCTTCCAAATAGTAAATGGAGAA
    GTCAGAGATGTGACTTCAATCGTTCCACAAGATATACCAGCGGGTTACGAGTTTACGAAT
    GATAAGCACTATATTACCAATGAACCTATTCCTCCAAAGAGAGAATATCCTCGAACTGGT
    GGTATCGGAATGTTGCCATTCTATCTGATAGGTTGCATGATGATGGGAGGAGTTCTATTA
    TACACACGGAAACATCCGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2661

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNU_0445 [new locus tag: EL277_RS02380 ]
  • symbol: SPNU_0445
  • description: hypothetical protein
  • length: 886
  • theoretical pI: 5.92811
  • theoretical MW: 98848
  • GRAVY: -0.627652

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 14.5)
  • TheSEED: data available for Hungary19A-6, TIGR4
  • PFAM:
    Transthyretin (CL0287) SpaA; Prealbumin-like fold domain (PF17802; HMM-score: 96.7)
    and 10 more
    vWA-like (CL0128) VWA_2; von Willebrand factor type A domain (PF13519; HMM-score: 45)
    VWA; von Willebrand factor type A domain (PF00092; HMM-score: 44.5)
    Transthyretin (CL0287) SdrD_B; SdrD B-like domain (PF17210; HMM-score: 31.4)
    CarboxypepD_reg; Carboxypeptidase regulatory-like domain (PF13620; HMM-score: 29.7)
    SpaA_2; Prealbumin-like fold domain (PF19403; HMM-score: 23)
    E-set (CL0159) Y_Y_Y; Y_Y_Y domain (PF07495; HMM-score: 18.9)
    Transthyretin (CL0287) EMC7_beta-sandw; ER membrane protein complex subunit 7, beta-sandwich domain (PF09430; HMM-score: 18.1)
    fn3_3; Polysaccharide lyase family 4, domain II (PF14686; HMM-score: 16.1)
    Met_repress (CL0057) RelB; RelB antitoxin (PF04221; HMM-score: 12.8)
    Transthyretin (CL0287) CarbopepD_reg_2; CarboxypepD_reg-like domain (PF13715; HMM-score: 11.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helix: 1
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0005
    • Cytoplasmic Membrane Score: 0.1268
    • Cell wall & surface Score: 0.6786
    • Extracellular Score: 0.194
  • SignalP: Signal peptide SP(Sec/SPI) length 31 aa
    • SP(Sec/SPI): 0.992954
    • TAT(Tat/SPI): 0.002641
    • LIPO(Sec/SPII): 0.003219
    • Cleavage Site: CS pos: 31-32. ALA-ET. Pr: 0.9471
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBG34336 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKKVRKIFQKAVAGLCCISQLTAFSSIVALAETPETSPAIGKVVIKETGEGGALLGDAVFELKNNTDGTTVSQRTEAQTGEAIFSNIKPGTYTLTEAQPPVGYKPSTKQWTVEVEKNGRTTVQGEQVENREEALSDQYPQTGTYPDVQTPYQIIKVDGSEKNGQHKALNPNPYERVIPEGTLSKRIYQVNNLDDNQYGIELTVSGKTVYEQKDKSVPLDVVILLDNSNSMSNIRNKNARRAERAGEATRSLIDKITSDSENRVALVTYASTIFDGTEFTVEKGVADKNGKRLNDSLFWNYDQTSFTTNTKDYSYLKLTNDKNDIVELKNKVPTEAEDHDGNRLMYQFGATFTQKALMKADEILTQQARQNSQKVIFHITDGVPTMSYPINFNHATFAPSYQNQLNAFFSKSPNKDGILLSDFITQATSGEHTIVRGDGQSYQMFTDKTVYEKGAPAAFPVKPEKYSEMKAAGYAVIGDPINGGYIWLNWRESILAYPFNSNTAKITNHGDPTRWYYNGNIAPDGYDVFTVGIGINGDPGTDEATATSFMQSISSKPENYTNVTDTTKILEQLNRYFHTIVTEKKSIENGTITDPMGELIDLQLGTDGRFDPADYTLTANDGSRLENGQAVGGPQNDGGLLKNAKVLYDTTEKRIRVTGLYLGTDEKVTLTYNVRLNDEFVSNKFYDTNGRTTLHPKEVEQNTVRDFPIPKIRDVRKYPEITISKEKKLGDIEFIKVNKNDKKPLRGAVFSLQKQHPDYPDIYGAIDQNGTYQNVRTGEDGKLTFKNLSDGKYRLFENSEPAGYKPVQNKPIVAFQIVNGEVRDVTSIVPQDIPAGYEFTNDKHYITNEPIPPKREYPRTGGIGMLPFYLIGCMMMGGVLLYTRKHP

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Julianna LeMieux, David L Hava, Alan Basset, Andrew Camilli
RrgA and RrgB are components of a multisubunit pilus encoded by the Streptococcus pneumoniae rlrA pathogenicity islet.
Infect Immun: 2006, 74(4);2453-6
[PubMed:16552078] [WorldCat.org] [DOI] (P p)

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