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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 25-OCT-2019

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae HU-OH
  • locus tag: SPOH_1385 [new locus tag: EL271_RS07470 ]
  • pan locus tag?: PNEUPAN002850000
  • symbol: patB
  • pan gene symbol?: patB2
  • synonym:
  • product: Cystathionine beta-lyase PatB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPOH_1385 [new locus tag: EL271_RS07470 ]
  • symbol: patB
  • product: Cystathionine beta-lyase PatB
  • replicon: chromosome
  • strand: -
  • coordinates: 1386558..1387724
  • length: 1167
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGGGAAAATATGATTTTACAAGCCTGCCCAACCGTTTAGGGCACCATACCTATAAATGG
    AAAGAAACAGAAACGGATAGTGAAGTTCTACCAGCTTGGATAGCGGATATGGACTTTGTG
    GTCTTGCCTGAAATCCGCCAAGCCGTGCAAACTTACGCAGACCAACTGGTTTATGGTTAT
    ACCTATGCCAGTGAAGACTTAATTAAGGAAGTTCAAAAGTGGGAAGCTACACAATACGGT
    TACAACTTTGACAAAGAGGCTCTTGTCTTTATCGAGGGTGTGGTACCAGCCATCTCAACA
    GCTATTCAAACCTTTACAAAAGAAGGCGAGGCGGTTTTAATTAACACGCCTGTCTACCCA
    CCCTTTGCTCGCAGTGTCAAGTTGAATAATCGTAGATTGATTACTAATTCCTTAGTGGAA
    AAGGATGGTCTGTTTGAGATTGACTTTGACCAACTTGAAAAGGATTTGGTGGAAGAGGAG
    GTTAAACTCTATATTCTTTGCAACCCTCACAATCCTGGTGGACGTGTTTGGGAAAAAGAA
    GTGTTGGAGAAGATTGGCCAACTCTGCCAAAAACACGGTGTTTTGTTAGTTTCGGATGAG
    ATTCACCAAGATTTGACCCTCTTTGGTCACAAACACCAGTCTTTCAATACCATCAATCCT
    GCCTTCAAAAATTTTGCTATCGTCTTGAGCAGTGCCACTAAAACATTTAATATTGCTGGA
    ACAAAAAATTCCTATGCAGTCATTGAAAATCCTAAGTTGAGACTAGCTTTCCAGAAACGC
    CTGTTGGCCAATAATCAGCATGAAATTTCAGGCTTGGGTTATTTGGCGACAGAAGCTGCC
    TATAGATACGGTAAAGATTGGCTAGAGGAACTCAAGCAAGTCTTTCAAGACCACATCAAT
    TATGTGGTGGATCTATTTGGAAAAGAGACTAAAATCAAGGTCATGAAACCGCAAGGTACC
    TACTTGATTTGGCTTGACTTTTCAGCCTATGACCTGACTGATGAAACATTGCAAGAGTTG
    TTGAGAAATGAAGCCAAGGTTATCCTCAACCGTGGTTTGGATTTTGGAGAGGAAGGAAGT
    CTCCATTCCCGCATCAATATAGCTATGCCCAAATCTCTGTTGCAAGAAGTCTGTCAGCGG
    ATTGTGGCTACTTTTGCCAAACGTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1167

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPOH_1385 [new locus tag: EL271_RS07470 ]
  • symbol: PatB
  • description: Cystathionine beta-lyase PatB
  • length: 388
  • theoretical pI: 5.65353
  • theoretical MW: 44478.4
  • GRAVY: -0.287629

⊟Function[edit | edit source]

  • TIGRFAM:
    putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 394.3)
    and 19 more
    LL-diaminopimelate aminotransferase (TIGR03540; EC 2.6.1.83; HMM-score: 105.4)
    tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 102.2)
    Metabolism Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 91.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin threonine-phosphate decarboxylase (TIGR01140; EC 4.1.1.81; HMM-score: 70.9)
    succinyldiaminopimelate transaminase (TIGR03537; EC 2.6.1.17; HMM-score: 67.6)
    Metabolism Amino acid biosynthesis Histidine family histidinol-phosphate transaminase (TIGR01141; EC 2.6.1.9; HMM-score: 62.1)
    LL-diaminopimelate aminotransferase (TIGR03542; EC 2.6.1.83; HMM-score: 52.3)
    beta-methylarginine biosynthesis bifunctional aminotransferase (TIGR04544; EC 2.6.-.-; HMM-score: 51.1)
    succinyldiaminopimelate transaminase (TIGR03538; EC 2.6.1.17; HMM-score: 46.1)
    Cellular processes Cellular processes Biosynthesis of natural products capreomycidine synthase (TIGR03947; HMM-score: 41.7)
    succinyldiaminopimelate transaminase (TIGR03539; EC 2.6.1.17; HMM-score: 38.4)
    enduracididine biosynthesis enzyme MppQ (TIGR04461; EC 2.-.-.-; HMM-score: 34)
    enduracididine biosynthesis enzyme MppP (TIGR04462; EC 2.-.-.-; HMM-score: 23.5)
    Metabolism Energy metabolism Amino acids and amines aspartate 4-decarboxylase (TIGR03801; EC 4.1.1.12; HMM-score: 22.7)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 19.5)
    ornithine--oxo-acid transaminase (TIGR01885; EC 2.6.1.13; HMM-score: 16)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin adenosylmethionine-8-amino-7-oxononanoate transaminase (TIGR00508; EC 2.6.1.62; HMM-score: 14.6)
    Metabolism Central intermediary metabolism Other 4-aminobutyrate transaminase (TIGR00700; EC 2.6.1.19; HMM-score: 13)
    transaminase, acetylornithine/succinylornithine family (TIGR00707; HMM-score: 13)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 155.8)
    and 5 more
    Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 17.7)
    Aminotran_3; Aminotransferase class-III (PF00202; HMM-score: 14.5)
    Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 13.4)
    no clan defined Frankia_peptide; Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. (PF14407; HMM-score: 12.3)
    PLP_aminotran (CL0061) Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 11.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003434
    • TAT(Tat/SPI): 0.000212
    • LIPO(Sec/SPII): 0.000281
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: BBG37410 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MGKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPEIRQAVQTYADQLVYGYTYASEDLIKEVQKWEATQYGYNFDKEALVFIEGVVPAISTAIQTFTKEGEAVLINTPVYPPFARSVKLNNRRLITNSLVEKDGLFEIDFDQLEKDLVEEEVKLYILCNPHNPGGRVWEKEVLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTINPAFKNFAIVLSSATKTFNIAGTKNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLATEAAYRYGKDWLEELKQVFQDHINYVVDLFGKETKIKVMKPQGTYLIWLDFSAYDLTDETLQELLRNEAKVILNRGLDFGEEGSLHSRINIAMPKSLLQEVCQRIVATFAKR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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