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TCH8431/19A
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Xen35
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gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae P1031
  • locus tag: SPP_0027 [new locus tag: SPP_RS00135 ]
  • pan locus tag?: PNEUPAN000382000
  • symbol: purA
  • pan gene symbol?: purA
  • synonym:
  • product: adenylosuccinate synthetase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPP_0027 [new locus tag: SPP_RS00135 ]
  • symbol: purA
  • product: adenylosuccinate synthetase
  • replicon: chromosome
  • strand: +
  • coordinates: 22790..24118
  • length: 1329
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGTATGTGAGAAAGGAAGAGCCTGAGGGCTCAGACAAAATTATGACTTCAGTTGTTGTT
    GTAGGTACCCAATGGGGTGATGAAGGTAAAGGGAAGATTACAGACTTCCTTTCAGCGAAT
    GCAGAAGTGATTGCACGTTACCAAGGTGGTGATAATGCTGGTCACACGATTGTGATTGAC
    GGTAAGAAATTTAAGTTGCACTTGATTCCATCTGGGATTTTCTTCCCTGAAAAAATATCT
    GTCATTGGGAATGGTATGGTTGTAAATCCTAAATCTCTTGTAAAAGAGTTGAGCTATCTT
    CATGAGGAAGGTGTAACAACTGATAACTTACGTATTTCTGATCGTGCGCATGTTATTTTG
    CCTTATCATATCGAGTTGGATCGCTTGCAAGAAGAAGCTAAGGGCGACAATAAGATTGGT
    ACGACAATTAAGGGAATTGGTCCAGCTTATATGGACAAGGCTGCTCGTGTTGGAATTCGT
    ATTGCAGATCTTTTAGATAAAGATATTTTCCGTGAGCGTTTAGAACGTAACCTTGCTGAA
    AAGAATCGTCTTTTTGAAAAATTGTATGACAGTAAAGCGATTGTTTTCGATGATATTTTT
    GAAGAATATTACGAATATGGTCAACAAATCAAGAAATACGTGATAGATACATCTGTTATC
    TTGAATGATGCGCTTGATAATGGCAAACGTGTGCTTTTTGAAGGTGCACAAGGTGTTATG
    CTAGATATCGACCAAGGTACTTATCCATTTGTTACGTCATCAAACCCTGTAGCTGGTGGT
    GTGACAATTGGTTCTGGTGTCGGTCCAAGCAAGATTGACAAGGTTGTAGGTGTATGTAAA
    GCTTATACGAGTCGTGTAGGAGATGGTCCTTTCCCAACTGAGTTGTTTGATGAAGTGGGA
    GAACGTATCCGTGAAGTGGGTCATGAATATGGTACAACAACTGGTCGTCCACGTCGTGTA
    GGTTGGTTTGACTCAGTTGTGATGCGTCATAGCCGTCGTGTTTCTGGTATTACTAACCTT
    TCTTTGAACTCTATTGATGTTTTGAGCGGTTTGGATACTGTGAAAATCTGTGTGGCCTAT
    GATCTTGACGGTCAACGTATTGACTACTATCCAGCTAGTCTTGAGCAATTGAAACGTTGC
    AAGCCTATCTATGAAGAGTTGCCAGGTTGGTCAGAAGATATTACCGGAGTTCGCAATTTG
    GAAGATCTTCCTGAGAATGCGCGTAACTATGTTCGTCGTGTGAGTGAATTGGTTGGCGTT
    CGTATTTCTACTTTCTCAGTAGGTCCTGGTCGTGAACAAACAAATATTTTAGAAAGTGTT
    TGGTCCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1329

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPP_0027 [new locus tag: SPP_RS00135 ]
  • symbol: PurA
  • description: adenylosuccinate synthetase
  • length: 442
  • theoretical pI: 5.2809
  • theoretical MW: 49232.5
  • GRAVY: -0.311086

⊟Function[edit | edit source]

  • reaction:
    EC 6.3.4.4?  ExPASy
    Adenylosuccinate synthase GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis adenylosuccinate synthase (TIGR00184; EC 6.3.4.4; HMM-score: 629.3)
  • TheSEED  :
    • Adenylosuccinate synthetase (EC 6.3.4.4)
    Miscellaneous Miscellaneous - no subcategory EC 6.3.4.- Ligases that form carbon-nitrogen bonds  Adenylosuccinate synthetase (EC 6.3.4.4)
    and 1 more
    Nucleosides and Nucleotides Purines Purine conversions  Adenylosuccinate synthetase (EC 6.3.4.4)
  • PFAM:
    P-loop_NTPase (CL0023) Adenylsucc_synt; Adenylosuccinate synthetase (PF00709; HMM-score: 623.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9885
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0112
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.015393
    • TAT(Tat/SPI): 0.001144
    • LIPO(Sec/SPII): 0.006189
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACO21906 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MYVRKEEPEGSDKIMTSVVVVGTQWGDEGKGKITDFLSANAEVIARYQGGDNAGHTIVIDGKKFKLHLIPSGIFFPEKISVIGNGMVVNPKSLVKELSYLHEEGVTTDNLRISDRAHVILPYHIELDRLQEEAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFRERLERNLAEKNRLFEKLYDSKAIVFDDIFEEYYEYGQQIKKYVIDTSVILNDALDNGKRVLFEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPSKIDKVVGVCKAYTSRVGDGPFPTELFDEVGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVLSGLDTVKICVAYDLDGQRIDYYPASLEQLKRCKPIYEELPGWSEDITGVRNLEDLPENARNYVRRVSELVGVRISTFSVGPGREQTNILESVWS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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