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NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae P1031
  • locus tag: SPP_2002 [new locus tag: SPP_RS09865 ]
  • pan locus tag?: PNEUPAN003598000
  • symbol: SPP_2002
  • pan gene symbol?: thiN
  • synonym:
  • product: thiamine pyrophosphokinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPP_2002 [new locus tag: SPP_RS09865 ]
  • symbol: SPP_2002
  • product: thiamine pyrophosphokinase
  • replicon: chromosome
  • strand: -
  • coordinates: 1841234..1841896
  • length: 663
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGAGCGAGTACAAACTCTCAGAAAACAACTGGACTAGGGTTGCCGTTTTTGCAGGCGGA
    GACCGCGGTCATTATCGGACGGACTTTGATGGTTTTGTTGGTGTGGATCGAGGCTCGCTC
    TGGATCTTGGAAGAAGATTTGCCTCTTGCTCTAGCAGTCGGAGATTTTGATTCTGTGACG
    GAAGAAGAGCGACAGGTGATTCAAAAACGTGCCCAGTATTTTGTCCAAGCCCGGCCAGAA
    AAAGATGATACTGATTTGGAATTGGCTCTCTTGACCATCTTTAAGCAAAATCCTCAGGCT
    CAGGTTACTATTTTCGGTGCCTTGGGTGGCCGTATTGACCATATGTTGGCCAATGTCTTT
    CTGCCTAGCAATCCTAAGTTGGCACCCTATATGCATCAAATAGAAATTGAGGATGGGCAA
    AACTTGATTACTTATTGTCCAGAAGGAATCAGTCAGCTAGAACCTCGTTCAGACTACGAC
    TATCTAGCCTTTATGCCAGTTCGGGATAGCCAGCTGACTATTCTTGGAGCCAAGTATGAG
    TTGACAGAGGAAAATTTTTTCTTTAAAAAAGTGTACGCTTCTAACGAATATATAGATAGG
    GAAGTGTCGGTAACTTGCCCAGATGGTTATGTGGTCGTACTGCATAGCAAGGACAGGAGG
    TAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    663

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPP_2002 [new locus tag: SPP_RS09865 ]
  • symbol: SPP_2002
  • description: thiamine pyrophosphokinase
  • length: 220
  • theoretical pI: 4.42595
  • theoretical MW: 25173.1
  • GRAVY: -0.365

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.6.2?  ExPASy
    Thiamine diphosphokinase ATP + thiamine = AMP + thiamine diphosphate
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiamine pyrophosphokinase (TIGR01378; EC 2.7.6.2; HMM-score: 168.1)
  • TheSEED  :
    • Thiamin pyrophosphokinase (EC 2.7.6.2)
    Cofactors, Vitamins, Prosthetic Groups, Pigments Cofactors, Vitamins, Prosthetic Groups, Pigments - no subcategory Thiamin biosynthesis  Thiamin pyrophosphokinase (EC 2.7.6.2)
  • PFAM:
    no clan defined TPK_catalytic; Thiamin pyrophosphokinase, catalytic domain (PF04263; HMM-score: 58.8)
    and 1 more
    TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain (PF04265; HMM-score: 33.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9996
    • Cytoplasmic Membrane Score: 0.0001
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0003
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00249
    • TAT(Tat/SPI): 0.000129
    • LIPO(Sec/SPII): 0.000395
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACO21896 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSEYKLSENNWTRVAVFAGGDRGHYRTDFDGFVGVDRGSLWILEEDLPLALAVGDFDSVTEEERQVIQKRAQYFVQARPEKDDTDLELALLTIFKQNPQAQVTIFGALGGRIDHMLANVFLPSNPKLAPYMHQIEIEDGQNLITYCPEGISQLEPRSDYDYLAFMPVRDSQLTILGAKYELTEENFFFKKVYASNEYIDREVSVTCPDGYVVVLHSKDRR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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